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Biomedical subjects

G Moser

Publications and source records attributed to G Moser.

At least 19 recordsLinked to original sources
PubMed1992

A five year (1985-1989) retrospective study of equine neurological diseases with special reference to rabies.

A retrospective study of horses necropsied between 1985 and 1989 at a diagnostic laboratory of a veterinary school in North America is documented. In this investigation over 20 per cent of the horses had clinical neurological signs. Equine protozoal myeloencephalitis (caused by Sarcocystis neurona) and cervical stenotic myelopathy (wobbler syndrome) were the most common of these disorders. The veterinary school is located in the midst of a raccoon rabies enzootic area. However, only four cases of equine rabies were diagnosed during the 5-year study. The gross microscopical and immunohistochemical findings from these rabies-positive horses are documented. Immunoperoxidase tests for detection of rabies antigen in another 35 horses with non-specific encephalitis/encephalopathy did not reveal any positive cases. Based on this investigation, it appears that immunoperoxidase is a valid method for diagnosis of rabies when fresh tissues are not available for the fluorescent antibody test. It is also concluded that no cases of equine rabies were overlooked by the diagnostic laboratory during the period under investigation.

Animals↗
PubMed1992

Esophageal motor disorders: videofluoroscopic and manometric evaluation--prospective study in 88 symptomatic patients.

Esophageal motor disorders are best evaluated with manometry, which, however, is time-consuming and not generally available. The authors prospectively investigated the yield of videofluoroscopy in detection of esophageal motor disorders in comparison with that of manometry. Eighty-eight patients with dysphagia, globus sensation, noncardiac chest pain, or progressive systemic sclerosis underwent both manometry and videofluoroscopy at 0-32-day intervals. Videofluoroscopy was performed with one swallowing study in the upright position and up to three swallowing studies in the prone oblique position. Manometric diagnoses of achalasia (n = 15), diffuse esophageal spasm (n = 1), nonspecific esophageal motor disorders (n = 44), and adynamic esophagus (n = 9) were made. Videofluoroscopically, 87% of the patients with achalasia, the one patient with diffuse spasms, 73% of the patients with nonspecific esophageal motor disorders, and all of the patients with adynamic esophagus received a correct diagnosis, for an overall sensitivity of 80%. The radiographic specificity was 79%. The authors conclude that videofluoroscopy is a valuable and reasonably sensitive technique for screening for esophageal motor disorders.

Adolescent↗
PubMed1992

Morphologic and immunoperoxidase study of neurologic lesions in naturally acquired rabies of raccoons.

Histopathologic (hematoxylin and eosin [HE]) and immunoperoxidase (streptavidin-biotin complex) methods were used for examination of formalin-fixed tissues of rabid raccoons from an enzootic area of Pennsylvania. Extensive morphologic lesions of rabies encephalitis were present in the cerebrum and the brain stem regions. Negri bodies were detected by both methods and were present in the brain (cerebral cortex, hippocampus, brain stem, cerebellum, and cervical spinal cord) and in the ganglia of the trigeminal nerves. The viral inclusions were also seen in ganglion cells in the tongue, parotid salivary glands, pancreas, intestines, and adrenal glands. These sites were not associated with any inflammatory cellular infiltrate. The immunoperoxidase method was superior to HE for the detection of Negri bodies. Because lesions of rabies encephalitis were consistently observed in the cerebrum, brain stem, and cervical spinal cord regions, these areas of the brain should be included when raccoons are examined by the fluorescent antibody test for rabies.

Animals↗
PubMed1991

Pharmacokinetics of alprazolam in geriatric patients with neurotic depression.

The pharmacokinetics of alprazolam was studied in 10 geriatric patients (5 males, 5 females) with neurotic depression during a 6-week period. After 0.5 mg of alprazolam on Day 1 the mean elimination half-life was 11.1 hr and Cmax 12.3 ng/ml. The pharmacokinetic evaluation on Day 1 (t 1/2, tmax) did not differ significantly from the evaluation on Day 42. The mean daily dosage on Day 42 was 1.6 mg alprazolam. The concentrations of the metabolites alpha-OH alprazolam and 4-OH alprazolam were less than 10% of that of alprazolam. All the patients improved clinically. The most common side effect was drowsiness, more often during the first week than the last week.

Aged↗
PubMed1979

[Esophageal leiomyomas. Apropos of 16 cases].

16 cases of oesophageal leiomyomas are reported; diagnostic difficulties and important surgical consequences are discussed. The surgical procedures must be as soon as possible, and should be enucleation of the lesion. The results are excellent. In three cases postoperative oesophageal spasms and retrosternal pains needed secondary medical treatment.

Adult↗
PubMed1979

[Training possibilities for surgical interns].

