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Biomedical subjects

G Miceli

Publications and source records attributed to G Miceli.

At least 37 records · Page 2Linked to original sources

Variation in the pattern of omissions and substitutions of grammatical morphemes in the spontaneous speech of so-called agrammatic patients.

We describe the patterns of omissions (and substitutions) of freestanding grammatical morphemes and the patterns of substitutions of bound grammatical morphemes in 20 so-called agrammatic patients. Extreme variation was observed in the patterns of omissions and substitutions of grammatical morphemes, both in terms of the distribution of errors for different grammatical morphemes as well as in terms of the distribution of omissions versus substitutions. Results are discussed in the context of current debates concerning the possibility of a theoretically motivated distinction between the clinical categories of agrammatism and paragrammatism and, more generally, concerning the theoretical usefulness of any clinical category. The conclusion is reached that the observed heterogeneity in the production of grammatical morphemes among putatively agrammatic patients renders the clinical category of agrammatism, and by extension all other clinical categories from the classical classification scheme (e.g., Broca's aphasia, Wernicke's aphasia, and so forth) to more recent classificatory attempts (e.g., surface dyslexia, deep dysgraphia, and so forth), theoretically useless.

Adult↗

Dissociation of inflectional and derivational morphology.

A patient is described who makes morphological errors in spontaneous sentence production and in repetition of single words. The great majority of these errors were substitutions of inflectional affixes. The patient did make some derivational errors in repeating derived words but almost never made such errors for nonderived words. The inflectional errors for adjectives and nouns occurred mostly on the plural forms for nouns and adjectives and on the feminine form for adjectives. For verbs, inflectional errors were produced for all tense, aspect, and mood forms. There were no indications that these latter verb features constrained the form of inflectional errors produced. The results are interpreted as support for the thesis that morphological processes are located in the lexicon but that inflectional and derivational processes constitute autonomous subcomponents of the lexicon.

Aphasia↗

[Antiviral activity of a chemical contraceptive (nonoxynol-9)].

The aim of this study was to evaluate, in vitro, the antiviral activity of a chemical contraceptive (Nonoxynol-9). The results have demonstrated that such a compound is able to inhibit the infectivity of enveloped viruses. It seems that the activity of this contraceptive is due to the lesion of the envelope.

Cell Line↗

Anomia with and without lexical comprehension disorders.

Anomic patients are usually described as free from language comprehension disorders, but the status of lexical comprehension in anomia is still controversial. Most anomic patients are impaired on tasks of semantic-lexical discrimination, but some of them do not present clear signs of semantic-lexical deficit at the receptive level. The aim of the present research was to elucidate the nature of word-finding disturbances by contrasting results obtained by anomic patients with and without lexical comprehension disorders on a number of variables, namely severity of anomia, implicit knowledge of words that patients failed to name, presence of verbal-semantic paraphasias, and scores obtained on a test of phoneme discrimination and on the "Token Test." The results of our investigation seem to suggest that there are two types of anomia, caused by the impairment of two different sets of mechanisms. In "purely expressive anomia" the locus of defect seems to be near to the stage in which the selected lexical item is specified into the appropriate phonological form. In "anomia with lexical comprehension disturbances" the locus of defect seems to be much deeper within the lexicon, so that the semantic disorder affects both the expressive and the receptive levels in a roughly comparable manner.

Adult↗

Cognitive analysis of a case of pure dysgraphia.

An Italian patient with a pure dysgraphia who incorrectly spelled words and nonwords is described. The spelling errors made by the patient were not affected by lexical factors (e.g., frequency, form class) and were qualitatively the same for words and nonwords. The pattern of writing performance is discussed in relation to current models of writing and, specifically, in relation to the role of the Output Grapheme Buffer and Phoneme-Grapheme Conversion in writing.

Cerebrovascular Disorders↗

On the basis for the agrammatic's difficulty in producing main verbs.

Current theories of agrammatism do not provide a clear explanation for the co-occurrence of omission of grammatical markers and main verbs in this disorder. This study tested the hypothesis that the two symptom features have distinct underlying causes. Specifically, that the omission of main verbs in agrammatic speech is caused, at least in part, by a lexical (as opposed to a syntactic) deficit. Agrammatic and anomic aphasics and normal controls were given an object and action naming test. Agrammatic patients showed a marked impairment in naming actions in contrast to anomic aphasics and normal controls who named actions better than objects. The action naming impairment in agrammatic patients was interpreted as evidence for the lexical deficit hypothesis of verb omission in the speech of these patients and as a demonstration that agrammatism is a heterogeneous disorder that implicates damage to both lexical and syntactic mechanisms.

Adult↗

The production of morphological and lexical opposites in aphasia.

Four unselected groups of Broca's, Wernicke's, conduction, amnesic aphasic patients and a group of normal controls were asked to produce the best opposite of 60 adjectives. For half of the stimuli the expected opposite was morphologically related to the stimulus word (e.g. "formal"/"informal"), for the other half it could be obtained only by selecting a new base-form within the lexicon (e.g. "good"/"bad"). Following some neurolinguistic observations by Hécaen et al., it was predicted that amnesic patients should produce mainly morphological opposites, whereas conduction aphasics should produce mainly lexical antonyms. Results confirmed the predictions, since amnesic aphasics showed a prevalent impairment in the selection lexical opposites, whereas conduction aphasics showed a selective impairment in the production of morphological antonyms.

Anomia↗

Contrasting cases of Italian agrammatic aphasia without comprehension disorder.

