[Critical evaluation of the surgical treatment of 600 lumbosciatica cases. Diagnostic and therapeutic trends].
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Back Pain↗
Biomedical subjects
G Moretto
Publications and source records attributed to G Moretto.
Friedreich's ataxia. A light- and electron microscopic study of peripheral nerve biopsies.
Sural or superficial peroneal nerve biopsies of patients with clinical diagnosis of Friedreich's ataxia were studied. Patients were divided in two groups, typical and abortive forms: loss of fibers accompanied by axonal atrophy and segmental demyelination are the basic changes in both groups, although the decrease in number of myelinated fibers was most severe in typical FA. In the cases with slower progression there is a tendency to form onion bulb complexes.
Atrophy↗
Modulation of antigenic expression in cultured adult human oligodendrocytes by derivatives of adenosine 3',5'-cyclic monophosphate.
Oligodendrocytes were isolated from adult human brains obtained at autopsy by enzyme treatment - Percoll density gradient centrifugation, and grown in culture. During the first week in vitro, these cultures consisted of an enriched population (93-98%) of galactocerebroside-immunoreactive oligodendrocytes. After 2 weeks and onward, a large number of GFAP-positive astrocytes and glial cells doubly positive for galactocerebroside and GFAP markers was found among the oligodendrocytes. When these cultures were exposed to dibutyryl cyclic AMP, 8-bromocyclic AMP and RO-1724, an inhibitor of cyclic nucleotide phosphodiesterase, for 4-14 days, the majority of cells returned to express oligodendrocytic phenotype. These findings suggest the presence of heretofore unidentified "transitional" or "bipotential" glial cells in human brains that express both oligodendrocytic and astrocytic phenotypes, and the regulatory role of cyclic AMP derivatives which may induce a stable antigen expression in oligodendrocytes.
8-Bromo Cyclic Adenosine Monophosphate↗
[Rare colonic occlusions: volvulus of the splenic flexure].
Authors report a case of perforated splenic flexure volvulus, treated with resection, end colostomy and closure of the distal stump. From the revision of literature it comes out the case reported is the 30th recorded till now, the 6th with ischemic complications, and the only one with perforation. Actual pathogenetic trends and various therapeutic options are reported.
Colonic Diseases↗
Peripheral and central nervous system involvement in essential mixed cryoglobulinemia: a case report.
We describe a man with essential mixed cryoglobulinemia who developed peripheral neuropathy and multiinfarctual encephalopathy. Vasculitis was observed in the vasa nervorum and in the small vessels of the brain. The possible pathogenetic role of the cryoglobulins in the nervous system lesions is discussed.
Cerebral Infarction↗
[Australian method of first aid for European snake bites. Spreading its use in Italy].
Antiquated first-aid procedures, such as the incision and sucking of the wound and the application of a tourniquet, are still used in Italy consequent to the bite of vipers. The A. hope that such procedures will be finally abandoned, since they are ineffective, impractical, painful and can furthermore produce invalidating or disfiguring permanent outcomes. In this report they extensively describe Australian first-aid measures consequent to snakebites, constituted by a compressive bandage and by immobilization of the bitten limb by splinting. They hope therefore that the divulgation of this procedure in Italian will bring about, within a short period of time, its extensive use in Italy consequent to viper bites, as it is very effective, practical and easy to carry out.
Australia↗
[Peripheral nerve biopsy. Indications, methods and principal pathological pictures].
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Biopsy↗
[Value of urinary cytology in the diagnosis of urothelial carcinoma of the pelvis and ureter].
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Carcinoma, Transitional Cell↗
Cytoskeletal pathology in ataxia-telangiectasia.
Neuropathological features of a case of ataxia-telangiectasia are reported. The main findings were the presence of Lewy bodies, cytoplasmic inclusions and axonal spheroids in the brainstem nuclei; pathological changes of spinal cord closely resembled those reported in the familial form of amyotrophic lateral sclerosis. In immunocytochemical studies, filamentous inclusions and axonal spheroids strongly reacted with monoclonal antibodies against neurofilament subunits. The results show that disorganization and accumulation of neurofilament proteins occur in ataxia-telangiectasia.
Adult↗
[Hypertrophic neuropathies beginning in infancy: a study of 3 cases (author's transl)].
