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Biomedical subjects

G Machnik

Publications and source records attributed to G Machnik.

52 records · Page 3Linked to original sources
PubMed1985

[Stomach cancer survival rates].

The cumulative 5-year survival rates in the case material of the years 1979-1983 with endoscopically-histologically confirmed gastric carcinoma were compared to those of the 1974-1978 period, particularly with reference to operative therapy and the histological type of carcinoma. The percentage of curatively operated patients increased from 40.6 to 49.7%, the rate of non-operated patients fell from 42.5 to 22.4%. The histological evaluation revealed a rise in the percentage of the adenocarcinoma from 37.1 to 53.5%-while the percentage of the solid carcinoma decreased from 29.1 to 15.5%. Following curative therapy, the calculated cumulative 5-year survival rate rose from 35.6 to 51.8% in men, however, fell from 66.2 to 48.3% in women. Most recent investigations showed men with curatively operated adenocarcinoma to have the best survival rate (60.6%); in women, this is true of mixed-type carcinoma.

Adenocarcinoma↗
PubMed1985

[The so-called dihydralazine hepatitis. A contribution to the pathogenesis].

Liver injuries following application of dihydralazine in 14 patients, ten of them with the typical pattern of perivenous liver cell necrosis, are reported. The other 4 patients, all having been exposed to additional hepatotoxic substances, histologically showed mixed patterns of tissue injury in liver biopsy. Moreover, in 6 of 14 patients there were diseases in the upper abdomen and/or metabolic disorders as well as an exposition to chemical hepatotoxic substances, or an additional application of potential hepatotoxic drugs. 9 of 14 patients had been treated with propranolol and dihydralazine simultaneously. One female patient showed the typical morphologic pattern of 'dihydralazine-damage' after application of propranolol only. In 3 cases with reexposition of dihydralazine merely one of them developed the typical histological behaviour documented in the literature. Distinct fibrosis of the liver remained in 2 cases. Consequently, to the hitherto existing pathogenetic concept of dihydralazine-caused liver injury as a metabolic-toxic-allergic one, there is to be added the new aspect of summing up of the actions of various additional noxious agents.

Adult↗
PubMed1979

[Value and results of coloscopic polypectomy].

From August 1976 till the end of February 1979 158 polyp in 83 patients (48 male and 35 female) were removed by means of the rectocoloscopic polypectomy with the high frequency diathermy loop. 66% of the polypi had a diameter of less than 1 cm. Most the polypi were with about 70% in the sigma and in the rectum. With 60.7% the adenomas appeared most frequently, followed by the hyperplastic polypi in 20% and by the inflammatory ones in 13.3% of the cases. With the increase of size of the polypi the proportion of the adenomas clearly increased in comparison to the other kinds of polypi. Severe epithelial atypias (altogether 23.1%) were more frequently in adenomas larger than 2 cm than in smaller ones. An invasive carcinoma was found in no polypus. Thus the endoscopic polypectomy in every case meant a curative therapy with great economic use. In patients a haemorrhage appeared as a complication of the coloscopic polypectomy. Only the removal of the polypi in toto allows an exact histological classification and the answer of the decisive question, whether in one adenoma only severe epithelial atypias are present and thus the polypectomy is therapeutically sufficient or whether there exists an adenocarcinoma, for the removal of which an operation according to the principles of the carcinoma surgery must be carried out. The endoscopic ablation of the adenomas thus means a genuine prophylaxis of cancer.

Adenocarcinoma↗
PubMed1979

[Causes, shape and chemistry of gallstones].

Gallstones are precipitations of oversaturated bile fluid. They can develop in the gallbladder and in the efferent bile ducts; they are very often correlated with diseases of the gallbladder, bile ducts and neighboring organs. The gallstone disease (cholelithiasis) is increasing continually, especially in developed countries with overcaloric nourished population. Surgical interventions on the biliary tract are the most frequent abdominal operations at present.

Bile↗
PubMed1979

Studies on the quantification of local tissue injury following intramuscular injection of aqueous solutions. VIII. The local lesion after application of turimycin in different preparations.

The increase in drug concentration in aqueous solutions is not responded to by a comparable enlargement of volume of necrosis after intramuscular injection. After application of TURIMYCIN the lesion is more voluminous than those caused by penicillin, lower than those following OTESOLUT and nearly equal to those caused by 5% WOFAPYRIN (phenylbutazone + aminophenazone 1:1).

Animals↗
PubMed1978

[Frequency of pathological liver changes in biopsy and autopsy samples (author's transl)].

It is the purpose of this study to point out the epidemiological importance of pathoanatomical records. In this connections, it is necessary to pay attention to different prerequisites for documentation, especially to an agreement on diagnostical nomenclature. Liver alterations and liver diseases are given as an example for valueing the relevance of both bioptic and autoptic materials for epidemiological purposes. By means of about 8,500 liver biopsies and 1,000 autopsies from the same territorial region the type and frequency of the different pathological alterations of the liver are compiled. Their frequency differs about ten fold. The epidemiological value obviously lies in specially aimed investigations; on the other hand, autoptic examinations are more representative and therefore of higher general reliability and greater epidemiological value.

Adolescent↗
PubMed1974

[Morphometry of endocrine organs. 2. Karyometry of dog and swine thyroid glands following administration of TURISYNCHRON and SUISYNCHRON].

Administration of TURISYNCHRON (metallibure) to dogs at 1 mg/kg/day for six months did not affect the histological structure of the thyroid, but the volume of nuclei of thyroid epithelial cells was reduced by one-third. In pigs given 100 mg/animal daily for 100 days, this nuclear contraction amounted to only 11%. Metallibure zinc complex (TURISYNCHRON-Z, SUISYNCHRON) given at 1 and 10 mg/kg/day for six months had a similar action on the thyroid.

Animals↗