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Biomedical subjects

G Moreno

Publications and source records attributed to G Moreno.

151 records · Page 9Linked to original sources
PubMedDate not supplied

[Isolation of Salmonella from marine shellfish].

The present paper reports the isolation of Salmonella from oysters and clams encountered in the marine waters of Santos and destined to the human consumption. The results obtained showed the characterization of 41 (59,43%) strains of Salmonella arizonae and 28 (40,57%) of Salmonella typhimurium, by its cultural biochemical and serological properties. The drug resistance of Salmonella to several antibiotics was also investigated by determining the minimal inhibitory concentration in serial agar plate dilutions of the therapeutic agents.

Animals↗
PubMedDate not supplied

Prognostic significance of preoperative serum CA 19.9 assay in patients with colorectal carcinoma.

The prognostic information provided by preoperative serum CEA and CA 19.9 antigen assay on the postoperative outcome of 150 patients with colorectal cancer was analysed. The influence of both markers was studied by Cox's proportional-hazard regression analysis. In the univariate analysis, patients whose initial CA 19.9 level was higher than 37 U/ml had a 4.32-fold greater risk of death due to the cancer (95% CI: 1.72-10.84) (p < 0.001) than patients with lower values. The 36-month survival rate posttreatment was lower for patients with CA 19.9 serum levels over 37 U/ml (61% versus 90%) (p < 0.001). Patients whose initial CEA level was higher than 5 ng/ml had a 2.9-fold greater risk of death (95% CI: 1.05-7.99) (p = 0.04) than patients with lower values. The 36-month survival rate posttreatment was lower for patients with CEA serum levels over 5 ng/ml (84% versus 76%) (p = 0.04). After adjustment for Dukes' stage, CEA, CA 19.9, tumor site, sex and age, only Dukes' stage and CA 19.9 continued to provide independent predictive information on survival. The risk of death increases by 1.008 for every 10 U/ml rise in the level of the marker (95% CI: 1.002-1.014) (p = 0.009). With respect to analysis of disease-free survival, only Dukes' stage provided independent predictive value. CA 19.9 is an independent prognostic factor of survival in colorectal cancer. The authors suggest including CA 19.9 in a future multifactorial analysis of survival.

Age Factors↗
PubMedDate not supplied

[Role of renal interstitial pressure on chronic control of arterial blood pressure].

Several lines of evidence support the hypothesis that the kidney is involved in the generation and maintenance of arterial hypertension. The evidence comes from: 1) experimental models of hypertension showing that induction of all secondary forms of hypertension require some maneuvers to reduce the renal sodium and water excretion; 2) the existence of several rat models with genetic hypertension exhibiting a shift of the pressure-natriuresis relationship toward higher pressures; 3) renal transplantation experiments between normal and genetically hypertensive rats showing that hypertension follows the kidney; and 4) human genetic disease with chronic changes in arterial blood pressure levels in which all identified genes so far are part of a common pathway for renal sodium reabsorption. It is well known that pressure-natriuresis is the mechanisms by which any changes in arterial pressures are followed by changes in renal sodium excretion. However, it has been recognized now that the interstitial pressure in renal medulla is the linkage between arterial pressure levels and the amount of sodium reabsorption. Thus, the medullary interstitial pressure might be involved in the long-term control of systemic arterial pressure. Part of these new lines of evidence associating the renal medullary interstitial pressure in the control of arterial pressure are due to the availability of new methods such as laser-doppler flowmetry and videomicroscopy, that allows the measurement of blood flow in renal cortex and medulla separately. Several studies with this methodology show that medullary, but not cortical pressure and blood flow correlate positively with natriuresis. What still remains unsolved is the mechanism by which renal sodium reabsorption increases or decreases after changes in the medullary interstitial pressure occur.

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