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Biomedical subjects

G Molter

Publications and source records attributed to G Molter.

20 records · Page 2Linked to original sources

[Anesthesia during extracorporeal shock wave lithotripsy].

Three important anaesthesiological methods are considered to be appropriate in anaesthetizing patients undergoing extracorporal shock wave lithotripsy: general anaesthesia, epidural anaesthesia and recently opioid analgesia. In 161 patients who underwent ESWL in epidural anaesthesia, the dosage of the local anaesthetic (bupivacaine 0.5% without adrenaline) was dependent on the level of insertion of the Tuohy-needle and on the age of the patients. Under a sufficient therapy with crystalloids and colloids, cardiovascular parameters such as blood pressure and heart rate remained remarkably stable. In 10 patients the influence of epidural anaesthesia during ESWL on the glomerular filtration rate (GFR) was investigated. After the injection of radio-labelled 51-Cr-EDTA the GFR was significantly reduced by the epidural block. Under the influence of extracorporal shock waves the GFR increased significantly and in some cases exceeded the original value. Opioid analgesia with alfentanil in awake, spontaneously breathing patients is well accepted by patients with kidney stone disease who have to undergo ESWL. The analgesia is achieved by administering an initial bolus injection (30 micrograms/kg) of alfentanil and applying additional injections--each 15 micrograms/kg--on demand. A study with 360 patients was performed in order to investigate the suitability of opioid analgesia during ESWL with special regard to cardiovascular and respiratory depression and other side-effects. Mean systolic and diastolic blood pressure and heart rate were almost not affected. Under insufflation of oxygen by a nasal tube, the mean PaCO2 always showed normal values. Mean PaCO2 increased to 50 mm Hg. A mild drowsiness could be observed in all patients. Two of them developed a complete respiratory arrest accompanied by a muscular rigidity of the chest wall so that respiratory support by mask ventilation became necessary. The "extracorporal piezoelectric lithotripsy" (EPL) is a new method of non-invasive disintegration of kidney stones and can be performed in the non-anaesthetized patient. The efficacy of this much more profitable procedure is equivalent to the ESWL, so that the EPL seems to have a great future.

Adult↗

[Psychosomatic, sedative and hemodynamic reactions following preoperative administration of midazolam in children].

Since children's intellectual perception is limited, the preoperative visit by an anesthesiologist alone can rarely help to free the small patients from fear and restlessness prior to elective surgery. In order to relieve anxiety which should be the primary goal of premedication in any patient - children need anxiolytic premedication agents. Drugs for premedication administered by intramuscular or rectal route in children often cause pain, fear and discomfort. The present study was performed in order to investigate oral given midazolam in the premedication of children with special regard to the practical suitability of this method. 100 children, 0.5 to 10 years of age (group A: 0.5-4 years, group B: 5-10 years) undergoing elective urological surgery received 0.4 mg/kg midazolam orally about 20 minutes prior to the arrival in the operation unit. After insertion of a venous cannula into a forearm vein anesthesia was induced with thiopental and maintained by inhalation with Isoflurane, nitrous oxide and oxygen (fi O2:0.3). Degree of sedation, state of mind and behaviour (for 100 children) as well as blood pressure and heart rate (separately for group A and B) were registered preoperatively at defined, comparable and representative circumstances. Side effects prior and during induction phase of anesthesia were documented. The personal data are representative for a normal population of children with typical urological diseases. Oral administered midazolam had only a mild or non sedative effect in 76-84% of the children 70-84% of the small patients showed an indifferent or euphoric state of mind and 67-88% behaved cooperatively or passively.(ABSTRACT TRUNCATED AT 250 WORDS)

Anxiety↗