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Biomedical subjects

G Manfredi

Publications and source records attributed to G Manfredi.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Atrophic zoniform nevus].

The first, in our knowledge, case of naevus atrophicus zoniforme in italian literature is here reported. A 13 year old girl had a thirteen years history of involved numerous depressed areas of skin of the right anterior region of the chest and of the right upper arm. The lesions were round, grey-bluish, smooth, depressed, completely asymptomatic. No inflammatory changes were noticed in affected patches nor in surrounding normal skin. The histologic changes were compatible with dermal atrophy: epidermis was quite normal; dermis war very thin; the thickness of hypodermis was increased. Some large nervous structures were visible within deep dermis. Histochemical changes mainly involved elastic fibers, whose thickness was considerably increased. The diagnosis of naevus atrophicus zoniforme is discussed, in comparison to other idiopathic atrophies. In conclusion, the main characters of naevus atrophicus zoniforme, according to literature data, are confirmed in our case: 1) congenital appearance 2) zoniforme distribution 3) dermal atrophy 4) thickening of elastic fibers 5) occurrence of large nervous structures in the dermis.

Adolescent↗
PubMed1981

Retinol binding protein in normal human skin and in cutaneous disorders.

Circulating vitamin A is transported by a carrier termed retinol binding protein (RBP). Autoradiography and immunofluorescence studies showed that, in normal human skin, RBP is confirmed exclusively to the dermis. Following oral vitamin A loading, a large increase in dermal RBP but only a very small rise of serum RBP was found. Serum RBP was slightly decreased in eczema patients and markedly decreased in patients with porphyria cutanea tarda. Values in other dermatoses, including psoriasis, were normal.

Adolescent↗
PubMed1980

[Retinoic acid and 5-FU mixture in the topical treatment of several skin diseases (author's transl)].

The need for safe and effective topical treatments is underlined by several clinical trials over the years treating miscellaneous dermatosis with many and heterologous drugs, sometimes on a simple empirical basis. In a recent study Robinson and Kligman claimed to have obtained satisfactory results treating several cases of actinic keratosis with an alternate regimen of retinoic acid and 5-FU. We wish to report an open-label pilot study using a simple and readily accessible combination of commercially formulated and available agents as 0,05% retinoic acid cream and 5% 5-FU cream over two groups of patients. Treatment consisted of bid application of sparing amounts of an equal parts combination of retinoic acid and 5-FU. The first group consisted of 7 patients affected by skin diseases associated with an altered epidermal keratinization (actinic keratosis, Darier's disease, seborrheic keratosis, phrynoderma and epidermodysplasia verruciformis). The patients were followed up for a period of 15 to 60 days and, as it might be expected, the results were quite good. The second group, on the contrary, consisted of 6 patients affected mainly by dermatosis involving the corium (LED, milium, colloid pseudomilium). The patients were followed up for the same period of time as the first group was, but the results were much less rewarding. Only a partial resolution of the process, which was followed soon after by a relapse, was noted. Finally we believe that this modified regimen of equal parts of retinoic acid and 5-FU has to be recommended in the topical treatment of the above mentioned dermatosis associated with an altered keratinization.

Drug Combinations↗
PubMed1979

Studies on dapsone induced haemolytic anaemia. I. Methaemoglobin production and G-6-PD activity in correlation with dapsone dosage.

The present study was undertaken on the hypothesis that methaemoglobin production and haemolytic anaemia following dapsone administration could be ascribed to an impairment of glucose-6-phosphate dehydrogenase-enzymatic activity. Analysis of the kinetic parameters of the G-6-PD (Vmax and KM) was performed in ten patients, normal with respect to G-6-PD, suffering from various dermatoses. It was concluded that haemolytic anaemia after dapsone therapy is not due to a functional impairment of the enzyme. The close relationship between dapsone dosage, methaemoglobin production and anaemia make reasonable the hypothesis that a toxic dapsone derivative (DDS-NHOH) could be responsible for the methaemoglobin formation and the haemolytic anaemia.

Anemia, Hemolytic↗
PubMed1979

In situ identification of mononuclear cells infiltrating cutaneous carcinoma: an immuno-histochemical study.

The present study was undertaken in order to investigate the exact nature of the cells surrounding cutaneous tumours. Formalin-fixed, paraffin-embedded sections were tested with a horse antihuman T lymphocyte serum and with IgG, IgA and IgM rabbit antihuman serum. All the sections were respectively treated with rabbit anti-horse or swine antirabbit peroxidase-labelled serum. The advantages offered by the immunoperoxidase technique are briefly discussed. T cells are in overwhelming proportion in comparison with IgG, IgA and IgM bearing cells. This seems a further demonstration that mononuclear infiltrate surrounding cutaneous carcinoma mainly represents a cell-mediated immune response.

Basal Cell Carcinoma↗
PubMedDate not supplied

Magnetic resonance measures in Alzheimer disease: their utility in early diagnosis and evaluating disease progression.

We sought to identify the most reliable magnetic resonance (MR) measures for the diagnosis and staging of Alzheimer disease (AD) in a clinical setting and to estimate, for different degrees of dementia, the rate of change of cerebral atrophy in certain regions of interest (ROIs). Forty-two probable AD patients and eight normal controls underwent MR brain scans, neurological examinations, and neuropsychological testing. We computed each subject's corpus callosum width, ventricular size, right and left temporal lobe areas, interuncal distance, and assessed the degree of cortical atrophy. We also estimated the rate of change for Information-Memory-Concentration Test scores and for temporal lobe areas and corpus callosum width. Measures of temporal lobe area and subjective evaluation of temporal lobe atrophy both served to distinguish controls from mild AD cases (p < 0.05), whereas only the latter differentiated moderate from severe patients (p < 0.05). The rate of change for temporal lobe areas remained constant over different AD stages, whereas those for corpus callosum width and for cognitive impairment were greater for severe cases (p < 0.05). Our findings imply that measurements of temporal lobe area and ratings of temporoparietal atrophy can be useful in the diagnosis and staging of AD and suggest that atrophy progressed at different rates in selected ROIs for various stages of AD severity.

Aged↗