Biomedical subjects

G Molino

Publications and source records attributed to G Molino.

At least 73 records · Page 4Linked to original sources

PubMed1980

[Behavior of serum alpha 1-antitrypsin in chronic hepatopathies and its diagnostic significance].

The behaviour of alpha 1 antitrypsin in 76 subjects with cirrhosis of the liver, 14 subjects with chronic persistent hepatitis, 14 subjects with chronic active hepatitis, 8 subjects with toxic hepatitis, 5 subjects with obstructive jaundice, 5 subjects with liver carcinoma. 4 of these groups (cirrhosis, chronic active hepatitis, obstructive jaundice, hepatoma) showed alpha 1 antitrypsin blood levels significantly higher than the control group (82 healthy subjects). Very high alpha 1 antitrypsin blood levels, significantly greater than in cirrhosis, were found in the patients with hepatoma. All these subjects also showed blood levels of alpha fetoprotein higher than 100 ng/ml. The diagnostic meaning of these finding was considered.

Adult↗

PubMed1978

Discrimination of hepatobiliary diseases by the evaluation of bromsulfophthalein blood kinetics.

Blood BSP kinetics was studied by compartmental analysis in 10 normal subjects, 11 cirrhotic patients, and nine patients suffering from obstructive jaundice. Plasma levels of both free and conjugated BSP were determined at different times after intravenous injection of a standard dose (5 mg/kg body weight) of the dye. A six-compartment model was found suitable for the correct evaluation of hepatobiliary function, but simpler models cannot be used in this respect. Some of the parameters of the model can be adequately evaluated in the studied measurement situation and are used to carry out a diagnostic discrimination; they are lambda21 (transfer constant from blood to liver cells), alpha1 (expression of both conjugating and excretory activity), and beta (related to the blood level of conjugated BSP). It is shown that the values of these parameters allow a fairly good separation among the three groups of subjects under study.

Adult↗

PubMed1975

Structural analysis of compartmental models for the hepatic kinetics of drugs.

The structure of some compartmental models for the analysis of the hepatobiliary kinetics of bromosulphalein (BSP) was studied in order to evaluate their adequacy in the estimation of the processes involved in the hepatic metabolism of drugs, namely uptake, conugation, and biliary excretion. Biological measurements were obtained from 4 cholecystectomized patients with a biliary T-tube. Blood and bile specimens were taken at various intervals after the administration of a single intravenous dose of BSP and analyzed for both direct BSP quantitation and chromatographic separation and estimation of BSP metabolic fractions. The structural analysis was carried out by using a mathematical model that described the kinetics of BSP. By means of computer simulations different measurement situations were analyzed, showing for each experimental condition the available information and the degree of accuracy of each estimated parameter. The obtained results show that the use of compartmental models can provide a useful theoretical framework by which the experimental data can be interpreted for the evaluation of the hepatobiliary metabolism and for a discriminant analysis between different physiopathological conditions.

Bile↗

PubMed1974