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Biomedical subjects

G Mahrle

Publications and source records attributed to G Mahrle.

At least 109 records · Page 6Linked to original sources
PubMed1985

[Hereditary sclerodactyly and syndactyly].

A 61-year-old man is described with sclerodactyly of the hands and syndactyly of the second and third toes. Hereditary sclerodactyly is a rare condition, beginning in early youth with flexion contracture of the fingers. In this patient the skin of the fingers was sclerotic and thickened, and the dorsal skin of the hands was atrophic and dry. The condition did not progress nor did it show signs of Raynaud's phenomenon. Both feet showed syndactyly of the second and third toes. The family tree suggested autosomal dominant inheritance, with reduced penetrance since the grandfather of our patient was reported to have had a similar disease.

Genes, Dominant↗
PubMed1985

[Roaccutan in acne and rosacea].

Isotretinoin (Accutane) is a lately developed synthetic oral retinoid for treatment of severe forms of cystic acne resistant to therapy. Its pharmacological effect principally consists in decreased size of the sebaceous glands, reduced sebum production, as well as alteration of the bacterial micropopulation. At a dosage of 0.5 mg up to 1.0 mg/kg body weight daily, isotretinoin led to significant reduction of the inflammatory skin eruptions and long-lasting remission after discontinuation of the drug. With regard to 18 patients suffering from rosacea, the application of Accutane brought about satisfactory results, as well. Mucocutaneous side-effects were almost compulsory, but did never lead to discontinuation of the treatment. Because of its teratogenity, isotretinoin must not be applied in case of gravidity. Accutane offers new modes of therapy with respect to patients suffering from nodulocystic acne or severe rosacea which did not respond to common forms of treatment.

Acne Vulgaris↗
PubMed1985

[Preliminary results of Re-PUVA therapy in cutaneous T-cell lymphomas].

Eight patients with T-cell-lymphoma of the skin (6 mycosis fungoides, 2 parapsoriasis variegata) were treated with Tigason in combination with PUVA-therapy. The daily dose of Tigason was 50-100 mg. There was complete regression of skin lesions in three patients, partial regression in three patients, and an improvement in two patients.

Combined Modality Therapy↗
PubMed1985

[Dithranol and combined treatment procedures: pro and con].

The combination of different antipsoriatics or treatment regimens should increase the therapeutic effect and reduce the adverse reactions. The combination of dithranol and tar (cignolin-salicyl-vaseline + tar, CSVT) reduces dithranol erythema and increases the antipsoriatic effect. CSVT treatment is highly effective, but patients tend to accept it less than other treatment regimens. On the other hand, Goeckerman therapy (tar + UV irradiation) is more accepted but less effective. Combinations of dithranol with UV irradiation or with tar and UV irradiation (Ingram regimen) are not advantageous. Dithranol and Goeckerman therapy are relatively secure treatment regimens, as they have been applied for more than 50 years without knowledge of significant late defects. PUVA therapy, although highly effective, is not superior to dithranol therapy. Even though PUVA therapy is more easily accepted than dithranol treatment, PUVA therapy should be applied only in severe cases. The combinations of aromatic retinoid with (selective) UVB irradiation (ReSUP) or with PUVA therapy (RePUVA) are highly effective. Retinoids can reduce the UV doses and most likely limit the risk of late damage. For routine treatment, ReSUP is preferable to RePUVA therapy.

Anthracenes↗
PubMed1984

[Classical form of Kaposi sarcoma: immunology and interferon therapy].

T-lymphocytes and their subsets were determined in three patients with classical Kaposi's sarcoma. A reduction of pan-T-lymphocytes, including both a reduction of T-helper and T-suppressor cells, was found in one patient. None of the patients showed a reduction of the T-helper/T-suppressor cell ratio, as described in the lymphadenopathic disseminated type of Kaposi's sarcoma. Intradermal testing with tuberculin and trichophytin gave no indication of humoral immunodeficiency or anergy. In addition to electron beam irradiation, one female patient was treated with rIFN-alpha-interferon, 6 X 10(6) IU 3 times a week over a period of 3 months, and 18 X 10(6) IU 3 times weekly over 1 month. Under this therapy, irradiated as well as nonirradiated lesions become flatter, reduced in size and faded. The number of T-suppressor cells diminished.

Aged↗
PubMed1983

[Chemotherapy of cutaneous T-cell lymphomas with arotinoid].

