[Acute hemorrhagic necrotizing forms of chronic recurring pancreatitis].
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Biomedical subjects
Publications and source records attributed to G Mangold.
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In 95 patients suffering blunt abdominal trauma the diagnostic validity of abdominal exploration, blood pressure, pulse rate, leukocyte count, and hemoglobin was compared with the results of peritoneal lavage for the detection of intra-abdominal bleeding. Classical clinical symptoms alone are not reliable in evaluation of the patient with abdominal trauma, especially if there are associated multiple injuries. Diagnostic peritoneal lavage has the highest accuracy (more than 95%) and an early diagnosis of intraperitoneal bleeding by widespread use of this method improves the prognosis in these patients.
22 out of 180 patients with chronic relapsing pancreatitis showed an acute hemorrhagic-necrotizing exacerbation. in 11 out of these there was an indication for operative management of the chronic pancreatitis before onset of the acute exacerbation. The clinical picture is similar to that of the acute hemorrhagic-necrotizing pancreatitis. The surgical procedure consisted in digital removal of necrotic tissue and left-sided resection. 13 out of the 22 patients survived.
The surgical therapy of chronic pancreatitis has been enriched by the progress of diagnostics in gastroenterology and radiology. This includes as well the definition of indication for surgery as the choice of the most suitable operative procedure. Thus today an individual surgery with regard to the morphological findings is possible by making allowance for the patients personality on the one hand and for the pathologic changes of the gland on the other. Long term follow-up studies of the last years have shown good results after pancreaticojejunostomies and particularly after pancreatic resections. In our twelve years-experience with chronic pancreatitis there is a preference for resection therapy too.
The postoperative blind-loop syndrome can occur after side-to-side, end-to side or by-pass anastomoses of the gut and presents clinically as malabsorption syndrome. Pathogenetically, stasis or slowing of the bowel movements will cause a rapid increase of pathogenic bacteria in the small intestine. Malabsorption is characterized by 3 symptoms: Loss of weight, anemia, steatorrhoea. The method of choice for therapy is to perform a new, end-to-end, anastomosis of the intestine in order to re-establish a physiological situation. During the last 6 years 14 patients with malabsorption syndromes of varying degrees were operated upon: 6 had pure small intestinal anastomoses, 7 anastomoses between the small and large intestine and 1 patient had a side-to-side sigmoidal anastomosis. In all patients the side-to-side or by-pass anastomoses could be reversed.
In 32 patients with acute pancreatitis, delayed operation was performed between 13 and 44 days after onset of the illness. The indications for the operation were development of a palpable mass together with clinical deterioation and other complications. In all patients we found a necrotizing pancreatitis and/or abscesses of the pancreas. The surgical procedure consisted of digital removal of necrotic tissue (sequestrotomy) and/or abscess incision in 20 patients, of left-sided resection in 11 patients and partial duodenopancreatectomy in 1 patient. Twenty-three patients survived, 9 died.
At the Surgical University Clinik of Mainz 53 patients with a pancreatic fistula have been observed in 12 years (1964-1975). Most frequently these fistulas occurred after operations for acute pancreatitis (20%), after exstirpation of insulinomas (20%) or after trauma (19%). In 44 cases an external and in 9 cases an internal fistula was seen. Pathogenetic differentiation in tryptic and non-tryptic fistulas allows some prognostic conclusions. So tryptic fistulas are often complicated by internal fistulas with preference for the colon and must be operated more often. In 15 patients the persisting pancreatic fistula has been treated operatively. In seven cases pancreatic resection and in 4 cases the resection of a part of the colon was necessary. Conservatively treated fistulas in most cases closed within 6 weeks.
Between 1973 and 1975, the "early" operation was carried out in 15 patients suffering from acute haemorrhagic-necrotizing pancreatitis to eliminate necrotic parts. Partially necrotizing pancreatitis was identified in 10 patients: 7 survived. All patients with total pancreatic necrosis died. Surgery consisted of digital removal of the necrosis (digitoclasia) and in left resection with adequate drainage. Patients with partially necrotizing acute pancreatitis can be saved by "early" surgery while in patients with total necrosis surgery must be undertaken even earlier, namely before fatal complications set in.
From 1964 to 1975 a total of 338 patients were operated on for pancreatic cancer. Duodenopancreatectomy was performed in 69 (20%), at a postoperative death rate of 16%. Second look operations proved to be worthwhile. Thus the resection rate after first operations elsewhere was 27%. Five patients lived for more than five and 19 for more than two years after operation. Since 1971 30 patients have survived so far after radiacal operation.
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In operative treatment of pancreatic pseudocysts by inner drainage there is a risk of massive gastrointestinal bleeding particularly following an anastomosis to the stomach. In 10 patients in whom cystogastrostomy or cystoduodenostomy had been performed elsewhere a second laparotomy was necessary because of acute bleeding. In one patient a cystadenoma of the pancreas had been anastomosed to the duodenum by mistake at the previous operation. The leak of obliteration of the cyst is suggested to be the most important factor in the pathophysiology of bleeding. Inner pseudocyst drainage in a disconnected small bowel loop therefore principally should be performed at the lowest point of the cyst. The indication for an inner cyst drainage, however, must be closely examined since simultaneous pathologic changes in the pancreas often justify a resection to remove the origin of the cyst and, further, averting the complications of an inadequate inner pancreatic cyst drainage.
Between 1973 and 1975, "early" operation with removal of necrotic tissue was performed on 15 patients with acute haemorrhagic-necrotizing pancreatitis. Partial necrotizing pancreatitis was found in ten patients, of whom seven survived. But all patients with total pancreatic necrosis died. Two early operations in patients with a necrotizing bout in the course of chronic recurrent pancreatitis were successful. The surgical procedure consisted of digital removal of necrotic tissue (greater than digitoclasia less than) and left-sided resection, combined with adequate drainage. Patients with acute, partial necrotizing pancreatitis can be saved by early operation, while those with total necrosis would require almost immediate surgical intervention, before the onset of lethal complications.
Two patients (33-year-old man and 24-year-old woman) with focal nodular hyperplasia of the liver were treated by surgery in 1973. This is a rare neoplasm of the liver which, according to past experience, is a benign one. The clinical signs and symptoms in the two patients were uncharacteristic, but on angiography there was marked tumour vascularization. Histologically the tumour is closely related to a hamartoma but its classification is diffucult because of the confused nomenclature.
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