[Experimental thrombasthenia and Bernard-Soulier syndrome induced with anti-platelet antibodies].
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Adult↗
Biomedical subjects
G M Tobelem
Publications and source records attributed to G M Tobelem.
[Letter: Platelet C1 in lymphoid syndromes].
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Blood Platelets↗
C1 and human platelets. II. Detection by immunological methods and role.
A C1 haemolytic activity was previously shown to be associated with platelets. The presence of C1 on human gel filtered platelets is confirmed by Ouchterlony analysis, and platelet aggregation induced by anti-c1 q antisera. After cleavage of C1 by EDTA, platelet aggregation induced by aggregated was decreased and was restored by the addition of C1. The possible role of C1 in human platelet aggregation induced by aggregated immunoglobulins or immune complexes is discussed.
Blood Cell Count↗
C1 and human platelets. Decrease in chronic lymphocyte leukemia. Effect of lymphocytes.
Studies of platelet C1 have been performed in 11 patients with chronic lymphocytic leukemia (CLL). The platelet C1 level evaluated by the hemolytic method was very low and the platelet aggregation induced by aggregated IgG or anti C1q antisera was significantly reduced. "In vitro", the lymphocytes from CLL were capable of inhibiting platelet C1 and platelet aggregation induced by aggregated IgG and anti C1q to a greater extent than normal lymphocytes. These results lead the authors to discuss the role of platelet C1 in the interaction platelet/immunoglobulins and the nature of the inhibition.
Blood Platelets↗