Accidental poisoning: pheniramine.
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Biomedical subjects
Publications and source records attributed to G Mendelson.
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A case of central anticholinergic syndrome after an overdose of orphenadrine citrate (Norflex), treated with tetrahydroaminacrine (THA, Tacrine) is presented. A possible mechanism for the syndrome is discussed in relation to other psychotic states, and the use of anticholinesterase agents in the treatment of toxic psychoses reviewed.
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Sudden headache, visual loss, and mental change developed in three patients with unsuspected pituitary tumours. In each case stereotaxic transnasal cannulation of the intrasellar mass demonstrated a liquid haematoma under moderate pressure which could be easily aspirated. Restoration of vision and relief from neurological disturbances was prompt. Radiation therapy was then administered to prevent recurrence.
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On the basis of recent research on the presence and function of an endogenous peptide with opiate-like activity present in the brain, and the developing understanding of the physiological mechanism of acupuncture analgesia, it is postulated that the analgesic effects of acupuncture are mediated through the action of this substance on the neural mechanism(s) of pain inhibition.
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