Two patients with agrammatic speech and unimpaired comprehension are presented and contrasted. Case 1 had an infarction involving precentral gyrus, subjacent white matter, and posterior and superior aspects of the insula, largely sparing Broca's area. His speech was slow and dysarthric, consisting of short disconnected phrases with some omission of lexical verbs. Case 2 had an unusual transient aphasia of acute onset without hemiplegia; speech rate, articulation, and sentence length and complexity appeared normal. Both patients tended to omit function words and finite verb inflections, but Case 2 did so much more than did Case 1. Neither patient showed impairment in any other area of language performance. Tentatively, Case 2 is described as being more morphologically impaired but less syntactically impaired than Case 1, while neither has damage to a central language processor.

Adult↗

The processing of speech sounds in a patient with cortical auditory disorder.

A 56-yr old woman developed a cortical auditory disorder after two successive strokes involving the temporal lobes. Dichotic listening tests did not show a left car advantage with right ear suppression, as shown in other cases with similar disorders. Tasks exploring phonological analysis showed an impairment limited to the stop consonants. Within this framework, processing of feature place was selectively disturbed, while voicing was normally analysed. The possible role of psychoacoustic deficits in the pathogenesis of cortical auditory disorders is discussed. Some general considerations on cortical auditory disorders are also made.

Auditory Cortex↗

Contiguity versus similarity paraphasic substitutions in Broca's and in Wernicke's aphasia.

The present research was carried out to determine whether Jakobson's claim that Broca's aphasic patients emit chiefly semantic paraphasias of the similarity type, whereas Wernicke's aphasic patients produce mainly paraphasic substitutions of the contiguity type, can be supported by data gathered for clinical purposes under controlled conditions. Semantic paraphasias produced by 96 aphasic patients on a standard test of visual naming were taken into account. Three independent judges, blind to aphasia type, classified all responses retained as semantic substitutions into one of the following four categories: those having 1) a strong similarity, 2) a strong contiguity, 3) a mild similarity, and 4) a mild contiguity relation to the correct word. No relationship was found between type of semantic paraphasias and clinical form of aphasia. Furthermore, irrespective of the clinical form of aphasia, aphasics tend to give more similarity substitutions than contiguity substitutions.

Anomia↗

The relationship between type of naming error and semantic-lexical discrimination in aphasic patients.

When submitted to confrontation naming tasks, aphasic patients show different types of naming errors: phonetic, phonemic and verbal-semantic paraphasias, neologisms and anomia, but it is generally difficult to decide whether these errors are mainly due to a breakdown of the semantic systems or to post-lexical phonological disorders. In order to clarify this issue, 118 aphasic patients were given 3 tests of confrontation naming and 3 tests of semantic-lexical discrimination. Naming errors on confrontation were used to classify aphasic patients in various subgroups (according to the prevalence of a given type of naming error), whereas performances obtained on tests of semantic-lexical discrimination were taken as an index of disorganization of the semantic systems. The performances on semantic discrimination tests of patients showing a prevalence of phonetic, phonemic and verbal-semantic paraphasias, neologisms and anomia on confrontation naming tasks were compared. A very small number of semantic discrimination errors was obtained by patients showing a prevalence of phonetic and phonemic transformations on confrontation, whereas a much larger number of semantic discrimination errors was obtained by patients showing a prevalence of verbal-semantic paraphasias, neologisms and anomia.

Anomia↗

Neuropsychological correlates of localized cerebral lesions in non-aphasic brain-damaged patients.

A neuropsychological test battery made up of verbal, visual-spatial, and intelligence tests was administered to 82 right and 67 on-aphasic left brain-damaged patients with localized cerebral lesions, in order to draw impairment profiles of the various subgroups. Separate analyses were undertaken on patients with unilobar and multilobar lesions. As for hemisphere effects, LH patients performed worse than RH subjects on verbal tests, while the reverse was true for visual-spatial tasks. As for lobe effects, patients with frontal lobe damage fared worse than other subgroups on word fluency, independent of the side of the lesion. RH patients with multilobar posterior lesions were significantly more impaired than other RH subgroups on the test of Copying Drawings with Landmarks, probably owing to the detrimental effect of unilateral spatial neglect on tasks requiring an accurate visual-spatial analysis.

Brain Damage, Chronic↗

Influence of age, sex, literacy and pathologic lesion on incidence, severity and type of aphasia.

The influence of sex, age, educational level and pathologic lesion on incidence, severity and clinical form of aphasia was investigated in 390 right-handed, left brain-damaged patients. Sex and educational level were not related to any parameter. Etiology of lesion and age were related to both incidence and type of aphasia. Incidence of aphasia increased with age and was higher in patients with cerebrovascular accidents than in subjects with other types of brain lesions. Non-fluent forms of aphasia were more frequent in young patients suffering from acute cerebrovascular accidents, whereas anomia prevailed in neoplastic subjects and Wernicke's aphasia increased regularly in frequency with age. Some tentative explanations of these findings are discussed.

Adult↗

Semantic disorders of auditory language comprehension in right brain-damaged patients.

A test of auditory language comprehension was given to 110 right brain-damaged patients and to 94 normal controls in order to check if patients with lesions of the right (nondominant) hemisphere make a significantly higher number of semantic errors than normals. Confirmation of the hypothesis was obtained, but the relationship between semantic errors and lesion of the right hemisphere did not seem a simple and direct one. In fact, most of the lexical-semantic errors were due to associated variables (such as unilateral spatial agnosia and general mental deterioration) and not to the lesion of the right hemisphere per se. These data do not suggest a specific semantic capacity of the nondominant hemisphere but rather stress the fragility of the lexical-semantic organization at the cortical level.

Brain Damage, Chronic↗