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Biomedical subjects

G Mazzoni

Publications and source records attributed to G Mazzoni.

At least 73 records · Page 4Linked to original sources
PubMed1993

[The impact of technology on the diagnosis and treatment of pancreatic carcinoma].

Between 1960 and 1989, 207 patients with cancer of the head of the pancreas were diagnosed in the 1st Surgical Department of the University of Rome "La Sapienza". While in the first period (1960-'74) diagnosis was performed on the basis of clinical signs and traditional radiological findings, imaging and endoscopy became progressively the main diagnostic tools in the second one (1975-'89). The authors analyse how the different diagnostic approach has influenced the therapeutical outcome. Earlier diagnosis, increased resectability, proper surgical indication, decreased morbidity and mortality, improvement of survival are the achieved results.

Carcinoma↗
PubMed1993

The impact of ultrasonography on the prognosis of pancreatic cancer.

The authors review 207 consecutive patients admitted for pancreatic cancer from 1960 to 1989 to the 1st Department of Surgery of the University of Rome "La Sapienza", in order to ascertain whether ultrasonography contributes to achieving the ideal goal of early diagnoses. The results achieved show a higher number of early diagnoses (< 1 month from first symptoms) performed by means of US, and a concurrent increase of cases amenable to radical surgery during the period 1975-1989, and basically from 1985 to 1989. Diagnostic imaging, namely US, is therefore deemed to provide earlier diagnoses and higher rates of pancreatic resectability.

Female↗
PubMed1992

Indium-labeled presensitized T cells for diagnosis of graft rejection.

The aim of this experiment was to test a safe, noninvasive method for necessary, accurate diagnosis of early allograft rejection. Heart-lung allograft was performed heterotopically using Brown Norway (BN) rats as the donor and Lewis (LEW) rats as the recipient. T cell suspensions were prepared from lymphnodes of specifically sensitized LEW rats that had acutely rejected full-thickness BN skin graft. Cell count was adjusted 50 x 10(6) cells/ml. The suspension was incubated in vitro with 111I oxide (1 m Ci-ml). An aliquot of labeled cell suspension containing 40 x 10(6) cells and a total radioactivity of 200 mCi was administered intravenously to each animal 3 and 6 days after heart-lung transplant. The traffic of T cells was followed in vivo and in isolated organs under large field view gamma camera. The gamma camera revealed radioactivity on the graft starting Postoperative Day 5 when the heart was actively beating; no radioactivity was revealed at the site of the isografted organs. The histology showed mild to moderate cellular infiltration parallel to the grade of radioimaging intensity. The injection of indium-labeled presensitized T cells was able to detect the rejection process in an early phase when there are no clinical symptoms of rejection and/or the rejection cascade can be reversed. These results suggest that a similar method can be used in human organ transplantation for early diagnosis of rejection.

Animals↗
PubMed1990

Do memorability ratings affect study-time allocation?

This research addresses the relation between predicting future memory performance (judgment of learning, or JOL) and subsequent self-paced study-time allocation. The results of three experiments support the main hypotheses: (1) recall increases with increasing JOL, (2) restudy increases JOL accuracy, and (3) study time is related to JOL. This last relation depends on the length of initial presentation time of the items. When the initial exposure trials were short, the most restudy time was allocated to the items judged hard to recall, but when the initial exposure times were long, the most restudy time was allocated to the uncertain items. Items studied longer were recalled equally well (Experiments 1 and 3) or to a lesser extent (Experiment 2) than items studied for a shorter time. It is hypothesized that during study time, subjects refine their JOLs for the items initially less well discriminated.

Adult↗
PubMed1987

Nonfamilial intestinal polyposis and brain tumor in a 5-year-old girl.

A 5-year-old girl with glioblastoma multiforme and simultaneous adenocarcinoma in one of multiple colonic polyps is the youngest reported case of Turcot's syndrome. A literature survey and a classification based on family pedigree and pattern of inheritance are proposed.

Adenocarcinoma↗
PubMed1986

Reversibility of graft rejection following a short cyclosporin-A administration 5 days after grafting.

The aim of this research was to investigate whether cyclosporin-A (Cy-A) could exert its action on graft rejection in progress. For this purpose, heart-lung grafting was performed in a strong histoincompatible combination of rats (BN/LEW). In one group of animals, Cy-A was administered at the dose of 15 mg/kg daily for 10 days starting on the 5th day after grafting. In a control group only olive oil was administered. Five of six animals treated with Cy-A showed a graft survival over 4 weeks and in two cases it was over 2 months when they were killed.

Animals↗
PubMed1985

[Esophageal atresia associated with a subglottal stenosis. Apropos of a case].

The authors report a case of a 3 kg newborn with oesophageal atresia and congenital subglottic stenosis. The literature is reviewed and the management of our case reported. As in many cases the subglottic stenosis outgrows within a year of age, though tracheostomy is not justified even if general anesthesia is needed in case of major surgery.

Esophageal Atresia↗
PubMed1984

Immunological status in heroin addicts: effects of methadone maintenance treatment.

In opiate addicts specific and unspecific immune responses were examined, before and after methadone treatment. Anomalous immune responses were characterized by compromised cellular immunity (functional deficits of polymorphonuclear leukocytes and T-lymphocytes) in association with efficient production of antibodies. After methadone treatment an elevation of leukocyte functions was noted. The presence of elevated titres of circulating immune complexes observed in all the patients tested could bring about a functional exhaustion of neutrophils. The defects of cellular immunity can be considered important risk factors in the pathogenesis of infectious diseases in addicts.

Adolescent↗
PubMed1979

Growth-stimulating factor in regenerating canine liver.

Extracts from dog livers which had been regenerating for 24, 48, and 72 h after hepatectomy were infused for 6 h into the left portal vein of animals which had fresh portacaval shunts (Eck fistula) and which were killed 2 and 3 days later. The brief exposure to the 48-h and especially the 72-h regenerating liver extracts induced a delayed proliferative response predominantly in the left liver lobes, with a slight spillover effect to the right liver lobes but none to the kidney. The response reached its peak 3 days later. In the left but not the right liver lobes, both the 48-h and the 72-h regenerating liver extract reversed the atrophy ordinarily caused by Eck fistula in 3 days and partly prevented the ultrastructural hepatocyte deterioration characteristic of Eck fistula. The active liver extracts apparently contained a growth-control factor or factors which is (are) not insulin or glucagon.

Animals↗