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Biomedical subjects

G M Edington

Publications and source records attributed to G M Edington.

At least 37 records · Page 2Linked to original sources
PubMed1972

A clinicopathological study of human yellow fever.

During an epidemic of yellow fever in the Jos Plateau area of Nigeria, 9 adult males with clinically diagnosed yellow fever were studied by haematological, biochemical, virological, serological, and liver biopsy methods. The ages of the patients ranged from 20 to 55 years and the duration of illness was 3-62 days. No virus was isolated from any patient but all patients should biochemical evidence of severe hepatocellular damage. Leucopenia was a feature of the late acute stage of the disease. Five sera had antibodies to yellow fever at titres greater than 1: 32, 3 of them being monospecific for yellow fever. The classical histological features of yellow fever were present only in the acute or late acute stages, when complement-fixation tests may be negative. With convalescence and the production of complement-fixing antibodies in high titres, the histological features resembled those of a persisting nonspecific hepatitis. In an endemic area, the histological features of yellow fever will depend on the stage of the disease and a picture of nonspecific hepatitis would not exclude yellow fever in the absence of confirmation from serological tests.

Adult↗
PubMed1971

Human alpha fetoprotein in body fluids.

Human alpha fetoprotein (AFP) has been detected by the agar double diffusion method in ascitic fluid, cerebrospinal fluid (CSF) and bile, from fetuses, neonates and patients with AFP seropositive hepatocellular carcinoma. AFP was detected in the meconium and faeces of fetuses and neonates respectively. The protein was not detected in the amniotic fluid nor the pericardial fluid. It was found in the urine in only two fetuses that had concomittant renal disease. It was not detected in breast milk of lactating females. When metastases occurred in the lung from a hepatocellular carcinoma producing AFP, the pleural effusions sometimes contained AFP. The concentrations of AFP in the serum and in the other body fluids were about the same. This indicates that other body fluids can be used for the diagnosis of hepatocellular carcinoma.

Adult↗
PubMed1971

Immunofluorescent localisation of human alpha feto-protein in fetal and neonatal livers and cultured cells from hepatocellular carcinoma.

The indirect immunofluorescence technique demonstrated that human alpha fetoprotein (AFP) was present in a focal pattern in the cytoplasm of malignant liver cells of patients whose sera contained AFP. A few fibroblastlike cells in tissue culture of liver biopsies from patients with hepato-cellular carcinoma and AFP in their sera also had the protein. The intracellular localisation of human AFP was confirmed by centrifugation of washed, homogenised and ultra-sonically disrupted neonatal liver cells. Examination of livers of fetuses and neonates showed that AFP was present predominantly in the periportal parenchymal cells.

Adult↗