Heat transfer problems during local perfusion in cancer treatment.
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Biomedical subjects
Publications and source records attributed to G Monticelli.
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1. Pronase action on ventral nerve cord ganglia in Bombyx mori L. larvae has been studied from different points of view. 2. Microelectrode penetration in the nervous cell is facilitated by exposure of the tissue to the enzyme. 3. Ultrastructural observations show that pronase action affects mainly the fibrous sheath of the tissue, leading to a partial desheathing of the ganglion. 4. Pronase treatment does not affect significantly the ionic concentrations in the nerve cord.
Lead ions and the surfactant nonylphenolethoxylate are found to inhibit the active transport-coupled water flow in the leg skin of Rana esculenta. The water permeability for osmotically driven flows remains unchanged for high flows, while it is remarkable lowered near zero osmotic pressure difference. The possible mechanism of the permeability change is discussed in connection with the available data on the electrophysiological effects of the pollutants.
The volume flow dependence upon the osmotic pressure difference of both impermeant (sucrose) and permeable (NaCl) species has been investigated in leg skin bags of Rana esculenta. It is concluded: 1. The hydration-dehydration error in the flow measurement with leg skin bags is negligible. 2. The flow-force relationship is non-linear. 3. Unstirred layers and solute permeation have little, if any, influence on non linearity. 4. Structural modifications of the skin induced with hypertonic solutions have been observed and may contribute to non linearity, as well as the multiple-barrier effect.
A method of external fixation with continuous adjustment of stability is described. It allows interfragmentary compression, even on oblique surfaces in any plane and even when applied only on one side of the bone.
A method of classification based upon increase of the anteversion and valgus deformity of the upper femur associated with a dysplastic acetabulum and subluxation of the femoral head demonstrates 4 main groups: I or II in patients 1 to 3 years of age; III, patients approximately 2 years of age; IV, patients with absolute contraindication for surgical intervention. The Monticelli technique employs a Kirschner wire for the internal fixation and incorporates it in a hip spica. The results of the surgical treatment are very gratifying when classification and specified indications are correct. In follow-up observations ranging from 3 to 11 years, with an average of 7 years, there were practically no complications other than a few superficial skin infections.
By means of the Kedem-Katchalsky thermodynamic description of active transport, a relationship has been derived between the apparent reflection coefficient and the Staverman reflection coefficient for passive transport of a solute which is both actively and passively transported. The relationship between volumetric flow and its driving forces, containing the Staverman reflection coefficient, was tested for sodium chloride in rabbit gall bladder and the reflection coefficient was evaluated.
On the basis of our own experience and the most up-to-date reports, we present some of the most controversial features of spondylolysis and spondylolisthesis. In particular, the importance of stress in the etiology of the lysis has been revealed by research carried out on athletes practicing strenuous sports. It has also been shown how the slipping of the olisthesic vertebra does not necessarily cease around the age of 20, but may continue, under certain conditions, even in the young adult. Finally, advice on treatment is given in relation to the various surgical techniques, emphasizing the importance of the reduction of slipping, and giving directions on the use of this technique, and its limitations.
Experimental scoliosis was produced in the rabbit by unilateral electrical stimulation of the paravertebral muscles. The scoliosis was shown to be structural and progressive even after stimulation was stopped. The biochemical and histochemical changes in the intervertebral discs were studied.
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Increasing evidence in the literature indicates that serum sialic acid is increased in cancer patients suggesting a possible usefulness of its determination as a tumor marker. However there are many discrepancies in the data reported, probably due to methodological errors, mainly in lipid bound sialic measurement. In this paper we illustrate the results obtained when we applied a method worked out in our laboratory for the determination of total and fractionated sialic acid (lipid and protein bound) to the analysis of sera from patients with ovarian tumors and the preliminary data on the follow up of selected cases. The potential pitfalls in using this relatively new tumor marker will be critically evaluated.
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