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Biomedical subjects

G Marinone

Publications and source records attributed to G Marinone.

At least 37 records · Page 2Linked to original sources
PubMed1978

[ Long-term evaluation of the effect of a chemotherapy protocol using vincristine, adriamycin, procarbazine and prednisone (VAPP) on advanced Hodgkin's disease].

A chemotherapeutic combination associating vincristine, adriamycin, procarbazine and prednisone (VAPP) was evaluated in Hodgkin's disease. Subjects were either far advanced cases or relapsing after MOPP and/or radiation therapy. 50 cases were evaluable. After 6 months of treatment 80% of the cases achieved a complete remission. After 30 months 87% of the patients still survive and 60% were still in complete remission. The good tolerance of this chemotherapeutic combination and the results described above, suggest that VAPP may be useful in all cases when MOPP is not well tolerated or is not active.

Adolescent↗
PubMed1976

Normal and pathological respiratory sounds analyzed by means of a new phonopneumographic apparatus.

A technique and an original apparatus for recording and displaying the sound levels emitted by human lungs during respiratory movements are described. By means of it a graphic recording of chest acoustics can be obtained. An analysis of the phonopneumographic findings shows clear differences between normal pathological readings, both in the level of the sounds and in their frequency content. Evidence is given of cases in which the physician can directly recognize the presence of special diseases. Beside this, FPGraphic representations are also useful for retaining evidence of findings which cannot be recorded by other methods, and for checking the natural evolution of a disease or its response to clinical treatments.

Humans↗
PubMed1975

[Current problems in therapy of evolutive malignant granuloma. Our experience with a new scheme of polychemotherapy].

Treatment of advanced Hodgkin's disease by associating vincristine, adriblastine, prednisone and procarbazine is compared with other widely employed protocols. Most subjects in the series had already received one or more drugs and had relapsed. In spite of this, 60% were still in complete remission one year after the administration of 6 courses of the new association. An account is given of maintenance therapy in Hodgkin's disease once remission is obtained, and the problems thus raised are illustrated.

Antineoplastic Agents↗
PubMedDate not supplied

Incidence and clinicopathological heterogeneity of HIV-related non-Hodgkin's lymphoma.

The characteristics of 14 HIV-seropositive patients with NHL consecutively observed between 1984 and 1988 at our Institution are described. Patients belonged to a known population of 1242 HIV-seropositive individuals in whom the incidence of NHL was 1.13%, significantly higher than in age-matched controls (P less than .0001). Within this population, a previous diagnosis of ARC or AIDS, but not of LAS, was the only significant risk factor for the development of NHL (P less than .0001). According to the status of HIV infection at the time of NHL diagnosis, two groups of patients could be clearly identified with different clinicopathological features and prognosis. In fact, NHL developing in 7 patients previously affected by ARC or AIDS, presented as localized, extranodal disease, predominantly in the CNS; large cell histology, peripheral blood cytopenia, severe immunodeficiency and poor prognosis further distinguished this subgroup. Conversely, NHL developing in 7 patients with either asymptomatic HIV-seropositivity or LAS, more often presented as disseminated disease both in nodal and extranodal sites, with Burkitt's-type histology. Cytopenia was uncommon and immunodeficiency was significantly less severe. In this subgroup complete remission (CR) was achieved with aggressive treatment in 6 of 7 patients. No relapses occurred but two opportunistic infection-related deaths were observed. Four patients are alive 6-34 months after CR, two of whom show newly developed opportunistic infections.

Adult↗
PubMedDate not supplied

Acute cholestatic Hodgkin's lymphoma: an unusual clinical picture.

Hodgkin's lymphoma (HL) simulating acute cholestatic hepatitis is a very unusual clinical picture. Massive liver infiltration with conspicuous acute cholestatic symptoms, in fact, suggests more aggressive systemic diseases such as non Hodgkin's lymphomas or acute leukemias. Nevertheless, we observed two cases of mixed cellularity H.L. showing all the symptoms of acute cholestatic hepatitis, without systemic lymph nodes involvement. Diagnosis was achieved by liver biopsy. Hepatic histology showed extensive portal and periportal Hodgkin's infiltrations, loss of periportal liver cells and variable damage to small bile ducts. In both cases bone marrow biopsy showed granulomatous infiltrations. Liver failure appeared to be the most frequent terminal complication of cholestatic H.L. The course of the disease was rapid, and cytostatic therapy scarcely effective. In our opinion, the cholestatic variety of H.L. should be considered in the differential diagnosis of all cases of acute or chronic cholestatic hepatitis, irrespectively of the presence of systemic lymph nodes enlargement.

Acute Disease↗