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Biomedical subjects

G Morack

Publications and source records attributed to G Morack.

At least 19 recordsLinked to original sources
PubMed2000

Necrotizing small-vessel vasculitis confined to the uterine cervix.

OBJECTIVES: To report our experience with five cases of apparently isolated small-vessel vasculitis of the uterine cervix. METHODS: Case study of five patients with necrotizing vasculitis discovered incidentally in surgical specimens of the female genital tract, and a review of the pertinent literature on this subject. RESULTS: All patients lacked clinical and serological features of the well-delineated vasculitic syndromes. Comprehensive workup failed to yield any evidence of an underlying disorder. All patients were managed expectantly and did not develop systemic vasculitis during follow-up ranging from 6 months to 5 years. CONCLUSIONS: Isolated vasculitis of the female genital tract can be encountered as an innocuous finding in otherwise healthy individuals. The cause and pathogenesis of this disorder remain obscure. Rheumatologists should be familiar with this rare and vexing form of vasculitis and with its benign prognosis.

Adult↗
PubMed1999

[In Process Citation]

OBJECTIVE: The objective of this retrospective analysis was to compare the obstetrical procedures at premature birth and delivery at term. The aim was to show the influence of gestational time on mode of delivery and neonatal state. MATERIAL AND METHODS: 339 births from breech presentation between 1988-1990 were compared with premature births and deliveries at term. RESULTS: Frequency of breech presentation totalled 4.1%. 173 deliveries (51.7%) resulted vaginally, 26 cases (7.8%) with freeing of arms and 4 cases (1.2%) as extraction. Frequency of cesarean sections totalled 48.3%. The number of premature births reached in the group of breech presentation 23.1%. Births at term resulted with 58% predominantly vaginally (abdominally in 42%). Between the 31st and 36th gestational week the number of cesarean sections rose to 67.3%, in the 31st week it even reached 78.9%. The neonatal state was described with the help of Apgar-scores and umbilical cord-pH-values. The share of newborns with optimal Apgar-values after 1 minute (8-10) was in premature births with 36.5% only about half as large as in deliveries at term (77.6%). Only 9.6% of the children showed pH-values below 7.20. Number of newborns with these pH-values totalled in premature births in the 31st week 35.3%, for terms between the 31st and 36th week 15.6%, and declined in mature births to only 6.2%. CONCLUSIONS: Estimating the neonatal state of the group of breech presentations the vaginal birth should keep an equal rank in the delivery plan of a clinic. At the appraisal of the childlike early morbidity of a delivery group the number of premature newborns is decisive.

Journal Article↗
PubMed1998

Controlled multicentre study of the influence of subcutaneous recombinant human erythropoietin on anaemia and transfusion dependency in patients with ovarian carcinoma treated with platinum-based chemotherapy.

This randomised controlled multicentre trial evaluated the effectiveness of recombinant human erythropoietin (rhEPO) in preventing anaemia and reducing the need for blood or erythrocyte transfusion in 122 ovarian cancer patients receiving platinum-based chemotherapy. The patients were randomly allocated to receive rhEPO 150 U/kg or 300 U/kg subcutaneously, three times a week, or open control. Patients also received up to 6 cycles of carboplatin or cisplatin, alone or in combination with other cytotoxic agents. Intention-to-treat analysis showed that 39.4% of patients in the control group received at least one blood transfusion, compared with 9.2% of patients treated with rhEPO. Patients treated with rhEPO experienced a significantly longer time to first erythrocyte transfusion than the control group and were less likely to experience nadir haemoglobin levels < 10 g/dl (P < 0.001 and < 0.05, respectively). A haemoglobin decrease < 1 g/dl during the first chemotherapy cycle, as well as a low baseline serum erythropoietin concentration, predicted a low transfusion need in rhEPO-treated patients but not in controls. During the study, 103 patients suffered at least one adverse event, but no serious, and only nine non-serious adverse events were considered possibly related to rhEPO therapy. These results indicate that treatment with rhEPO prevents anaemia, it reduces the need for blood or rhEPO erythrocyte transfusion in patients with ovarian cancer receiving platinum-based chemotherapy, and it is well tolerated. A starting dose of 150 U/kg of rhEPO, three times a week, may be recommended.

Anemia↗
PubMed1996

[Prognostic factors and results of treatment in endometrial carcinoma].

158 patients with endometrial cancer who were treated between 1980-1990 at the Department of Obstetrics and Gynecology, Hospital Berlin-Buch, were reviewed retrospectively with regard to prognostical and therapeutical aspects. The 5-year-survival rate of all patients amounted to 84%. The 5-year-survivals were 92.6% for stage I, 87.5% for stage II and 47.6% for stage III (old FIGO classification). Depth of myometrial invasion, lymph-vascular space involvement, lymph-nodal status, tumor type and grading are of dominant prognostic value. Surgery was the treatment of choice in all reviewed cases. No statistically significant difference was observed in the 5-year survival rate between vaginal and abdominal hysterectomy. The 5-year survival rate for cases with vaginal hysterectomy was 85.4% and for abdominal hysterectomy 87.8%.

