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Biomedical subjects

G Martinotti

Publications and source records attributed to G Martinotti.

29 records · Page 2Linked to original sources
PubMedDate not supplied

[Chronic exposure to styrene and psychiatric symptomatology: a case-control descriptive study].

BACKGROUND: Although the acute psychiatric consequences exerted by Styrene and other aromatic hydrocarbons are abundantly described, the effects produced by a low-dosages chronic exposure are not known, in spite of the wide employment in the field of industrial production. The aim of this study is to evaluate the psychiatric symptoms in a group of subjects exposed to styrene in comparison with a control group, not exposed to the substance. SUBJECTS AND METHODS: Twenty two qualified workers, divided into 11 subjects in charge of welding and resin tapping exposed to styrene, and 11 not exposed to neurotoxic substances, were evaluated through the Symptom Check List Revised (SCL-90-R), a scale for the global self-evaluation of psychiatric symptomatology. RESULTS: The statistical tests, herein utilized, showed a significant prevalence for the dimensions somatization and psychoticism in the exposed subjects to styrene as compared to the non-exposed subjects. CONCLUSIONS: The results of this study, although limited by the paucity of the sample, emphasize the importance of an early diagnosis and evaluation of the clinical predictors in subjects exposed to styrene. The relatively low concentration levels of styrene in the working area of the subjects exposed underlines the opportunity to arrange preventive evaluation strategies for a prompt intervention in those cases with a clear syndromic presentation.

Adult↗
PubMedDate not supplied

Expression of the hybrid P210 bcr/abl protein in Philadelphia chromosome positive B-lymphoid cell lines.

An altered c-abl protein (P210) bearing increased tyrosine kinase activity represents the product of the hybrid bcr/c-abl gene arising as a consequence of the Philadelphia (Ph1) chromosome translocation, the consistent cytogenetic abnormality of chronic myelogenous leukemia (CML). Although the chronic phase of this disease is substantially characterized by a marked proliferation of myeloid cells, the Ph1 translocation occurs in an early multipotent stem cell, giving rise to both myeloid and lymphoid cell lineages. Here we show that P210 bcr/abl protein expression varies greatly in different Ph1 chromosome positive B-lymphoid cell lines obtained from Epstein-Barr virus-transformed lymphocytes of a CML patient in the chronic phase. In addition Ph1 positive and Ph1 negative lymphoid cell lines obtained from the same patient were tested for a number of biological properties including the immunophenotype, the capacity to grow in soft agar and possible tumorigenicity in nude mice. No differences were found.

Animals↗
PubMedDate not supplied

[Oral immunization of human adult volunteers using a trivalent coli-vaccine].

Oral vaccination of 19 human adult volunteers with a killed trivalent E. coli vaccine induced an antibody response detectable either in sera and feces. Production of specific IgA immunoglobulins in the intestine was also observed. Antibody titres reached the highest levels 5-10 days after vaccination and were still detectable in the majority of volunteers about 2 months later.

Administration, Oral↗