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Biomedical subjects

G Mariotti

Publications and source records attributed to G Mariotti.

At least 73 records · Page 4Linked to original sources
PubMed1979

Interstitial deletion 13q syndromes: a report on two unrelated patients.

A partial monosomy 13 by interstitial deletion was found in the complement of two patients with mental retardation and mild dysmorphic features. Neither of the patients had a retinoblastoma, even though the second patient had a 13q14 deletion. The karyotype-phenotype correlation in the two patients suggests the need to reconsider the clinical profile of these rare chromosomal syndromes in a large series of subjects.

Adolescent↗
PubMed1979

Thallium-201 myocardial imaging in young asymptomatic subjects with "ischaemic" changes in exercise electrocardiogram.

In order to assess the significance of a positive electrocardiographic response to exercise test in 10 asymptomatic subjects with normal resting ECG, a myocardial perfusion scanning with Thallium-201 at rest and during exercise was performed. The following ECG tests were also performed on these subjects: forced hyperventilation, exercise test after nitroglycerin (TNG), exercise test after propranolol. Myocardial perfusion scans did not reveal any defect at rest nor during exercise. Hyperventilation determined abnormalities of ventricular repolarization in all subjects. TNG did not improve the response to exercise test and even decreased the ischemic threshold. After propranolol the electrocardiographic response to exercise became normal in 9 cases, while in 1 subject the ST depressions were impressively reduced. All subjects had a follow-up of 14 to 91 months. During this period none presented symptoms suggesting a coronary disease. This study suggests that combined evaluation of Thallium myocardial perfusion imaging during exercise and exercise ECG test after TNG is most useful in differentiating ischemic from nonischemic exercise ST depressions in asymptomatic population.

Adult↗
PubMed1979

[The diagnostic value of bloodless methods and follow-up in young asymptomatic subjects with positive exercise test (author's transl)].

Fifty asymptomatic subjects, aged 22 to 40, with normal resting ECG and "ischemic" ST depressions during exercise were followed for 44 +/- 18 months. Coronary events occurred only in two cases. Unexpectedly in 12 subjects the response to maximal exercise became normal. In 25 subjects forced hyperventilation, exercise test after nitroglycerin (TNG), and after propranolol (P) were performed. Hyperventilation determined abnormalities of ventricular recovery in all cases. TNG did not improve the response to exercise, as it does in coronary patients, and even significantly decreased the "ischemic threshold"; after P the exercise test became normal in 20 subjects, while in 5 the electrocardiographic ST depressions were markedly reduced. The responses to pharmacological tests after the follow-up period were similar to the first observation. In 8 subjects, in which exercise ST depressions were particularly impressive, Tallium 201 myocardial scanning at rest and during exercise was performed. Myocardial perfusion imaging did not reveal any defect, thus confirming the non-ischemic nature of the ECG abnormalities. Our results confirm the low predictive accuracy (4%) of a positive stress test in a young asymptomatic population and suggest that, among non-invasive methods, exercise response after TNG is usefull in recognizing the "false positive" tests.

Adult↗
PubMed1979

[P wave analysis for the electrocardiographic diagnosis of left ventricular hypertrophy. A study of a population with arterial hypertension (author's transl)].

The electrocardiogram of 100 normal subjects and 216 patients with arterial hypertension in different stages have been analysed. P wave especially has been taken into consideration: it is often abnormal in the presence of left ventricular hypertrophy (LVI). The point-score system elaborated by Romhilt and Estes allows, if only QRS-T is considered, to diagnose LVI in 32 of the hypertensive patients (15%) and in 41 cases (19%) if the increase of P wave terminal forces is emphasized. Nevertheless this P wave characteristic does not appear more useful than others (axis less than or equal to 40 degrees; duration greater than or equal to 0.12 sec; presence of notch). The best results are achieved by considering the coexistence of two or more abnormalities of the P wave. Thus LVI is diagnosed in 52 (24%) of our cases, without false positive.

Adult↗
PubMed1978

Placebo effect in the treatment of angina pectoris.

The interference of placebo effect in the treatment of angina pectoris has been studied in a group of patients with stable angina pectoris, selected on the basis of normal electrocardiogram at rest and a pathologic ergometric electrocardiographic test. It was found that the patients could be divided, according to the results of the exercise test, into two groups: placebo responders and place-bo-non-responders. The anti-anginal effect of beta-blocking agents has been clearly demonstrated only in the placebo-non-responders group. No statistically significant effect of beta-blocking agents was observed in the placebo-responders group. This result shows that it is necessary, in double blind trials, at first to separate placebo-responders from placebo-non responders. Otherwise the correct evaluation of a drug can be modified by the placebo-responders group.

Adult↗
PubMed1978

Antianginal and haemodynamic effects of a new beta-blocking agent, SD 1601.

Seventeen patients suffering from angina pectoris were submitted to bicycle ergometer test until an ST ischemic segment of typical pain occurred. Before and during the effort the ECG was recorded: before and after the exercise, the systolic intervals were calculated and arterial pressure measured. The T.P. index, namely the product of systolic arterial pressure by the heart rate and ejection time was calculated. The recordings and the effort test were repeated 5 min after treatment with the beta-blocking drug 1-(o-methoxyphenoxy)-3-isopropylamino-2-propanol hydrochloride (SD 1601). After treatment with the blocker, patients were able to prolong the duration of exercise or perform a higher mean total external work. SD 1601 significantly diminished O2 myocardial consumption at rest, expressed as T.P. During physical exercise, work and thus O2 consumption rise; given equal external work, SD 1601 rduces significantly O2 consumption. Acutely given, SD 1601 did not affect systolic intervals nor did it exert any negative inotropic effect.

Adrenergic beta-Antagonists↗
PubMed1976

Treatment of acrodermatitis enteropathica with zinc sulphate. Rerport of 3 cases.

The therapeutic effect of orally administered zinc in 3 patients affected with Acrodermatitis enteropathica is reported. Single daily doses of zinc resulted in rapid improvement of the general condition of these patients and in clinical remission within a week. Serum, urine and hair zinc levels as well as alkaline phosphatase, which were very low before treatment, returned to normal after therapy. This brief report confirms the efficacy of oral zinc in the treatment of Acrodermatitis enteropathica.

Acrodermatitis↗
PubMed1975

Latent myocardial contractile impairment in patients with angina pectoris.

Intravenous injection of Angiotensin II gives rise to a rapid and transient increase of the afterload of the left ventricle (increased peripheral resistances). In this haemodynamic setting the functional behaviour of the left ventricle, through indirect parameters such as systolic time intervals, was compared in 14 patients with angina and in 15 normal control subjects. As regards blood pressure and heart rate a similar behaviour was registered in the two groups in basal conditions; directly after the intravenous injection of Angiotensin II changes suggesting impairment of left ventricular function failure have been obsered in patients with angina pectoris.

Adolescent↗