Search PubMed⌕ Search

Biomedical subjects

G Maggi

Publications and source records attributed to G Maggi.

At least 109 records · Page 6Linked to original sources
PubMed1987

[Prevention of deep venous thrombosis with defibrotide in chest surgery. Controlled multicenter study versus heparin].

The effectiveness and tolerability of defibrotide in the prevention of post-surgery deep vein thrombosis (DVT) were compared with those of heparin in a multicentric randomized controlled study. One hundred-eight-four both sexes patients submitted to thoracic surgery were randomly allocated to defibrotide (400 mg b.i.d. by IV route, n = 94) or to calcium heparin (5000 I.U. t.i.d. s.c., n = 90); both treatments were started the day before the operation and withdrawn when patients were allowed to stand up (i.e., after 7 days). No patients developed DVT in the defibrotide group, while a single case of DVT was detected in the heparin group; furthermore, a more prominent bleeding was observed in the latter, in the early post-operative period (normal bleeding: 2nd day: defibrotide 70/92 pts, heparin 53/90 pts, p less than 0.02; 3rd day: defibrotide 87/92 pts, heparin 76/90 pts, p less than 0.05, chi 2 test), while the healing rate of surgical wounds was similar in the two groups. No relevant modifications in laboratory parameters were seen throughout the observation period. Thus, these preliminary data suggest that defibrotide is at least as effective as heparin in the prevention of post-thoracic surgery DVT and that the former drug has a possibly better tolerability profile, due to a lesser tendency to bleeding.

Adult↗
PubMed1986

Thymomas. A review of 169 cases, with particular reference to results of surgical treatment.

One hundred sixty-five patients with surgically treated thymoma were followed over 28 years; 73% had myasthenia gravis at presentation. Invasiveness was based on macroscopic findings at operation. Postsurgical radiotherapy or chemotherapy were not routinely used. Overall survival was 84%, 79%, and 65% at 3, 5, and 10 years, respectively. Patients with invasive thymoma survived for a shorter period than patients with noninvasive tumors (67% versus 85% at 5 years); when radical excision was possible, no difference was detectable between the two groups. Patients with subtotally resected or only biopsied invasive thymomas survived 59% and 42% at 5 years, respectively. Lymphoepithelial cases had the worst prognosis of the histologic types considered. Myasthenia gravis did not adversely affect survival. Surgery is the basic treatment of thymomas. Macroscopic invasiveness and degree of excision judged by the surgeon have prognostic value and are reliable criteria of malignancy. Radiotherapy and chemotherapy may be effective, but their use should be limited to controlled trials.

Adolescent↗
PubMed1986

Neurogenic intrathoracic tumors. A clinicopathological review of 92 cases.

Ninety-two cases of intrathoracic neurogenic tumors operated on between 1950 and 1982 are reviewed. The benign forms (86 cases, 93.5%) included 23 ganglioneuromas, 50 neurilemmomas and 13 neurofibromas. Of the latter, 4 occurred in patients with Von Recklinghausen's disease. A double local recurrence was observed after the removal of a neurilemmoma. One of the patients with generalized neurofibromatosis died 5 months after operation from local sarcomatous degeneration and distant metastases. In this group of benign lesions, no other death was observed which could be attributed to the endothoracic neural tumor. The malignant forms (6 cases, 6.5%) included 4 ganglioneuroblastomas and 2 neurofibrosarcomas. The surgical excisions were described as radical in every case and all the patients were given radiotherapy postoperatively. One patient with ganglioneuroblastoma died from metastases 2 years later, and one with neurofibrosarcoma from local recurrences 7 months later. One patient with neurofibrosarcoma and 3 with ganglioneuroblastomas are alive and well 4, 5, 6 and 11 years, respectively, later. Surgical excision remains the best method of diagnosing and treating endothoracic tumors of neural origin. Of special interest are the "dumbbell" or hourglass tumors and lesions which occur in Von Recklinghausen's disease.

Adolescent↗
PubMed1985

[Etiologic determination of chronic liver diseases].

Sixty patients with chronic liver conditions (mostly cirrhotic) were examined for HBV markers. The percentage of markers identified, far higher than in samples of healthy subjects, suggests that HBV either alone or in association with other causes may be implicated in the pathogenesis of these conditions.

Chronic Disease↗
PubMed1985

[Immuno-oncologic monitoring of patients with bronchial carcinoma. IV. Aspects of the immunocompetence system].

Some aspects of the immunocompetent system are tested in 84 lung cancer patients at time of diagnosis and during the natural course of the disease. Results show no significant variations for many immunological tests during the course of the neoplasia. Significant alterations are observed in T-lymphocyte and macrophage evaluation. Moreover, some immunological data are related to lung cancer post-surgical survival.

Adenocarcinoma↗
PubMed1985

[Immuno-oncologic monitoring of patients with bronchial carcinoma. II. Plasma fibronectin determination].

Recent attempts implicating glycoproteins have been focused on the study of fibronectin. This glycoprotein was observed especially in cellular adhesivity processes. Some works were direct to detect the fibronectin concentration in plasma and in other biological fluids to relate increased or decreased levels in pathological features. In this paper we describe a study on plasma fibronectin in lung cancer patients during the course of the disease.

Fibronectins↗
PubMed1985

[Immuno-oncologic monitoring of patients with bronchial carcinoma. I. Carcinoembryonic antigen (CEA)].

Plasma levels of carcinoembryonic antigen (CEA) were determined in 82 lung cancer patients before surgery and during the clinical course of the disease. Results were compared to those obtained in normal controls and in patients with lung inflammatory diseases. Furthermore, relationships between plasma CEA levels and survival were carried out. While CEA levels were not useful to make differential diagnosis, in our study, we hypothized the possibility to use CEA in prognostic evaluations.

Bronchial Diseases↗
PubMed1984

[Surgical therapy of tuberculosis].

Authors report the indications of surgical treatment of tuberculosis. At present undoubtedly these indications so diminished that now they are only the following: rare stabilized results; adenobronchial syndromes with their complications; indications of rescue in drug-resistant lesions; operations in subjects with results of treatments made in pre-antibiotic time; presence of rigid cavities. The surgery of tuberculosis has become more and more unusual, but in spite of that this surgery is complicated for the surgeon operates an inflammatory tissue with solid adhesions on the blood-vessels and on the near structures.

Anti-Bacterial Agents↗