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Biomedical subjects

G Minisola

Publications and source records attributed to G Minisola.

25 records · Page 2Linked to original sources
PubMedDate not supplied

T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen.

OBJECTIVE: To assess the percentage of T lymphocytes, bearing CD134, a member of the TNF receptor superfamily, primarily found on autoreactive CD4+ T cells in the peripheral blood (PB) and synovial fluid (SF) of rheumatoid arthritis (RA) patients. METHODS: The surface expression of CD134 on SF and PB mononuclear cells was performed by flow cytometry in 25 RA patients and correlated to the disease activity. RESULTS: CD134 expression on CD3+, CD4+, CD8+ and CD25+ cells was higher in SF than in PB of RA patients (P < 0.001). No differences were observed in the percentage of CD134+/CD4+ T lymphocytes in the PB of RA patients and controls. Patients with active RA had significantly higher percentage of CD3+/CD134+, CD4+/CD 134+, CD8+/CD134+ and CD25+/CD 134+ than those with inactive disease. CONCLUSION: These findings suggest that CD134+ T cells are involved in the immunopathological process of RA synovitis, maybe mirroring some other autoimmune disease in which autoreactive T cell infiltrating the target tissues largely coexpress CD134.

Adolescent↗
PubMedDate not supplied

Severe thrombophilia with antiphospholipid syndrome and hyperhomocysteinemia in a patient with Schnitzler's syndrome.

Schnitzler's syndrome is a rare condition with chronic urticaria, intermittent fever, bone pain, and a monoclonal IgM gammopathy. Most patients have a chronic and indolent course, but a small number ultimately progress to a lymphoplasmacytic malignancy. We describe a patient with Schnitzler's syndrome who entered an accelerated phase of clinical deterioration with repeated thromboses of the cerebral and coronary arteries that ultimately led to a fatal outcome. We found that the he fulfilled the Sapporo criteria for definite antiphospholipid syndrome and had elevated blood levels of homocysteine during the active clotting phase of the disease. We suggest that the association with immune-mediated or metabolic disorders, such as the antiphospholipid syndrome and hyperhomocysteinemia, may unfavorably affect the otherwise chronic and stable course of patients with Schnitzler's syndrome. The systemic clotting disorder, the association with the antiphospholipid syndrome and hyperhomocysteinemia, and the biclonal rather than monoclonal IgM gammopathy were striking features of this atypical case of Schnitzler's syndrome.

Antiphospholipid Syndrome↗
PubMedDate not supplied

[Clinical efficacy of sodium diclofenac in chronic juvenile polyarthritis].

We refer the results of an open non-comparative study aimed to evaluate the clinical efficacy of Diclofenac sodium in the treatment of Polyarticular Juvenile Chronic Arthritis. We decided to use this drug to investigate if it exerts also in younger patients the anti-inflammatory and analgesic effects known in adults. We treated 26 patients (14 girls and 12 boys) aged 2-16 years; the disease duration ranged between 3 months and 14 years. Treatment was started only if previous anti-inflammatory drugs had been considered ineffective after a prolonged use (3-12 months). None was on basic therapy. No wash-out period was used for ethical reasons. During the trial period other additional symptomatic or anti-inflammatory drugs were not used. Diclofenac sodium was given by tablets and/or suppositories at the mean daily dosage of 2.4 mg/kg (min. 0.3-max. 5, according to disease activity) for a period of 2-52 months. Diclofenac sodium was particularly effective on joint pain and morning stiffness but also on joint swelling, and functional capacity. We noticed a tendency of JRA to improve during the trial period. The drug was well tolerated; one patient stopped because of headache, another continued the treatment only per os because of intolerance of rectal administration.

Adolescent↗
PubMedDate not supplied

Polyarticular pigmented villonodular synovitis associated with multiple congenital anomalies. A case of Noonan-like/multiple giant cell lesion syndrome.

A case of polyarticular pigmented villonodular synovitis associated with many congenital phenotypic peculiarities (such as shortness, blue sclerae, flattened nose, low-set ears, hypertelorism, curly hair and pulmonary stenosis) is described. The presence of many of the typical signs of the Noonan syndrome and the histological finding of giant cells on the synovial biopsy led to the diagnosis of Noonan-like/multiple giant cell lesion syndrome.

Abnormalities, Multiple↗
PubMedDate not supplied

Atypical renal onset and involvement in primary antiphospholipid syndrome in a child.

A case of primary antiphospholipid syndrome (APS) with renal involvement in a 10-year-old child is reported. The peculiarity of the case resided not only in the apparent "primary" occurrence of APS in the pediatric age, but also in the involvement of the kidney. The renal picture in the case described consisted of a focal proliferative glomerulonephritis, without any sign of glomerular thrombosis. We conclude that this should lead to a consideration of primary APS in the differential diagnosis of nephropathies, also in childhood.

Antiphospholipid Syndrome↗