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Biomedical subjects

G Mielke

Publications and source records attributed to G Mielke.

38 records · Page 3Linked to original sources
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[Vein of Galen malformation: prenatal diagnosis and noninvasive procedure].

In two fetuses a vein of Galen aneurysmal malformation was prenatally diagnosed causing cardiac failure and hydrocephalus associated with marked encephalomalacia. Blood flow in the vena prosencephalica measured by Doppler ultrasonography was extremely high (1290 and 1500 ml/min maximum). In a interdisciplinary council a strictly noninvasive pre- and postnatal procedure was proposed. After adequate information both parents agreed with this approach. The neonates died immediately after birth.

Cerebral Veins↗
PubMedDate not supplied

[Prenatal diagnosis and therapy of feto-fetal transfusion syndrome].

Twin-twin transfusion syndrome (TTTS) is a serious complication of monochorionic twin pregnancies. It is the result of an unbalanced transfusion of blood across placental vascular anastomoses. TTTS appears predominantly in the second trimester of pregnancy characterized by discordance of growth as well as polyhydramnios in the recipient and oligo-/anhydramnios in the donor. Prenatal diagnosis is possible by non-invasive and invasive methods. The prognosis of the untreated TTTS is very poor. Serial amniocenteses and laser therapy are used resulting in survival rates of about 60%. Intrauterine death of one twin is associated with a high risk of morbidity in the surviving twin. Monochroionic twins have to be identified in early pregnancy. Close surveillance is necessary to diagnose TTTS at an early stage of the disease.

Female↗