Two questionnaires were prepared and adressed to interns in all surgery clinics in Switzerland. They trend to determine opinions on the actual formation in surgery. The results appears that, if a good formation may be obtained, the "postgraduate" has to be considered nowadays as the forgotten child in the hospitals. Important effort must be envisaged, to ameliorate the structuration of the post-graduate teaching, between and in the hospitals, but also to determine ways to inspect his quality.

Adult↗
PubMed1978

[Sociological studies in acne vulgaris. 2. Effect of the disease on the evaluation of clinical picture and motivation for therapy].

A questionnaire was presented to 2009 18--19 year old recruitment candidates. The questionnaire enabled appraisal of antipathy towards patients with severe acne vulgaris and the occupational inpediment of severe acne. It was shown in comparison of patients with clinically relevant acne and healthy subjects or patients with a minor variant of acne that acne patients are more prepared to tolerate other acne patients than are healthy subjects. A questionnaire which enabled appraisal of attitudes to therapy was presented in addition to 351 patients with clinically relevant acne in this collective. The schools attended were also recorded in these patients. It was shown that the motivation to undergo treatment can be assumed in only half of the acne patients; this motivation is less the more radical the therapy. However, the motivation is greater the higher the educational level of the person questioned.

Acne Vulgaris↗
PubMed1978

[Sociologic studies in acne vulgaris. 1. Disease significance of acne vulgaris].

A questionnaire was presented to 2009 18--19 year old military recruitment candidates which enabled assessment of antipathy towards patients with severe acne vulgaris, the occupational handicap associated with severe acne and subjective inhibitions in acne patients. In addition, these persons were examined clinically with regard to presence of acne vulgaris. Finally, the level of education of the persons questioned was determined. The investigations show that severe acne has an appreciable disease rating. This results from antipathy of other people, the occupational inpediment and the psychological inhibitions of the acne patient. This disease rating appears to be objectively greater the lower the level of education of the acne patient. The disease rating does not appear to be entirely clear to the acne patient with a low level of education.

Acne Vulgaris↗
PubMed1978

[Audiological evaluation of ototoxicity in gentamycin-treated children (author's transl)].

Audiological evaluation was performed on 36 children who had been treated with gentamycin for severe infections of the urinary tract and/or of the bronchopulmonary system. An average of three years had elapsed between medication and audiological testings. Only one child showed a slight degree of symmetrical sensoneural hearing loss in the high frequency range.

Age Factors↗
PubMed1978

[Primary stenosing cholangitis].

Five cases of sclerosing cholangitis are recorded from 3697 biliary operations. Two patients had a cancerous course and 1 associated ulcerative colitis. The first two cases could be classified as primary sclerosing cholangitis. They are described. The pathogenetic mechanisms and treatment of this affection are discussed.

Adenocarcinoma, Scirrhous↗
PubMed1978

[Volvulus of the colon].

Twenty-two cases of volvulus of the colon are reported. The conservative and surgical methods of treatment are discussed. It should be emphasized that a preliminary X-ray study of the colon with Gastrografin is necessary to identify the nature and site of obstruction and any associated lesions.

Aged↗
PubMed1978

[Pleural empyema and Tauroflex. Study of a new bactericidal agent].

A pilot study of 8 cases of lung empyema treated with taurolin, a new bactericidal agent, is reported. Rapid sterilization of exudates and favorable clinical course are discussed. Thanks to the absence of toxicity and its bacteriological efficacy, taurolin is a useful therapeutic agent in pleural empyema. Its use in the prophylaxis of complications in thoracic surgery is suggested.

Anti-Infective Agents, Local↗
PubMed1978

Sporozoites of rodent and simian malaria, purified by anion exchangers, retain their immunogenicity and infectivity.

Sporozoites of rodent malaria, Plasmodium berghei, and simian malaria, Plasmodium knowlesi and Plasmodium cynomolgi, were partially separated from mosquito debris and microbial contaminants by passage of Anopheles material through a DEAE-cellulose column. In addition to eliminating most of the contaminants (80-90%), this simple technic has made it possible to recover rapidly large numbers of viable sporozoites (55-75% yield), which have retained their infectivity, immunogenicity, and capacity to react with known antisera. Mice injected with varying doses of column-purified sporozoites (CS) of P. berghei produced infections which paralleled those seen in the controls. Total protection against challenge with a potentially lethal dose of viable sporozoites was acquired by mice inoculated twice with irradiated CS of P. berghei CS of P. berghei and P. cynomolgi gave positive circumsporozoite precipitation (CSP) reactions, upon inoculation with the respective immune sera. The preservation of the surface antigens of CS was documented by immunofluorescence. It was shown that differences in elution behavior exist among sporozoites of certain species of Plasmodium as well as among sporozoiters of the same species derived from different organs of the mosquito. These results may be attributed to differences in the surface charge of the sporozoites or conditions in sample media. Purified sporozoites obtained by the method described in this report provide an adequate source of parasites for a variety of in vitro studies.

Animals↗