Adult↗
PubMed1995

[Evaluation of epidemiologic risk factors for endometrial carcinoma based on a case-control study].

In a case-control-study an epidemiological investigation of cancer of the endometrium was carried out. The study included 159 cases and 159 controls. It was shown, that woman in the sixth life decade with overweight, a smaller number of deliveries and a later menopause had a higher risk for endometrial cancer. Other risk factors are diabetes mellitus and hypertension. But it is necessary to see the relationship between the typical age for these two characteristics and the typical age for endometrial cancer. The intake of estrogens without enough gestagens during an estrogen replacement therapy was associated with an increased risk. Furthermore the patients with carcinoma of the uterine corpus had a higher incidence of malignant tumors in their families and more breast cancer in their own case history. A history of oral contraceptive use appeared to reduce the risk of endometrial cancer. In addition there is an negative association between smoking and endometrial cancer. Thus factors of high risk related to cancer of the endometrium could be defined. Preventive examinations of high risk groups could help to decrease the incidence of endometrial cancer.

Adult↗
PubMed1994

[Fathers in the delivery room--an East/West comparison].

The attendance of fathers in the delivery room to accompany the women giving birth is in Germany quite common. In this study we wanted to compare the results of a questionnaire on feelings, intention an anxiety of attending fathers in an east and west German maternity hospital. Although social acceptance of fathers in the delivery room in the eastern part of Germany is delayed by 10 years (compared to western clinics) the over all impression of attending fathers was similar. We aid find differences concerning the expectations, the way of mental preparing and considerations participating the approaching birth in east and west questionared fathers. The results also showed variable knowledge in respect of pregnancy and birth. We do think that after a time of ("father") experience in the east part of Germany the expression of opinion will adjust.

Adult↗
PubMed1990

[Effectiveness of cisplatin alone and in combination within the scope of primary therapy of ovarian cancer. Results of a prospective multicenter study].

The efficiency of cis Platin (DDP) alone and in combination with Adriamycine (ADM) and Cyclophosphamid (CTX) were evaluated in a prospective randomized trial containing 173 pat. suffering from advanced ovarian cancer (FIGO III/IV). Therapeutic schedule and results: (table; see text) The most side effects concerned vomiting (WHO Grad 2) in 90%, nausea (WHO Grad 2) in 95% and alopecia in 50% out of all pat.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1989

[C-reactive protein in the maternal serum and risk of maternal infection in premature rupture of the fetal membranes and threatened premature labor].

For diagnosis of ascending intra-uterine infections, regular controls of the serum CRP levels were carried out in 129 patients with premature rupture of membranes and impending premature labour. The height of the maternal CRP level and the simultaneously determined leucocyte counts and band counts were compared with the peripartal fever morbidity (intrapartal fever, puerperal fever). It was established that patients who had a prepartal CRP level of 10 mg/l or more suffered febrile complications more frequently (fever morbidity 18.2%) than females in whom such high CRP values did not occur (fever morbidity 3.4%). Similar correlations existed between the other parameters tested and the fever morbidity, and subclinical intrauterine infections were recognized with higher reliability if CRP, leucocyte count and band count had been determined in combination.

C-Reactive Protein↗
PubMed1989

[C-reactive protein in the maternal serum and risk of fetal infection in premature rupture of the fetal membranes and threatened premature labor].

In order to find out whether, in the framework of our obstetrical management, determinations of the C-creative protein (CRP) in maternal serum enables recognition of incipient intra-uterine infections, regular controls of the CRP level were performed in 129 patients with premature rupture of membranes and impending premature labour. The maternal CRP levels and the simultaneously determined total leukocyte counts and band counts were compared with the frequency of neonatal infectious diseases up to the 3rd day of life. None of the infants were affected whose mothers never had values above 10.0 mg/l. If he maternal CRP values exceeded the 10.0 mg/l limit, then 6.3%-57.1% of the newborns were affected depending on their birth weight. Therefore, the prepartal CRP diagnosis can, especially in infants with low birth weight, help to determine the risk of infection.

C-Reactive Protein↗
PubMed1989

[Rapid determination of C-reactive protein using latex agglutination].

A simple and fast Latex agglutination assay for the determination of C-reactive protein (CRP) is described. The decision range of the assay presented is 7 mg/l; the measuring range extend from 7 mg/l up to 8,000 mg/l. Presented assay allows the cyto-determination of CRP in clinical routine work and therefore is suitable for the early diagnosis of infections in gynecology and obstetrics.

C-Reactive Protein↗
PubMed1986

[Serum sialic acid levels in cancer, pregnancy and upper respiratory infections].

A significant increase in sialic acid content is demonstrable in the sera of cancer patients. Our investigations were performed to find out whether the serum sialic acid level is altered also during pregnancy or with infections of the upper respiratory tract. Our results have revealed a slight increase in sialic acid level to occur only in the last trimester of pregnancy. However, this distinct, though statistically insignificant, increase will not lead to misjudgement in regard to cancer diagnosis, or in case control of this disease. By contrast, in 7 out of 15 patients with infected upper respiratory tract the sialic acid content was clearly above the tolerance limit so that false positive findings may possibly be obtained.

