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Biomedical subjects

G Magro

Publications and source records attributed to G Magro.

At least 109 records · Page 6Linked to original sources
PubMed1994

Immunohistochemical staining patterns of type VI collagen in the normal, hyperplastic, and neoplastic adult male breast.

Ten cases of primary invasive male breast ductal carcinomas (N.O.S.), one case of male breast fibroadenoma, seven cases of pure florid gynecomastia and four cases of normal mammary glands were examined immunohistochemically for type VI collagen expression and distribution. In normal male breast type VI collagen was absent in the whole fibrous stroma. On the contrary this collagen was markedly expressed in the stroma of invasive carcinoma as well as fibroadenoma and gynecomastia. In all these proliferative diseases, type VI collagen gave a distinct basement membrane-like deposition at the epithelial-stromal junctions while organized a fibrillar network in the interstitium. Our immunohistochemical findings showed that type VI collagens is involved in the stromal response of benign and malignant male breast proliferative diseases.

Adult↗
PubMed1994

Minimal breast cancer: analysis of proliferative activity using a monoclonal antibody to proliferating cell nuclear antigen (PCNA) and its relationship to histological grade and prognosis.

Sixty-five cases of invasive breast cancer < or = 1 cm. in largest diameter (pT1a-b) were studied retrospectively using immunohistochemical staining with PC10, a monoclonal antibody to proliferating cell nuclear antigen (PCNA). The percentage of PC10 positive tumor cells was closely related to histological grading. No association was found between PC10 score and nodal status. ER-ICA was performed on 42 cases and showed no correlation with PC10 staining. The clinical behaviour of these tumors was excellent, with 5-year survival rates overall of 96% (90% disease free survival), and apparently unrelated to histological type and grade, nodal involvement and hormonal receptor status. The prognostic value of PCNA labeling rates remains nuclear in breast cancer of minimal size as well as in larger ones.

Adult↗
PubMed1993

Prevention of cyclophosphamide-induced diabetes in the NOD/WEHI mouse with deoxyspergualin.

Ten out of 20 (50%) 17-week-old female NOD/WEHI mice developed an acute form of autoimmune diabetes when injected with two large doses of cyclophosphamide (CY), given at 14-day intervals. If these mice were treated under a prophylactic regimen with 2.5 mg/kg body weight per day of the novel immunosuppressant deoxyspergualin (DSP) the onset of diabetes was completely prevented. Moreover, DSP-treated animals showed reduced signs of pancreatic insulitis, had lower percentages of splenic lymphoid cells (SLC) expressing IL-2 receptors and Ly-6C antigens on their surfaces, and these cells released lower amounts of interferon-gamma (IFN) when stimulated in vitro. These data, providing evidence for the capacity of DSP to protect NOD/WEHI mice from experimental autoimmune diabetes and to modulate histo-immunological pathogenic pathways, indicate DSP as a drug of potential interest in the treatment of human insulin-dependent diabetes mellitus.

Animals↗
PubMed1990

[Evaluation of the changes in glycosylated hemoglobin in a sample of hospitalized diabetic patients. Significance and limitations of this diagnostic method].

Stable glycosylated hemoglobin measurement provides an index for plasma glucose control over an average three month period. It is not clear whether stable HbA1C can undergo rapid changes induced by short-term variations in glucose concentration. The present study was aimed at investigating whether variation of total HbA1C in response to changes in blood glucose, over a short period can be detected by routine methods of determination. Our result show that due to the sensitivity of the methods, stable HbA1C has to be considered only as an index of glucose control over long period of time.

Adult↗