Biomedical subjects
Publications and source records attributed to G Meyer.
Virus and Haapasalo report that the Blakemore and Sutton apparent spatial-frequency shift is not color specific. Also supposedly demonstrated is a McCollough effect that is not possible to spatial frequency. It is suggested that inadequate test procedures and a confusion between retinal and cortical adaptation negate these results.
Female R rats mated with an R male and inoculated in utero with polyoma virus after "fetectomy" developed tumors. These tumors originated in the uterus and were of fetal origin (visceral yolk sac). Histologically, they were hemangiomas or hemangiosarcomas. The latter were transplantable and grew in tissue culture. Infectious polyoma virus could not be isolated from the tumor cells kept as transplantable lines or cultured in vitro. However, the tumor cells were positive for the polyoma-specific surface antigen, polyoma tumor-specific transplantation antigen(s), and polyoma nuclear T antigen.
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Absorbed serum of a rabbit immunized with a suspension of cells of Hodgkins origin, allowed us to demonstrate a surface antigen on cells of Hodgkin origin. Where this antigen is situated in relation to those already described, notably in respect to the possible carcinoembryonic character, has yet to be determined.
We have previously shown the induction of agglutinability by concanavalin A by abortice infection of BHK 21 cells with polyoma virus. In this system, the maximal agglutination occurred simultaneously with the first mitosis. Using inhibitors of macromolecule synthesis in an amitotic system, we showed that this agglutinability was correlated with cell DNA synthesis.
Good immunoprotection was afforded by A9/SEWA somatic hybrid cells in the C3H mouse/C3H Py tumour system, confirming results previously obtained in the A.SW mouse/SEWA tumour system. However, in this study the immunogenicity decreased with increasing serial subculture of the hybrid line and concomitant chromosome loss.
By "camera-cinematography" of the heart, we mean an isotope method which permits detailed observation of cardiac mechanics without the use of a catheter. All that is necessary is an intravenous injection of 10 to 15 mCi 99mTc human serum albumen followed after ten minutes by a five to ten minute period of observation with a scintilation camera. At this time the isotope has become distributed in the blood. Variations in the precordial impulses correspond with intra-cardiac changes of blood volume during a cardiac cycle. Analysis of the R-wave provides adequate information of cyclical volume changes in limited portions of the heart. This is achieved by a monitor with a pseudo-3-dimensional display; contraction and relaxation of the myocardium can be shown for any chosen longitudinal or horizontal diameter of the heart. Our programme allows simultaneous presentation of the movement of any point on the myocardium as a time-activity curve. The method is recommended as an addition to chest radiography, heart screening or cardiac kymography before carrying out cardiac catheterisation.
A sarcoma was induced in an (A.CA X A.BY)F1 mouse. Two isoantigenic variants were selected by loss of one H-2 antigen. The tumor-associated transplantation antigens (TATA) of these variants were compared as to their specificities in (A.CA X A.BY)F1 mice. Both transplantation and indirect membrane immunfluorescence tests revealed that TATA of both variants did not cross-react. Thus selecting angainst different H-2 antigens also selected different TATA. Karyotype studies suggested that both variants originated from a unique clone.
A new surface antigen (S antigen) can be detected by immunofluorescence during the abortive transformation of hamster cells by polyoma virus. It was found that addition of interferon greatly reduces the percentage of cells positive for S antigen.
A syndrome of fever, lethargy, irritability and rash occurred in patients undergoing surgery, irradiation and chemotherapy for Wilms' tumor. The incidence, course and severity of these findings are described. Potential etiologic factors are analyzed and a hypothesis advanced.
Examinations were carried out on the occurrence of active virus, antigen and antibodies in the brain blood, or resp. of rabbits which were infected intracerebrally with the virus of Borna disease as a model of slow viruses. The techniques of the complement fixation and the immunofluorescence were used. Furthermore, an attempt was made to demonstrate interferon in the blood serum of the infected rabbits. Virulent Boran virus was observed two days after the infection and complement fixing antigen from the 10th day on. The immunofluorescence technique gave positive results in the nucleus of ganglion cells eight days after infection. The production of interferon in the sera could not be demonstrated. The brains tested 2, 4, 8, and 20 days after infection were also negative.
After whole-body irradiation with 200, 900 und 1500 R on mice Poly I:C induced serum interferon was decreased. 24 and 48 hours p.r. the interferon-synthesis in the three irradiated groups was considerably reduced. Increasing interferon-titer-yet lower than those of not irradiated controls - were found after Poly I:C application 3, 4 and 5 days p.r. in the groups irradiated with 200 and 900 R. In these two groups a relationship between irradiation-dose and interferon-synthesis was recognized.
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