Five patients with T-cell lymphoma of the skin (mycosis fungoides; Sézary syndrome) were given parenterally arotinoid ethyl ester (Ro 13-6298) at a daily dose of 0.5-4.0 micrograms/kg body weight, to a total dose of 20 mg over maximally 31 weeks. In three patients, among them one with tumourous mycosis fungoides, there was complete regression of the cutaneous lesions. In another patient the cutaneous changes, some of them with ulceration, regressed so that there were only residual infiltrates. In the case of the Sézary syndrome there was no response. Most important side-effects of treatment were cheilitis, moist and sticky skin, paronychia and dry mucosae. The most serious side-effect was pain in muscles, joints and bones. There were no significant changes in biochemical values during the treatment.

Adult↗
PubMed1983

Intermediate filaments of the vimentin and prekeratin type in human epidermis.

Monospecific antibodies to intermediate filaments of mesenchymally derived vimentin, applied to frozen sections of human skin, specifically stained dendritic basal and suprabasal cells. Cellular morphology, distribution, reaction pattern with anti-HLA-DR in serial sections, and OKT6 in double-staining procedures identified these cells as melanocytes and Langerhans cells. As shown previously in animals keratinocytes stained with antiprekeratin exclusively. Thus, vimentin is an intracellular marker for Langerhans cells and melanocytes, differentiating them from keratinocytes.

Cytoskeleton↗
PubMed1983

Anthralin inflammation versus UV-erythema in psoriatics.

Anthralin has been applied in low and high concentrations with and without UV-irradiation in the treatment of psoriasis (Schauder & Mahrle, 1982a,b). We have studied the relationship between the sensitivity to anthralin and UV-irradiation which might possibly help us to give a more individually adapted therapy.

Anthracenes↗
PubMed1983

Surgical treatment of recalcitrant warts.

Cryosurgery is the first choice for surgical treatment of viral warts. It is applied in two ways: with blister induction in extraplantar common warts and without blister induction in genital, filiform, and mosaic warts. Plantar and periungual warts are enucleated with a spoon or scraped off with a curet after preparatory focal electrocoagulation with a ball probe. Genital warts may be treated with "extracutaneous" electrosection and electrocoagulation.

Cryosurgery↗
PubMed1983

Intranuclear tonofilament-like filaments in skin carcinoma.

Electron microscopical investigations of untreated solar keratosis, squamous cell carcinoma, and Bowen carcinoma showed intranuclear bundles of intermediate filaments in suprabasal keratinocytes. We found evidence that the filaments are incorporated into the nucleus during atypical mitosis.

Aged↗
PubMed1983

Effect of vitamin A acid on homeostasis and differentiation of epidermal cells cultured on collagen.

Cultured guinea pig epidermal cells were treated with vitamin A acid (VA;2, 5, 10 micrograms/ml) and controlled by autoradiography and histochemical method. Cells attached to the bottom of the plates were counted and their number correlated with the number of cells sloughed off into the medium (A/D ratio). VA reduced the size of multilayered cell colonies, favoured cell spreading and accelerated confluence. It altered the mode of shedding since the cells sloughed off into the medium as isolated cells rather than cell complexes, as in untreated controls. It increased the A/D ratio in early cell cultures and decreased the A/D ratio in late cell culture. The higher the concentration of VA, the earlier and more prominent was the decrease of the A/D ratio. Low concentration of VA (2micrograms/ml) given once at seeding favoured the formation of keratohyalin and cornified envelopes whereas high concentration (5, 10micrograms/ml) given continuously prevented their formation and caused mucoid vacuolar degeneration of single cells. VA inhibited complete keratinization in all cases, but appeared to allow pre-keratinization, particularly at low concentrations. The results indicate that VA controls epidermal homeostasis in vitro by its influence on both proliferation and shedding. Its effect on the markers of differentiation is heterogeneous since it prevented keratinization in every case, but induced keratohyalin formation under certain conditions.

Animals↗
PubMed1983

[Cheilitis glandularis simplex].

Cheilitis glandularis simplex is a rather rare disease which has to be differentiated from cheilitis granulomatosa. The histological characteristics of cheilitis glandularis simplex are hypertrophy and hyperplasia of mucous and/or heterotopic salivary glands. The therapy is the excision of the tumor.

Adult↗