Biomedical subjects
Publications and source records attributed to G Martines.
Rabbits treated with therapeutical dosages of five widely prescribed drug (indomethacin, isoniazid, lorazepam, tolbutamide, clofibrate) show ultrastructural changes within live cells which are inhibited by concomitant administration of silymarin.
An experimental model which, unlike classical animal pharmacology models, stresses behaviour not of the organ or organism as a whole but of the cell ultrastructures of linked metabolic areas, is proposed. The new model would appear capable, within limits, of surmounting some of the main objections made when extrapolating animal data and referring it to humans. The application of the model to the analysis of the effects induced by administration of 7C3MT at the level of the liver cell metabolic areas described. Electron microscope observations show the substance has a positive influence on the functioning of structures engaged in synthesis and those occupied in breaking down drugs, thus supporting the hypothesis that the substance improves the liver's functional kinetics.
Percutaneous transluminal coronary angioplasty (PTCA) is an established technique in the management of patients with angina pectoris or acute myocardial infarction. One of the major problems related to PTCA is myocardial ischemia following balloon catheter occlusion of the coronary artery. A new device utilized in an attempt to counteract myocardial ischemia is the perfusion balloon catheter which allows passive transmission of pulsatile blood flow to the distal myocardial bed. Our purpose was to compare immediate results following traditional PTCA and autoperfusion balloon PTCA in two groups randomly assigned to receive one of the two treatments (total patients n. = 158). The results show that coronary angioplasty was successfully performed in 98.87% of patients treated with autoperfusion PTCA and in 97.10% of those treated with conventional PTCA. In the autoperfusion PTCA group we observed a lower incidence (statistically significant) of ST elevation and of minor complications. We conclude that autoperfusion balloon catheter angioplasty may be recommended for its immediate success rate with good patient tolerance and lower incidence of in-hospital complications.
It is well known that extracorporeal circulation (ECC) may determine an impaired renal function. The aim of our study was to identify those patients who, on the basis of the presence of cardiovascular risk factors such as diabetes mellitus, hypertension and hyperlipidemia, show more evident signs of such dysfunction. The study was conducted on 333 male patients, aged > 49 years, with normal renal function, who underwent coronary artery by-pass surgery in extracorporeal circulation. The results show that, among the cardiovascular risk factors, hypertension has a major influence on renal function after performing extracorporeal circulation, particularly on glomerular filtration rate and, when associated to diabetes mellitus, renal dysfunction may persist until the 9th post-operative day.