Biomedical subjects

G Mezei

Publications and source records attributed to G Mezei.

42 records · Page 3Linked to original sources

PubMed1983

Positive skin prick tests of immediate type in non-allergic children.

Prick tests with twenty different Beneard antigens were performed in 300 children aged 2-16 years, all having a negative individual and familial history for allergic disease. At least one positive result was obtained in 64% of the children and among the 6000 tests a total of 727 were positive. Of the positive tests 93% were + or ++, 7% were +++ or ++++. No relationship was found between age and the incidence of positive skin tests. Mild reactions against more than one antigen in the same individual were quite frequent, pronounced reactions (+++ or ++++) against more than one antigen were exceptional. The incidence of mild reactions was found to be independent of the gender; strong reactions occurred in girls twice as often as in boys. The highest incidence of positive reactions was observed with house-dust mite, pollens, hay and straw dust, and canine and feline hairs. The diagnostic value of mild positivity is slight but pronounced positivity, especially against more than one antigen, must carefully be considered and in any case followed by a bronchial provocation test.

Adolescent↗

PubMed1982

The prognosis of severe bronchial asthma in childhood on the basis of late reexaminations.

Four hundred and forty one patients treated for asthma between 1954 and 1978 were reexamined. Their age ranged from 15 to 36 years at the time of reexamination. To regard a case as severe, at least four factors out of the following six had to be present: 1. Attacks more frequent than one every week; 2. attacks lasting for more than one day; 3. six or more hospitalizations; 4. absence from school exceeding one month per school-year; 5. drop-out from school for at least one school-year; 6. steroid treatment for more than one week. 59 patients (13.3%) fulfilled the criteria. The sex ratio within the severe group was 1:1 although there was a male preponderance of all asthmatics. The recovery rate for the severe group was lower (40.6%) than for all patients (75.0%). Prognosis was less favourable in female than in male patients. In the severe group the disease appeared earlier, eczema during infancy occurred more frequently and allergic disorders had a higher incidence in the family than in the group as a whole. Chest deformities were observed in 48.7% of severe patients while its incidence was only 18.6% for all patients with asthma. Acetylcholine-induced bronchial hyperactivity was more frequent in the severe patients than in all patients irrespective of the degree of severity while the prevalence of exercise induced asthma showed no relationship to the degree of severity. Among the severe cases 31% failed to cope with a standardized physical load.

Adolescent↗

PubMed1981

[Asthma bronchiale and sport (author's transl)].

Follow-up studies were carried out in asthmatic children treated between 1954 and 1978 in the First Department of Pediatrics, Budapest, who have completed since then their 14th year of life. In 441 such children the sport achievements and the complaints after physical efforts have been taken into consideration. In 371 children tolerance tests with bicycle ergometer were done. It was found that among the recovered asthmatic children 48.9%, and among the nonrecovered 73.6% never have gone in for sport. The occurrence of bronchospasm due to bicycle-ergometer tolerance test (exercise induced asthma: EIA) corresponded to 19.5% among the healed patients and to 37.6% in the nonrecovered cases. In the authors' opinion, suitable persuasion could have induced a number of their former patients to go in for sport regularly. The authors refer the asthmatic patients to the possibility of physical culture. If EIA develops, medicaments are prescribed to these children, which enable them to go in for sport regularly.

Adolescent↗

PubMed1981

Effects of vasopressin analogues (DDAVP, DVDAVP) in the form of sublingual tablets in central diabetes insipidus.

The effects of 1-deamino-8-D-arginine vasopressin (DDAVP), 1-deamino-4-valin-8-D-arginine vasopressin (DVDAVP) and 8-arginine vasopressin (AVP) on water metabolism have been examined in 18 patients suffering from central diabetes insipidus. The hormone derivatives were sublingually administered. It was established that DDAVP and DVDAVP significantly reduced diuresis and increased urine osmolarity. DVDAVP was found to be more effective than DDAVP. AVP administered in equal doses had no significant effect on water metabolism. The duration of the action of sublingually administered DDAVP was 12 hrs; after dosing DVDAVP the effect lasted even 6 hrs. During one week of DDAVP administration, the accumulation of the drug was indicated by the gradual decrease of diuresis and the increase of the urine osmolarity. The sublingual administration of both DDAVP and DVDAVP tablets (3 X 30 micrograms/day) had an adequate therapeutic effect.

Adult↗

PubMed1975

Treatment of diabetes insipidus with 1-deamino-8-d-arginine vasopressin.

The effect on water metabolism of 1-deamino-8-D-arginine vasopressin and lysine vasopressin have been studied and compared in 20 vasopressin-sensitive and 2 ADH-resistant diabetes insipidus patients. In every case of ADH-sensitive diabetes insipidus, diuresis decreased and the urinary osmolality increased more markedly and for a longer time with the former than with the latter drug. Both drugs were ineffective in patients with ADH-resistant diabetes insipidus. Administration of 1-deamino-8-D-arginine vasopressin did not cause any side effect. It is concluded that 1-deamino-8-D-arginine vasopressin can successfully be employed in the treatment of ADH-sensitive diabetes insipidus.

Administration, Intranasal↗

PubMedDate not supplied

Household appliance use and residential exposure to 60-hz magnetic fields.

We characterized the distribution of exposure to magnetic fields (MFs) during daily activities and during household appliance use, and estimated the relative contribution of various activities and appliances to total daily exposure. One hundred sixty-two subjects provided information on their patterns of appliance use and wore personal monitors for 24 h to collect MF exposure data. Of total exposure, 27% accumulated while subjects were in bed; 41% while at home but not in bed; 9% at work; and 24% elsewhere. Less than 2% of the total MF exposure accumulated during the use of each of the eight individual appliances considered, except computers, during the use of which 9% of the total exposure accumulated. Of the time subjects spent at exposure levels higher than 2 microT, 8% accumulated while they were using microwave ovens, and 4% and 3% while using computers and electric stoves, respectively. Mean MF measurements tended to be lowest when subjects were in bed and highest at work and during the use of microwave ovens, coffee grinders, hair dryers, and electric shavers. Results from questionnaires on household appliance use in the past year were not useful in predicting the total mean exposure level and over-threshold exposures measured by 24-h personal monitors. Significant MF exposure accumulates at home, at work, and elsewhere; therefore, accurate exposure assessment needs to consider residential, occupational, and other sources together. Questionnaire-based information on appliance use has limited value in the assessment of average and over-threshold exposure to MFs.

Activities of Daily Living↗