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Biomedical subjects

G Micali

Publications and source records attributed to G Micali.

At least 55 records · Page 3Linked to original sources
PubMed1994

Lateral dermoid cyst of the tongue: case report.

The case of a young patient with a lingual dermoid cyst is presented. This case is unusual for the occurrence of the mass within the tongue, for its lateral localization, and for the association with other minor anomalies such as hypomelanotic areas, synophrys, hypertelorism and low-set and poorly structured ears. Bilateral broad, short fifth metacarpals with low-set fifth fingers of the hands were also present. A full clinical history, instrumental data, subsequent operative procedures and hystologic examination of the cyst, are described.

Abnormalities, Multiple↗
PubMed1994

Cephalic pyoderma gangrenosum (PG)-like lesions as a presenting sign of Wegener's granulomatosis.

BACKGROUND: Pyoderma gangrenosum (PG)-like lesions can be associated with Wegener's granulomatosis (WG); in rare instances, they could be the presenting sign of WG. The purpose of this study was to elucidate the relationship between these two disorders. METHODS: The clinical and histologic data from a case of WG with primary ulcerative lesions of the face were compared with five other cases previously reported in the literature. RESULTS: A predominance among young men was noted. In three patients the histology of the skin ulcerations was suggestive of WG, in the remaining three, including the case described, it was nonspecific. Two cases developed pulmonary WG after the skin lesions cleared, showing that the extent and severity of skin lesions do not necessarily correlate with the systemic disease. CONCLUSIONS: When the histology of the skin is nonspecific, the diagnosis of PG or PG-like lesions of the head and neck should not be considered definitive and the patients should be carefully monitored to rule out the possible presence of WG.

Adolescent↗
PubMed1994

Agminated lentiginosis: case report and review of the literature.

Agminated lentiginosis (AL) is characterized by numerous lentigines confined to a body segment, with a sharp demarcation at the midline. So far, only 13 cases have been reported in the literature. We report a 30-year-old woman with a multifocal AL. The cutaneous lesions first appeared at 5 years of age and gradually increased in number with time. Clinically, they appeared as numerous brown macules, ranging in size from 1 to 5 mm in diameter, in a peppered distribution over an area extending bilaterally on the neck, chin, and cheeks. On the trunk the lesions were localized to the left shoulder and breast, involving the axilla and upper part of the abdomen down to the umbilicus. Four café au lait macules ranging in diameter from 10 to 15 mm were present, with no evidence of neurofibromas. Histopathology of a macule showed the features of lentigo; in addition, groupings of melanocytes were observed at the dermoepidermal junction. The differential diagnosis of AL includes speckled lentiginous nevus and segmental neurofibromatosis.

Adult↗
PubMed1994

[Experience with cadexomer iodine (Iodosorb) in the treatment of skin ulcers].

Ten patients with cutaneous ulcers were treated with cadexomer iodine, powder and ointment. Cadexomer iodine was evaluated as reduction of ulcers area, pain, removal of pus and debris, exudate, stimulation to granulation, biohumoral tests and side effects. Cadexomer iodine was resulted, as ointment like as powder, a very efficacious drug for the treatment of cutaneous ulcers.

Adolescent↗
PubMed1993

The Italian contribution to plastic surgery.

The birth of what we now call plastic surgery dates to the fifteenth century, when the diffusion of nose amputation as a punishment was paralleled by the blossoming of surgical procedures for nose reconstruction. The relationship between the Eastern and the Western world fostered the spreading of the so-called Indian method, based on the use of a forehead flap. This technique was first introduced in Italy by the Branca family from Catania, Sicily. Eventually, a member of this family switched to a different approach to nose reconstruction using a cutaneous arm flap. This "Italian" method was followed and theorized by Tagliacozzi in Bologna. From the nineteenth century, distinguished surgeons like Sabattini, Tansini, Sterzi, Pieri, and more recently, Sanvenero Rosselli, with their pioneering work, substantially improved and helped develop plastic surgery in Italy as we know it today.

History, 15th Century↗
PubMed1993

Primary Merkel cell tumor: a clinical analysis of eight cases.

BACKGROUND: In recent years, an unusual biologic behavior of Merkel cell tumor (MCT) has been noted. In some patients, the tumor was indolent and well controlled by therapy, while in others it was lethal in a few months. Even though the majority of the reported cases are between these two biologic extremes, it seems evident that there is a high variability in the clinical course of the tumor. METHODS: A clinical analysis of eight cases of primary Merkel cell tumor was performed. All the patients presented with similar clinical features: age, tumor staging, duration of the disease, lack of complicating cutaneous or systemic diseases. On the basis of these common findings, which made this group quite homogeneous, our attempt was to identify other clinical signs that could correlate with the local recurrence and/or the onset of metastases. The outcome of our patients, in fact, was quite variable. RESULTS: The tumor size, the clinical aspect at presentation (single, multiple nodules, or plaque), the histologic pattern (all were of the trabecular type), and immunohistology did not correlate with the outcome. CONCLUSIONS: We report the rare occurrence of MCT in the perianal area, which suggests that it should be included in the differential diagnosis of perianal tumors, the very aggressive behavior of the tumor in two patients (death < 6 months from diagnosis), which confirms how the prognosis for MCT is unpredictable even if the diagnosis is established at an incipient stage and the tumor promptly removed.

Aged↗
PubMed1993

Segmental neurofibromatosis with only macular lesions.

A 16-year-old girl had a three-year history of many café au lait spots and freckles in a dermatomal distribution. The diagnosis of segmental neurofibromatosis (NF-5) was made on the basis of the clinical features, distribution of the lesions, and absence of systemic involvement. Only a few cases in the literature describe NF-5 with only macular lesions. An accurate clinical examination is important to identify this unusual presentation.

Adolescent↗
PubMed1993

Trichothiodystrophy: ultrastructural studies of two patients.

An 18-month-old and an 8-year-old girl had trichothiodystrophy (TTD). Microscopic observation of the hair under polarized light showed typical alternation of bright and dark bands; amino acid analysis of the hair demonstrated a marked reduction of cystine levels. Both patients had skin lesions consisting in the older child of diffuse follicular keratosis since birth, and in the younger of an ichthyosiform dermatitis on the lower legs that appeared at age 4 months. Ultrastructural studies of the skin showed striking similarities in both cases: perinuclear vacuoles with a unit membrane in the keratinocytes, and dispersed, irregularly arranged bundles of tonofilaments particularly at the desmosome junction. The origin of the vacuoles is unknown; the abnormalities of the tonofilaments could be explained on the basis of a generalized abnormality in sulfur-containing proteins, reflecting a disturbance in the synthesis of keratins. These electron microscopy findings could be considered as a peculiar feature of ichthyotic skin in patients with TTD.

Child↗