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Biomedical subjects

G M Sterling

Publications and source records attributed to G M Sterling.

7 recordsLinked to original sources
PubMed1987

Anticholinergic therapy in chronic asthma.

Although 'chronic asthma' is a loosely defined disease, it may be equated approximately with non-allergic or 'intrinsic' asthma arising in adult life. In patients with this condition anticholinergic agents, particularly ipratropium bromide, have been shown to have a useful and rather prolonged bronchodilator action. This bronchodilatation approaches that achieved by therapeutic doses of Beta-agonists and is not associated with undesirable effects such as difficulty in sputum clearance. In conclusion anticholinergic agents are a safe and useful adjunct to other bronchodilators in patients with chronic asthma.

Administration, Inhalation↗
PubMed1979

Ventilation.

Explore the source record for details and available documents.

Carbon Dioxide↗
PubMed1978

The effect of alpha-adrenoreceptor stimulation on the airways of normal and asthmatic man.

1. The bronchial response to alpha-adrenoreceptor stimulation has been investigated in normal and asthmatic subjects with a specific alpha-receptor agonist, methoxamine hydrochloride, after atropine and beta-adrenergic blockade. 2. No significant changes in forced expiratory volume in 1 s (FEV1.0) were seen in normal subjects. 3. Methoxamine inhalation caused mild symptomatic wheezing and significant falls in FEV1.0 in asthmatic subjects. No change in FEV1.0 occurred after inhalation of distilled water as control. 4. It therefore appears that methoxamine causes bronchoconstriction in asthmatic subjects through its alpha-adrenergic-stimulating properties, since we were not able to detect any beta-receptor-blocking activity of methoxamine on the airways.

Adult↗
PubMed1978

Beta-blockers and asthma.

In a single-blind, randomised, crossover study in 10 asthmatic patients, the effects of approximately equipotent oral doses of 3 cardioselective beta-blockers-atenolol (100 mg), metoprolol (100 mg), and acebutolol (300 mg)-and 4 non-cardioselective beta-blockers-proranolol (100 mg), oxprenolol (100 mg), pindolol (5 mg), and timolol (10 mg) upon FEV1 were compared. All drugs, except pindolol, produced a significant reduction in standing pulse rate and prevented an increase in heart rate after inhaled isoprenaline (1500 microgram). All drugs caused a fall in FEV1 but only atenolol did not differ significantly from placebo in this respect. The bronchodilator response to inhaled isoprenaline was blocked by the 4 non-cardioselective drugs; the 3 cardioselective agents permitted some bronchodilatation, but only atenolol did not differ from placebo.

Adolescent↗
PubMed1978

Hypercalcaemia and hypokalaemia in tuberculosis.

In two patients with extensive pulmonary tuberculosis who developed hypercalcaemia and hypokalaemia the hypercalcaemia appeared related to the use of small doses of vitamin D, which suggested patients with tuberculosis were hypersensitive to vitamin D. They were thus similar to patients with sarcoidosis, and it is interesting that the Kveim test result was positive in both cases. The hypercalcaemia was quickly suppressed with steroids. Hyperparathyroidism, thyrotoxicosis, Addison's disease, and multiple myeloma were excluded on clinical grounds and by the appropriate tests. The hypokalaemia was associated with increased renal excretion of potassium, and was probably due to distal tubular damage from hypercalcaemia.

Adult↗