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Biomedical subjects

G M Stevens

Publications and source records attributed to G M Stevens.

At least 19 recordsLinked to original sources

Performance of a static-anode/flat-panel x-ray fluoroscopy system in a diagnostic strength magnetic field: a truly hybrid x-ray/MR imaging system.

Minimally invasive procedures are increasing in variety and frequency, facilitated by advances in imaging technology. Our hybrid imaging system (GE Apollo flat panel, custom Brand x-ray static anode x-ray tube, GE Lunar high-frequency power supply and 0.5 T Signa SP) provides both x-ray and MR imaging capability to guide complex procedures without requiring motion of the patient between two distant gantries. The performance of the x-ray tube in this closely integrated system was evaluated by modeling and measuring both the response of the filament to an externally applied field and the behavior of the electron beam for field strengths and geometries of interest. The performance of the detector was assessed by measuring the slanted-edge modulation transfer function (MTF) and when placed at zero field and at 0.5 T. Measured resonant frequencies of filaments can be approximated using a modified vibrating beam model, and were at frequencies well below the 25 kHz frequency of our generator for our filament geometry. The amplitude of vibration was not sufficient to cause shorting of the filament during operation within the magnetic field. A simple model of electrons in uniform electric and magnetic fields can be used to estimate the deflection of the electron beam on the anode for the fields of interest between 0.2 and 0.5 T. The MTF measured at the detector and the DQE showed no significant difference inside and outside of the magnetic field. With the proper modifications, an x-ray system can be fully integrated with a MR system, with minimal loss of image quality. Any x-ray tube can be assessed for compatibility when placed at a particular location within the field using the models. We have also concluded that a-Si electronics are robust against magnetic fields. Detailed knowledge of the x-ray system installation is required to provide estimates of system operation.

Electromagnetic Fields↗

A truly hybrid interventional MR/X-ray system: feasibility demonstration.

A system enabling both x-ray fluoroscopy and MRI in a single exam, without requiring patient repositioning, would be a powerful tool for image-guided interventions. We studied the technical issues related to acquisition of x-ray images inside an open MRI system (GE Signa SP). The system includes a flat-panel x-ray detector (GE Medical Systems) placed under the patient bed, a fixed-anode x-ray tube overhead with the anode-cathode axis aligned with the main magnetic field and a high-frequency x-ray generator (Lunar Corp.). New challenges investigated related to: 1) deflection and defocusing of the electron beam of the x-ray tube; 2) proper functioning of the flat panel; 3) effects on B0 field homogeneity; and 4) additional RF noise in the MR images. We have acquired high-quality x-ray and MR images without repositioning the object using our hybrid system, which demonstrates the feasibility of this new configuration. Further work is required to ensure that the highest possible image quality is achieved with both MR and x-ray modalities.

Brain↗

Filtered backprojection for modifying the impulse response of circular tomosynthesis.

A filtering technique has been developed to modify the three-dimensional impulse response of circular motion tomosynthesis to allow the generation of images whose appearance is like those of some other imaging geometries. In particular, this technique can reconstruct images with a blurring function which is more homogeneous for off-focal plane objects than that from circular tomosynthesis. In this paper, we describe the filtering process, and demonstrate the ability to alter the impulse response in circular motion tomosynthesis from a ring to a disk. This filtering may be desirable because the blurred out-of-plane objects appear less structured.

Animals↗

Alignment of a volumetric tomography system.

A test-bed system has been developed for imaging phantoms with tomosynthesis and volumetric computed tomography. This system incorporates an amorphous silicon flat panel detector on a movable gantry and a computer-controlled rotational positioning stage. In this paper, an analysis of the sensitivity of reconstructed images to geometrical misalignment is presented. Application of this method to circular digital tomosynthesis is examined, with spatial resolution in the focal plane as the criterion for evaluating the effect of misalignment. A software-based method is presented for correcting data for imperfect system alignment prior to image reconstruction. Experimental results yield reconstructed images with spatial resolution approaching the theoretical limit based on detector pixel size and accounting for data interpolation.

Algorithms↗

Depth-segmented detector for x-ray absorptiometry.

A new energy-dependent multi-cell detector, which is a generalization of the conventional front-back detector, was studied using computer simulations. The noise performance of the detector for bone quantitation was examined in comparison to an ideal energy discriminating detector, and front-back detectors with and without inter-detector filters. The front-back detectors were optimized for a reference object composed of water and bone, and then compared to the new detector over a range of object compositions. In this paper, precision in calculated bone thickness is used as the criterion for evaluating detector performance. Simulations show that the segmented detector always performs better than the front-back detector without an inter-detector filter. It outperforms the detector incorporating a filter by an amount that depends on the heterogeneity of the x-ray spectrum. In addition, for single component radiographic images, this multi-cell detector retains information which is lost in the front-back detector with a filter layer.

Absorptiometry, Photon↗

Outpatient needle biopsy of the lung: its safety and utility.

Four hundred forty-seven needle biopsies of the lung were carried out on 348 patients in a nonhospital outpatient setting. There were no fatalities or serious complications. A reliable working diagnosis was obtained in 74% of patients (86% true positive for malignancy). Diagnostic thoracotomy was avoided in 31%, and the diagnostic interval was shortened in most. Impressive economic benefits resulted. Careful postbiopsy evaluation revealed pneumothorax in 41% of patients, with 10% requiring chest tube drainage, usually on an ambulatory basis. With management of the infrequent complications by the radiologist, outpatient needle biopsy of the lung can be safe, reliable, and highly cost effective.

Ambulatory Care↗