Modification of tRNA and its applicability for the assessment of prognosis, state of differentiation, and clonality in human leukemias and lymphomas.
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Humans↗
Biomedical subjects
G Meinhardt
Publications and source records attributed to G Meinhardt.
Screening for cervical cancer in Butha Buthe, Lesotho. A study of Papanicolaou (Pap) smears in a previously unscreened community over a one-year period.
The results of 2896 cervical smears taken from 2713 women at the outpatient department of Butha Buthe Government Hospital between January and December 1981 are reported. A high prevalence of mild and moderate dysplasia (18 per 1000) and of frank invasive carcinoma (5.2 per 1000) was found in this previously unscreened population. The rate of carcinoma-in-situ was 2.8 per 1000. The positive results are compared with other studies and analysed according to age and parity. The problems of treating cervical cancer in a Third World country with limited facilities are revealed and a cost/benefit analysis is attempted. Criteria for selecting a risk group are examined.
Adolescent↗
Treatment of trichomoniasis with a single oral dose of tinidazole ('Fasigyn').
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Administration, Oral↗
Evidence for cell adhesion-mediated drug resistance of multiple myeloma cells in vivo.
BACKGROUND/AIMS: Multiple myeloma is an incurable disease and patients eventually die of disease progression due to drug resistance. VLA-4 (very late antigen 4), VCAM (vascular adhesion molecule), LFA-1 (leukocyte function-associated antigen 1), and ICAM-1 (intercellular adhesion molecule 1)-mediated adhesion of myeloma cells to bone marrow stromal cells induces primary multidrug resistance in vitro. Based on these preclinical data we hypothesized that myeloma cells with strong adhesion - due to strong expression of adhesion molecules on the cell surface - are selected by chemotherapy in patients. To prove this hypothesis we determined the expression levels of adhesion molecules in 31 multiple myeloma patients by flow cytometry. METHODS: A 3-color stain with CD38, CD138 and antibodies against VLA-4, ICAM-1, LFA-1, and VCAM was performed. The patients were either at diagnosis (chemo-naive; n=17) or at relapse (pre-treated; n=15). Furthermore, the response to the next chemotherapy of chemo-naive patients was correlated with the expression levels of adhesion molecules. RESULTS: ICAM-1, VLA-4, and VCAM expression was higher in pre-treated patients than in chemo-naive patients and the expression levels increased with the number of chemotherapy regimens. Primarily multidrug-resistant patients had significantly higher expression levels of VLA-4 and ICAM-1 than responders. CONCLUSION: This study suggests that multiple myeloma cells expressing high levels of VLA-4 and ICAM-1 are drug resistant and that such a subpopulation of cells is selected by chemotherapy.
ADP-ribosyl Cyclase 1↗