The genetical forms of hypertrophic neuropathies, inherited either as recessive or autosomal dominant trait, are classified, according to Dyck (1975), as HMSN type I, III, and IV. Sporadic cases are also reported. We studied three patients, one with autosomal recessive inheritance, and two without family history, who had the following common features: --onset of symptoms before the age to two years; --slowly progressive course; --peroneal muscular atrophy with absent tendon reflexes; --reduction of MCV and SCV; --decreased number of myelinated fibers; --schwannian cell hyperplasia, with onion bulb complexes formation; --absence of aspects of hypomyelination; --increased number of collagen pockets and denervated Schwann-Remak cells or processes. On light microscopy, multilamellated onion bulbs of large size were found in a very high percentage in case 1, while there were either simple in type or in a lower percentage in case 2. In the third, case, onion bulbs were recognized only on electron microscopy. It is known that in the various kinships affected with type I of HMSN, the pathological changes of peripheral nerves differ greatly. Therefore, despite early onset of symptoms and varying degree of severity of nerve changes, all three cases have been classified within the group of HMSN type I. The different severity of nerve damage may suggest the possibility of a genetical heterogeneity in this disorder.
Adolescent↗
[Histopathologic and ultrastructural study of various amputation neuromas].
The results of a light and electron microscopy study of seven amputation neuromas are presented. The neuromas were removed during surgery for traumatic lesions of limbs. The histological study showed a complete disappearance of the nerve architecture at the neuroma level, where the fibres are collected in small bundles, enveloped in an abnormal perineural sheath, surrounded by an overgrowing connective tissue. In two cases a partial and incomplete reinnervation of the distal stump was found. The ultrastructural study shows abnormalities of the nervous fibers, both of the axon and of the relationships between the axonal part and the Schwann cell. The results of our data in man are compared to nerve regeneration patterns recently investigated in experimental models.
Adolescent↗
[Evaluation of the tolerance of a lipid emulsion administrated during total parenteral nutrition in surgical patients].
Tolerance's evaluation of a lipid emulsion given in course of parenteral total nutrition in surgical patient's. The first fat emulsions for intravenous application were thrown on the market in the 1920's years. Authors make a study on a limited sample of surgical patients about type and incidence of both immediate and late adverse reactions versus intravenous administration of Lipofundin S. They also suggest, on the same time, a protocol for the survey of these reactions. The results suggest a good tolerance to Lipofundin S intravenous administration and no influence on haematic biochemical parameters.
Adult↗
Cytoskeletal changes and ubiquitin expression in dystrophic axons of Seitelberger's disease.
Central nervous system specimens of 4 cases of Infantile Neuroaxonal Dystrophy (Seitelberger's disease) were processed for Bodian's silver stain and for immunostaining with antibodies against neurofilaments (NF), tubulin and ubiquitin (UBQ). Reactivity to NF and UBQ was restricted to spheroids of small size; swellings larger than 30 mu were negative, in spite of their positivity to Bodian's silver stain. Reactivity to tubulin was evident only in normal fibers, whereas no positive material was observed in dystrophic axons. These findings suggest that loss of microtubules (MT) and denaturation of NF might play a crucial role in the mechanisms responsible for the formation of axonal spheroids; in addition the focal activation of the UBQ system suggests an attempt of the neuron to remove abnormal material even at sites remote from the perikaryon.
Axons↗
[Gastric cancer. Which resection?].
BACKGROUND: The choice of surgical technique in antral gastric cancer is still debated. Some authors support total gastrectomy in all cases. In recent years there is a trend to use total gastrectomy only if strictly necessary. Total gastrectomy allows a large lymph node excision, with better oncological results. The mortality rate and post-operative complications are quite similar today after gastric resection. Anyway, if exact histological diagnosis is possible and at least 6 cm unaffected tissue is preserved, oncological cure is possible by gastric resection. METHODS: Personal experience in 224 patients operated on from 1975 to 1994 is reported. RESULTS AND CONCLUSIONS: 54.3% had antral gastric cancer, 16.5% body cancer and 8.7% fundus gastric cancer. Subtotal gastric resection should be the surgery of choice in antral gastric cancer. Early subtotal gastrectomy with R2, Advanced (III and IV-TNM) only resection with R2, and Advanced (II-TNM) total gastrectomy with R3.
Aged↗