Abortion, Threatened↗
PubMed1984

[Screening for endometrial carcinoma in a group at risk].

In a population-based study 923 asymptomatic women with diabetes aged 40 to 70 years were investigated by aspiration curettage. The samples were evaluated histologically. During the initial screening 4 histologically proved endometrial cancers were diagnosed. All cancer patients were additionally obese and had hypertension, with one exception they were also nulliparous. During the same period the expected number of cases for all investigated women was estimated to 0,74. The expected number of cases limited to those with diabetes, obesity and hypertension was 0,31; and limited to those with diabetes, obesity, hypertension and nulliparity was 0,1, respectively. Additionally 4 cases of adenomatous hyperplasia of the endometrium were identified. The long-term impact on morbidity and mortality of endometrial cancer within the investigated population at risk cannot be assessed as yet.

Adult↗
PubMed1982

[Malignant neoplasms of the uterus in the capital city of East Germany, Berlin, in the period from 1975 to 1979].

Some important data characterizing the situation in endometrial cancer control during the period from 1975 to 1979 in the capital of the German Democratic Republic, Berlin were analyzed. The analysis demonstrates a further increase of the standardized incidence rate to 23.2/100,000. The increase is strictly limited to the age-groups between 65 and 80. The mortality rate decreased to 7.3 100,000. Further progress in endometrial cancer control can be demonstrated by an increase of cases detected in stage I (68%) and a significant increase of the 5-Year-Relative-Survival-Rate (1965 to 1968: 69%/1975-76: 77%). During the period analysed there was an marked increase of patients treated by radical surgery or radical surgery plus radiotherapy and a decline of patients treated by radiotherapy alone. Some conclusions are drawn concerning the further improvement of prevention, early detection and treatment of endometrial cancer.

Adult↗
PubMed1982

[Oestradiol receptors in endometrial carcinomas (author's transl)].

Tissue samples taken from endometrial carcinomas as well as from normal and hyperplastic endometria were tested for oestradiol receptors. Roughly one and the same amount of receptors was recordable from all three tissue groups. In premenopausal women, receptor levels were lowest in the advanced phase of secretion. All tumour patients so far have survived without recurrence. Therefore, no correlation has been established, as yet, between receptor level and prognosis, in a way similar to what has been found in cases of mammary carcinoma.

Adult↗
PubMed1982

[Clinical experience with the depot estrogen Turisteron in the treatment of metastatic breast cancer (author's transl)].

Turisteron is a depot estrogen with an average biological half-life of six days. It has the advantage compared to other oral estrogens that it can be administered once a week p.o. Forty late postmenopausal patients with metastatic breast cancer received Turisteron. Overall 19 (47,5%) had a positive response. An objective remission rate (tumor regression of greater than 50%) was achieved in 12 patients (30%). To date the mean duration of response is 27 months for complete remissions and 10 months for partial remissions. The risk-response relationship for Turisteron in older patients is favourable compared to that of polychemotherapy and it is therefore recommended that Turisteron be used as the initial therapy of choice for patients with metastatic breast cancer who are more than 5 years postmenopausal. Indications and contraindications for Turisteron are discussed in detail.

Aged↗
PubMed1981

Cellular sensitization in man and mice during pregnancy to fetal antigens as detected by lympholine assays.

Soluble extracts were prepared by the 3 M KC1 method from human mouse fetuses at different stages of development. As shown by macrophage electrophoretic mobility and by leukocyte migration inhibition tests a high percentage of pregnant women is sensitized to components of these extracts. The testing of pregnant mice of an inbred strain gave similar results. The available data support the view that some kind of cellular sensitization to fetal antigen may occur during pregnancy.

Animals↗
PubMed1980

[The therapy of the early ovarian cancer (T1/T2 M0 N0) (author's transl)].

The paper deals with the results of a randomized prospective therapeutic study concerning 60 patients with ovarian cancers in stages T1 M0 N0 and T2 M0 N0 without (A group) and with (B group) postoperative chemotherapy, who had been operated on under a curative objective. The operative approach covered the abdominal exstirpation of the uterus with both adnexa and resection of the omentum. In stage T1 M0 N0 the 5-year survival time was reached by 94% of the patients without follow-up treatment (A group) and 90% of those who received such treatment (B group). In stage T2 M0 N0 all the patients without follow-up treatment (A group) and 76% of those cytostatically treated (B group) survived 5 years. While after a 10-year observation period the therapeutic results have remainded unchanged for stage T2 M0 N0 the survival rate of patients with tumours in stage T1 M0 N0 who hat received follow-up treatment has decreased to 62%. Statistical comparison of therapeutic concepts was not significant (error probability 5%). Attention is drawn to the importance of the operative approach. Ruptured secondura ovarian cancers and ascites do not anymore permit the curative approach and drastically reduce the chances of survival. Present methods of follow-up treatment cannot improve the effectiveness of the curatively performed operative measures take in case of ovarian cancer 5 of stages T1 M0 N0 and T2 M0 N0.

Adult↗