Fine structure of trichocyst fibrils of the dinoflagellate Peridinum westii.
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Amino Acids↗
Biomedical subjects
G Messer
Publications and source records attributed to G Messer.
Organization of the AKR Qa region: structure of a divergent class I sequence, Q5k.
We established the organization of the AKR Qa region and determined the sequence of the Q4 and Q5 genes. Restriction mapping and genomic Southern blot analysis revealed that the AKR strain codes for only three H-2K homologous genes in this region. The AKR Q5 gene is not homologous to the Q5 gene of the C57BL strain, but is presumably allelic to the Q5 gene isolated from Balb/c. The organization and structure of the AKR Qa family is virtually identical to the Qa genes of the C3H mouse. The AKR Q5 gene, in contrast to other H-2K homologous Qa region genes, codes for a typical transmembrane region, and upon transfection into BHK cells, a 1.6 kb Q5 transcript is detected.
Amino Acid Sequence↗
Amyloidosis of Waldeyer's ring. A clinical and ultrastructural report.
Amyloidosis of the tonsil is a rare condition and amyloidosis of Waldeyer's ring has not been previously reported. The present study describes a case of amyloidosis of the tonsil, nasopharynx and base of tongue in a 35-year-old patient in otherwise good health and without clinical symptoms. The possibility of systemic amyloidosis was excluded by clinical examination and biopsy of rectal and buccal mucosae. Electron microscopy showed the presence of typical amyloid fibrils. Large masses of the fibrils were closely surrounded by cells which appeared to be phagocytic. The ultrastructure of these cells is described. This case is considered to be a unique type of organlimited amyloidosis of Waldeyer's ring.
Adult↗
Lupus erythematosus tumidus and chronic discoid lupus erythematosus in carriers of X-linked chronic granulomatous disease.
Two Caucasian carriers for chronic granulomatous disease (CGD) developed cutaneous lupus erythematosus (LE) with clinically and morphologically characteristic appearance for chronic discoid lupus erythematosus (DLE) and lupus erythematosus tumidus (LET). Direct immunofluorescent examinations and ANA titers were positive in both young women. No systemic involvement due to the ACR criteria was evident. Their sons suffered from X-linked cytochrome-b negative CGD. The diagnosis of CGD was based on measurement of oxidative burst activity by nitroblue tetrazolium (NBT) slide test and by flow cytometry using dihydrorhodamine 123 (DHR). The absence of cytochrome b558 in neutrophilic granulocytes was confirmed photometrically and by flow cytometry using the 7D5 monoclonal antibody against cytochrome b. We report for the first time the association of the photosensitive LE subtype LET and the X-linked CGD carrier state. Tissue damage by UV radiation and a reduced antimicrobial capacity may lead to recurrent immune stimulation and may together with genetic predisposition explain the occurrence of cutaneous LE in female carriers of CGD.
Adult↗