Search PubMed⌕ Search

Biomedical subjects

G Marini

Publications and source records attributed to G Marini.

At least 109 records · Page 6Linked to original sources
PubMed1983

[Pharmacokinetics of amiodarone in one case of acute oral intoxication].

A wealth of data about the clinical use and the therapeutic efficacy of chronic treatment with amiodarone has been reported, while the acute effects of this agent are less known. In one case of acute oral intoxication with 8 g of amiodarone for suicidal purposes, we have investigated the pharmacokinetics of amiodarone, the thyroid function and the variations of some clinical parameters, such as heart rate and QT interval. Other possible side-effects have been looked for. We have not observed substantial pharmacokinetic differences between our case and studies carried out after chronic oral or intravenous administration. Unlike chronic administration, the acute oral load was not followed by the appearance of toxic effects. The absence of toxic phenomena can be explained by the poor bioavailability of amiodarone, which is known to require long periods for a complete distribution to the tissues and target organs.

Adult↗
PubMed1981

[Cerebral lesions in attacks of transient ischemia. Results of clinical studies of microcirculation with perfusion brain scintigraphy (PBS)].

35 patients with supratentorial ischemic lesions were studied with the Perfusion Brain Scanning; 20 of them suffered for TIAs while 15 had Completed Strokes. In all cases a damage of the arteriolar-capillar bed were demonstrated. These findings favour the thesis that the focal supratentorial ischemic attacks are related to an irreversible lesion of the brain microcircle. The very high sensitivity in the detection of the small cerebral lesions and the diagnostic value of the PBS are underlined.

Adult↗
PubMed1981

In vitro binding of 125I-HCG to the rat ovary from birth to puberty.

Neither homogenates nor frozen ovarian sections of rats aged 1, 5 and 7 days demonstrated specific binding of 125I-HCG. However, from day 10 to day 35, the homogenates could bind specifically, with an equilibrium association constant in the range of 0.9-2.7 x 10(10) M-1. The binding capacity increased from 5.8 fmol/mg tissue at day 10 to 15.7 fmol/mg tissue at day 35. As revealed by autoradiograpy, the frozen ovarian sections from 10-day-old rats showed 125I-HCG binding localized over the interstitial and thecal tissues and, in the older age groups, also in the granulosa cells of follicles larger than 500 micrometers in diameter. These results indicate that LH/HCG receptors appear in the rat ovary at the beginning of the second postnatal week, and that the interstitial cells are the main site of action of LH before puberty.

Animals↗
PubMed1981

Circulating immune complexes in human acute leukaemia.

Circulating immune complexes (CIC) in the sera of 60 newly diagnosed leukaemic patients were investigated by two methods, 125I-C1q binding test (C1q-BA) and conglutinin binding assay (KgB-SP). Positivity percentages were respectively 20.0% (C1q-BA) and 28.3% (KgB-SP). The small overlap between the results of the two methods suggests the occurrence of different types of CIC. The presence of CIC was found to be related only to clinical haemorrhage and thrombocytopenia; it did not prove to affect the prognosis and the survival of leukaemic patient.

Acute Disease↗
PubMed1981

A horseradish peroxidase study of afferent projections to nucleus reticularis thalami in the cat.

Afferent projections from both the reticular formation and the thalamic relay nuclei to nucleus reticularis thalami (R) were studied using the HRP technique. Injections were performed in different regions of the nucleus. Numerous labelled cells were found ipsilaterally in i) the lateral geniculate nucleus (GL) following HRP injections in dorsolateral regions of R and in ii) the ventrobasal complex (VB) following HRP injections in the ventral regions. No labelling of brain stem reticular structures was ever found. These results provide evidence for a direct projections from the VB and GL nuclei to R. The functional meaning of these data is discussed in relation with previous anatomical and neurophysiological findings. The hypothesis of a significant role of R in feedback circuits modulating sensory information seems to be supported.

Afferent Pathways↗
PubMed1979

[Histochemical demonstration of tetrahydrofolate dehydrogenase in human bone marrow: apparent enzymatic induction after administration of folic acid antagonists].

Folate antagonists interfere to a varying extent with the histochemical demonstration of tetrahydrofolate dehydrogenase. Some aspects of this interaction are investigated in normal hemopoietic cells of patients following antitumor treatment with methotrexate. In this situation the histochemically detectable activity of tetrahydrofolate dehydrogenase exceeds the control levels (apparent enzymatic induction). A protection of the enzyme-metabolite complex from degradation and diffusion might be effective for the changes in reaction intensity.

Bone Marrow↗
PubMed1979

A histochemical study of the binding of 125I-HCG to the rat ovary throughout the estrous cycle.

Changes in the distribution of the in vitro uptake of 125I-HCG by the ovaries of adult rats were examined histochemically throughout the estrous cycle. Only in follicles wider than 500 micrometer, occurring mainly at diestrus and proestrus, could granulosa cells bind the labelled hormone. The labelling increased with follicular size and decreased in intensity from the peripheral granulosa cells inwards. No uptake occurred in the oocytes, in the cells of the cumulus oophorus nor in the granulosa cells of the atretic follicles. The binding capacity of the newly-formed corpora lutea of estrus was less than that of preovulatory follicles. The uptake of 125I-HCG by corpora lutea during the first cycle reached its maximum at diestrus but fell sharply by proestrus. The uptake was patchy in the corpora lutea of the second cycle and not significant in the older ones. The uptake of 125I-HCG by thecae increased with follicular size and was greater in the thecae of atretic follicles than in the thecae of growing follicles of like size. There was a greater uptake in the last formed interstitial tissue than there was in older tissue. At proestrus, the uptake of 125I-HCG was unaffected by the LH surge at 18.00 h but had decreased slightly at 24.00 h. The implications of these data in relation to the regulation of receptor sites, is discussed.

Animals↗
PubMed1979

Carcinoma associated with lipomeningocele: case report.

We report the case of a 41-year-old man with an epidermoid carcinoma that had developed on a meningocele with a fistulous tract that chronically drained cerebrospinal fluid. After a review of the literature, we discuss the cause of this rare occurrence. We think that the recurrent discharge of spinal fluid (never complicated by meningitis) may have caused a chronic irritation of the tissues and then the delayed development of a carcinoma, which is similar to a case found in the literature. In our case there was a "flow" of carcinomatous cells along the fistula, which entered the meningocele, invading the subdural space as far as the peduncle. Our patient, who had a benign lesion (meningocele), came under neurosurgical care only after the lesion had degenerated. The malignant degeneration of such a benign lesion emphasizes the need for surgical treatment as soon as possible.

Adult↗