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Biomedical subjects

G Moulin

Publications and source records attributed to G Moulin.

At least 361 records · Page 20Linked to original sources
PubMedDate not supplied

Serum bFGF (basic fibroblast growth factor) and CA 15.3 in the monitoring of breast cancer patients.

BACKGROUND: Basic fibroblast growth factor (bFGF) is a potent angiogenetic factor which may influence breast cancer evolution. MATERIALS AND METHODS: Serum bFGF, (cut-off 10 pg/ml), was assayed in 166 breast cancer patients at all stages and compared with CA 15.3. RESULTS: In 99 pre-treatment (PT) sera, 39/99 (39.4%) were bFGF positive, 9/99 (9.1%) CA 15.3 positive (> 30 U/ml), and not correlated. No correlations were found between bFGF and age, menopausal status, TNM or pTNM, histology, SBR grading or steroid receptors. A postoperative decline in bFGF positivity, from 30.8 to 7.7% (n = 39), was observed. An abnormal CA 15.3 after primary treatment (n = 2/39) was of bad prognosis (P < 0.0001), whereas positive bFGF (n = 3/39) had no univariate prognostic value (median follow-up 5.5 years). During follow-up, positive bFGF was recorded in 6/92 (6.5%) disease-free patients (DFS), 13/15 (86.7%) regressions, 8/16 (50.0%) stable disease, and 46/67 (68.7%) progressive disease (significant differences between PT or DFS and post recurrence levels (P < 0.001), and between relapse before and after treatment (P = 0.002)). CONCLUSION: Serum bFGF is more often elevated before treatment or after relapse than in DFS, and rises under systemic treatments. Its pattern of variations does not add to CA 15.3 for breast cancer monitoring.

Age Factors↗
PubMedDate not supplied

[Radio-anatomy of the paranasal sinuses].

UNLABELLED: The imaging anatomy of the paranasal sinuses presents some complexity. The paranasal sinuses develop within facial and cranial bones. They communicate with one another and with the nasal cavity. Knowledge of normal anatomy is mandatory for accurate diagnosis of sinonasal pathology. The most frequent anatomical variants should be identified to decrease surgical risks. CT is the main imaging modality for the evaluation of sinonasal pathology. LEARNING OBJECTIVES: to review the normal sinonasal anatomy and its frequent anatomical variants at CT imaging.

Facial Bones↗
PubMedDate not supplied

[Radiologic imaging of chronic sinusitis in the adult].

The diagnosis of chronic sinusitis is based on clinical presentation, nasal endoscopy and CT scan. As a matter of fact, the CT scan of the paranasal sinuses is absolutely necessary to characterise the lesions, to visualise anatomic variations which are risk factors for the endoscopic surgery and to follow up treated and/or operated patients with recurrent symptoms. Nowadays, plain films of paranasal sinuses do not have any indication. MR Imaging may be indicated in selected cases of complicated sinusitis and of pseudotumors associated to sinusitis.

Adult↗
PubMedDate not supplied

Comparison of automated liquid chromatographic and bioassay methods for determining spiramycin concentration in bovine plasma.

The performance of a liquid chromatographic (LC) method for spiramycin measurement in bovine plasma has been compared with that of a microbiological method. Plasma samples were obtained from cattle administered spiramycin intravenously. Comparison tests used were intraclass correlation (r1), correlation (r), and Student's paired t-test. For concentrations lower than 2.5 IU/mL, microbiological values were higher than LC values. This difference in results modified pharmacokinetic interpretation and might be explained by the presence of microbiologically active metabolites.

Animals↗
PubMedDate not supplied

[Multicentric clinical trial of a new combination of a broad spectrum antimycotic and a dermocorticoid (author's transl)].

After having reviewed the conditions of use of an antimycotic-corticoid combination, the authors are reporting their clinical results on 183 patients of a new drug combining econazole and triamcinolon. This clinical trial demonstrates that the own activity of each component of the combination is entirely maintained, and that the new combination shows an original interest in the treatment of all inflammatory dermatomycoses, as well as inflammatory supra-infected dermatoses.

Administration, Topical↗
PubMedDate not supplied

[Bucco-pharyngeal and esophageal localizations in Crohn's disease].

A case of upper esophageal stenosis associated with pharyngeal lesions in Crohn's disease is reported. The esophageal stricture was intractable by endoscopic dilatation. This patient was managed successfully by total esophagectomy. The left colon was used to replace the esophagus through a posterior mediastinal route. Histologically, the lesions were epithelioid granulomas with ulcerative fissurations and submucosal lymphoid nodules and were suggestive of Crohn's disease involving the upper esophagus and pharynx only. Similar cases involving only the upper digestive tract with pathologic proof have not yet been reported in the literature.

Crohn Disease↗
PubMedDate not supplied

[Lichen striatus].

Explore the source record for details and available documents.

Adult↗