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Biomedical subjects

G Manigand

Publications and source records attributed to G Manigand.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Diffuse bone metastases revealing pleural mesothelioma. Case report].

A 76 year old man, presenting with symptoms of general malaise alone, had a marrow biopsy which showed and undifferentiated carcinoma. A subsequent autopsy revealed a multi-nodular pleural mesothelioma, which was not seen radiologically, presumably because of the small size of the nodule. There were bilateral adrenal metastases and diffuse bony metastases involving the marrow. An occupational contact with asbestos was retrospectively confirmed. It is rare that a pleural mesothelioma does not exhibit thoracic signs and very uncommon that bony metastases should give the diagnosis in such a tumour.

Aged↗
PubMed1984

[Yellow-nail syndrome. Review of the literature apropos of 2 cases associated with cancer].

Two cases of "yellow-nail syndrome" are reported: in the first, nail changes began eight months after the diagnosis of a breast cancer; in the second, yellow dystrophic nails were associated with hypertrophic osteoarthropathy due to pleuro-pulmonary metastatic lesions. Clinical features are described: characteristic nail changes, lymphoedema, pleural effusions, and, often bronchopulmonary infections and sinusitis. Various combinations are seen, and the time between the development of the different manifestations may vary from several months to many years. Among associated diseases, immunological changes and malignancy are emphasized. The pathogenesis remains obscure. Accurate part taken by lymphoedema, immunological changes, is unknown, and the relationships between "yellow-nail syndrome" and malignancy are still uncertain.

Aged↗
PubMed1983

[Inflammatory arthritis and osteoarthritis in palmoplantar pustulosis. Case report and review of the literature].

The case of a 46-year-old woman, who had pustulosis palmaris three years ago, and who has been experiencing inflammatory arthritis of the manubriosternal joint for two years with intermittent exacerbations, is reported. The negative bacteriologic investigations and the failure of antibiotic therapy have established that the condition is aseptic. Among patients with a history of palmo-plantar pustulosis, approximately 10% have aseptic inflammatory arthritis or osteitis, most commonly in the anterior chest wall. Other sites are the sacroiliac joints and the spine, where radiological features mimic ankylosing spondylitis, and peripheral joints. Laboratory anomalies are not specific, and HLA B27 antigen is not associated with this syndrome. The course of the arthritis, with exacerbations and remissions, is generally benign. The relationship of this syndrome to psoriatic arthritis is unclear. Non-steroidal antirheumatic drugs are the most effective agents.

Adult↗
PubMed1983

[Nail pigmentation during therapy with cyclophosphamide and doxorubicin].

Two patients under cytotoxic therapy developed pigmentation of their fingernails. The first, under doxorubicin and cyclophosphamide for lymphoma, had horizontal streaks, while the second, under cyclophosphamide for periarteritis nodosa, exhibited diffuse pigmentation. Nail pigmentation, which occurs after an interval of some weeks or months, varies from diffuse to horizontal or longitudinal streaks. Reversal of nail pigmentation some months after withdrawal of the drug is usual. Skin or mucous membrane pigmentation may coexist. The mechanism of pigmentation remains obscure. These changes are observed more frequently in black than in white patients. In some instances, they have been recorded in several members of the same family.

Aged↗
PubMed1983

[Esophageal fistulas in mediastinal tuberculous adenopathies in adults].

An adenopathy perforated into the esophagus in a thirty-two-year old woman from black Africa with mediastinal and abdominal tuberculous adenopathies. The fistula was disclosed upon endoscopic examination in the absence of esophageal symptoms. The characteristics of such fistulas are recalled: location in the middle third of the esophagus, inconspicuousness of symptoms, scarcity of complications among which digestive hemorrhage is the most significant, usually favorable course under medical management alone. The latency of fistulas between tuberculous adenopathies and the esophagus warrants routine fiberoptic endoscopy in patients with mediastinal tuberculous adenopathies.

Adult↗
PubMed1982

[Spontaneous hemarthrosis in adolescents and adults, excluding hemophilia].

The various etiologies of spontaneous hemarthrosis in adolescents and adults are reviewed: they include systemic diseases and local or regional disorders of the bones or joints. Among systemic diseases, the two main causes are coagulation disorders and hemoglobinopathies. Coagulation disorders may be either acquired (leukemia, thrombopenia, and hypoprothrombinemia induced by anticoagulant drugs with hemarthrosis being one of the major complications) or inherited (hemophilia which is not considered here, von Willebrand disease, and congenital thrombopathies). Hemoglobinopathies, particularly sickle-cell disease, are responsible for hemarthrosis in a few patients. Among local or regional disorders of the bones or joints, tumors such as hemangioma or synovial sarcoma are uncommon causes. Hemarthrosis is the main feature of pigmented villonodular synovitis. Hemarthrosis may occur in degenerative and metabolic diseases: while it is extremely rare in arthritis, it is frequently encountered in articular chondrocalcinosis which is the first diagnosis to consider when hemarthrosis occurs in an elderly patient. The search for an etiology, which is often difficult, should include a review of prior illnesses, a study of coagulation, and local clinical, radiological and biological investigations, with a study of the synovial fluid; in some instances, arthroscopy, synovial biopsy and even surgical exploration are required. Management includes rest, analgesics, antiinflammatory drugs and, above all, arthrocentesis which is essential for the prevention of articular damage and functional sequellae. Specific therapy is dependent on the etiology. In recurrent hemarthrosis, isotopic synoviorthesis may ensure lasting resolution of the effusion.

