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Biomedical subjects

G Morata

Publications and source records attributed to G Morata.

69 records · Page 4Linked to original sources
PubMed1979

Bristle patterns and compartment boundaries in the tarsi of Drosophila.

We describe cell lineage of the tarsus of wild-type Drosophila. Large Minute+ clones were made to map the position of the antero-posterior compartment boundary in all three tarsi. The tarsus is mirror symmetric, but the compartment boundary does not coincide with the mirror plane. This boundary runs along the dorsal and the ventral rows of bristles which are immediately posterior to the mirror plane; elements in these rows being made by both anterior and posterior polyclones. The provenance of bristles and bracts suggests that the bristle cells move into their final positions. The homoeotic mutation engrailed affects only the posterior compartments of all three tarsi. The mutations bithorax and postbithorax affect only the anterior and posterior compartments of the third legs, respectively, transforming them into homologous compartments of the second leg. These results support the selector gene model of development (Garcia-Bellido, 1975) and emphasize that collaboration between polyclones is important in pattern formation.

Animals↗
PubMed1975

Analysis of gene expression during development in the homeotic mutant Contrabithorax of Drosophila melanogaster.

Contrabithorax, a mutant of the bithorax system in Drosophila melanogaster produces a partial homeotic transformation of mesothorax (wing) into methathorax (haltere). The wing of a fly homozygous or heterozygous for the mutant is a mosaic of wing and haltere structures. A genetic analysis of the mutant suggests that its phenotype is due to some form of derepression in the wing of two other genes of the bithorax system (bithorax and postbithorax) which are not normally active there. This repression is not complete. The activity of the two genes is below the normal level resulting in only a partial transformation of wing into haltere. Clones of marked cells were generated by X-rays and were found to include both transformed (haltere) and untrasformed (wing) territory; this was true even for those generated late in development. Thus the final expression of a cell depends not on its immediate ancestry but perhaps on the level of the products of the wild-type alleles of bithorax and postbithorax.

Animals↗
PubMedDate not supplied

Genetic organization of Drosophila bithorax complex.

The Drosophila bithorax complex is subdivided into three major genes: Ultrabithorax+, abdominal-A+ and Abdominal-B+. Each of these genes plays its principal part in a particular anatomical domain of the body, where it is specifically required to determine the correct segmental pattern.

Animals↗