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Biomedical subjects

G M Kavanagh

Publications and source records attributed to G M Kavanagh.

36 records · Page 2Linked to original sources

Weathering nodules of the ear: a clinicopathological study.

Twenty-five cases of distinctive ear nodules on the helices of the ears in elderly males are presented. We believe the clinicopathological features of these lesions allow them to be defined as a distinct entity. They are probably more common than is currently recognized. Histologically, a typical nodule comprises a spur of fibrous tissue with a focus of cartilage metaplasia. While the pathogenesis of weathering nodules remains unclear, there is an association with age and chronic UV exposure.

Adult↗

Multiple clear cell acanthomas treated by cryotherapy.

Clear cell acanthoma is usually a solitary lesion. We report a patient with multiple lesions demonstrating the typical clinical and histological features of clear cell acanthoma, which responded well to treatment with liquid nitrogen.

Cryosurgery↗

A case of Grzybowski's generalized eruptive keratoacanthomas.

We report a case of Grzybowski's generalized eruptive keratoacanthoma which demonstrates the characteristic features of this rare condition. The recurring nature of the eruption each summer supports the suggestion that UV irradiation may act as a precipitating factor in eruptive keratoacanthoma.

Humans↗

Hypertrichosis and algodystrophy: an hypothesis to explain this uncommon association.

Various skin changes have been described in algodystrophy, but the association of hypertrichosis with this condition is poorly documented. We describe a patient who developed algodystrophy after a mild inflammatory arthritis, in association with a number of skin manifestations, including hypertrichosis. We suggest a mechanism to explain this particular association.

Adult↗

Juvenile dermatomyositis associated with partial lipoatrophy.

A 26-year-old woman developed partial lipoatrophy 12 years after juvenile dermatomyositis was diagnosed. Renal function was normal, but she had other features typically associated with partial lipoatrophy, including hepatomegaly, acanthosis nigricans, hypertrichosis, and hyperinsulinemia.

Adult↗

Erythema elevatum diutinum associated with Wegener's granulomatosis and IgA paraproteinemia.

A 69-year-old man had erythema elevatum diutinum for several years before he developed IgA paraproteinemia and a limited form of Wegener's granulomatosis. This is the first report of an association between erythema elevatum diutinum and Wegener's granulomatosis. IgA paraproteinemia has been reported in association with erythema elevatum diutinum but not with Wegener's granulomatosis.

Aged↗

Folliculitis in Down's syndrome.

Twenty-two male and 20 female adults with Down's syndrome were examined. Ten of the men and two of the women had a follicular rash consistent with Malassezia folliculitis. Oral itraconazole treatment produced a significant improvement in the rash, accompanied by a decrease in the skin Malassezia count. Clinical relapse occurred when therapy was discontinued, and was accompanied by return of the Malassezia yeasts.

Administration, Oral↗

Necrobiosis lipoidica--involvement of atypical sites.

Necrobiosis lipoidica (NL) has distinctive clinical and histological appearances. The legs are the commonest site of involvement, and 85% of cases involve the legs exclusively. We describe a patient in whom NL did not involve the legs, but was found to occur on unusual areas: the back and nipple. This is possibly the first report of NL affecting the nipple.

Adult↗

Giant primary mucinous sweat gland carcinoma of the scalp.

Primary mucinous sweat gland carcinoma is a rare tumour which usually behaves in a relatively benign manner. This is illustrated by the massive proportions which this tumour reached in the case described, without evidence of metastases.

Adenocarcinoma, Mucinous↗

Recalcitrant pyoderma gangrenosum--two cases successfully treated with cyclosporin A.

The successful use of cyclosporin A (CSA) in organ transplantation is now well established. In recent years its usefulness has extended to the treatment of cutaneous autoimmune disorders, including pyoderma gangrenosum (P.G.). We report two further cases of recalcitrant P.G., both associated with rheumatoid arthritis (R.A.) which responded to low dose CSA.

Aged↗