Adolescent↗
PubMed1982

[Sarcoidosis and hyperthyroidism (author's transl)].

The authors report the case of a 31-year-old man with thyrotoxicosis which occurred four months after the discontinuation of long-term corticosteroid therapy for sarcoidosis. Clinical and biological features of thyrotoxicosis were reversible when corticosteroid therapy was reinstated. A review of 27 cases from the literature provides the opportunity to recall the characteristic features of hyperthyroidism associated with sarcoidosis: female prevalence, usual presence of sarcoidosis at onset, secondary occurrence of hyperthyroidism, necessity for simultaneous treatment of both diseases, since corticosteroid therapy alone is infrequently sufficient.

Adult↗
PubMed1982

[Aortic dissection and Horton arteritis].

Aortic dissection in a 61-year-old woman treated symptomatically and with a fatal outcome within three months by extension to the arch of the aorta and its major vessels, and as a direct result of haemopericardium. The association with temporal arteritis, presenting before the aortic complication by prolonged headache with raised sedimentation rate and painful inflammation of both temporal arteries, was confirmed by histopathological examination of the aorta. This revealed giant cell arteritis independent of atheromatous lesions. The association of aortic dissection and temporal arteritis is very rare. Clinical and pathological examination of the smaller arteries and in particular the craniocephalic arteries is therefore justified in all cases of aortic dissection. When it affects the aorta, temporal arteritis may favor aortic dissection as a result of changes in the media.

Aortic Dissection↗
PubMed1981

[T lymphocytes functions in mercuric chloride-induced membranous glomerulonephritis in man. Evidence for a defect of presentation of the histocompatibility class II molecules at the cell surface (author's transl)].

Membranous glomerulonephritis (MGN) is one of the well documented manifestations of autoimmunity during chronic mercuric chloride (HgCl2) intoxication. We have carried out immunological investigation of the T cell functions in a patient presenting an HgC12-induced MGN. Circulating auto-antibodies and immune complexes were absent from the serum. Lymphocyte transformation with HgCl2 over a wide range of doses (10(-3) to 10(-8) M) was negative. E rosettes, mitogen reactivity, allogeneic reactivity evidenced by a one way mixed lymphocyte culture gave slightly diminished results. These findings contrasted with a severe impairment of the stimulative ability of lymphocytes. This defect might be related to the inability of D, DR products to be exposed at the cell surface and impeding the allogeneic recognition by foreign lymphocytes. This lymphocyte defect in the course of an HgC12 MGN in man would be correlated with lymphocyte abnormalities found in experimental HgC12-treated rats. The results of this study would favour the hypothesis of a direct role of HgC12 on lymphocyte rather than a direct action on glomerular basement membrane.

Adult↗
PubMed1981

[Glomerular nephropathies in hepatic cirrhosis (author's transl)].

Glomerular lesions were studied in 41 patients with hepatic cirrhosis (32 cases) or steatosis (9 cases) by optical microscopy (38 cases) and immunofluorescence (22 cases) examinations of biopsy samples. The most frequently observed lesion on optical microscopy was a glomerulosclerosis (16 cases), arteriolar lesions being present in 15 cases, two-thirds of which had associated glomerular lesions. Immunofluorescence revealed the presence of immunoglobulin deposits in 17 cases, these possessing two main characteristics: the prevalence of IgA (14 cases), alone or in association with other immunoglobulins; and the predilection for the mesangium alone, or in association with parietal deposits. The glomerular nephropathy in the cirrhotic patients was completely latent in 3 out of 4 cases, renal signs, when they existed, being of mild intensity. Renal lesion can occur in the absence of severe hepatopathy, particularly in the presence of steatosis. IgA deposits in the mesangium, a fundamental feature of hepatic glomerulopathy, can be related to the presence of IgA deposits in the liver sinusoids, suggesting the development of IgA deposits in several organs during these affections. Their pathogenesis is still obscure but two hypotheses have been suggested: an immune disease with deposits of circulating immune complexes in the kidney; a non-immune disease, IgA deposits being a secondary and not a primary feature.

Adult↗