Biomedical subjects

G M Addison

Publications and source records attributed to G M Addison.

At least 55 records · Page 3Linked to original sources

PubMed1986

Blood glucose in anaesthetised children. Comparison of blood glucose concentrations in children fasted for morning and afternoon surgery.

Blood glucose levels were measured immediately after induction of anaesthesia and again intraoperatively in 26 children fasted overnight for operations in the morning and 28 children fasted from 8.00 a.m. for afternoon surgery. The mean post-induction glucose concentration of the afternoon surgery group was significantly lower than that of the morning group. However, no child in either group was hypoglycaemic. Anesthesia and surgery caused significant increases in blood glucose levels. It is concluded that pre-operative fasting is well tolerated in healthy pre-school children, regardless of the timing of surgery.

Anesthesia, General↗

PubMed1986

Determination of chlorpromazine in serum by radioreceptor assay and HPLC.

A radioreceptor assay for chlorpromazine in serum, which is based on binding to dopamine receptors, is described. This method has been postulated to measure all active metabolites as well as the parent drug. We have compared this method with an HPLC method for chlorpromazine. Dopamine-blocking activity, measured in serum samples from schizophrenic patients receiving chlorpromazine, was 1.85-9.1 times higher than serum chlorpromazine level measured by HPLC. The correlation between the two methods was 0.75. Dopamine-blocking activity was related more closely to dose of drug and to serum prolactin level than was serum chlorpromazine level measured by HPLC.

Chlorpromazine↗

PubMed1985

Raised serum immunoreactive trypsin in the haemorrhagic shock and encephalopathy syndrome.

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Brain Diseases↗

PubMed1985

Renal function in diabetes mellitus.

Glomerular filtration rate, day and night-time albumin excretion, and blood pressure were estimated in 83 children with diabetes mellitus and compared with measures of glycaemic control, age, and duration of disease. Careful attention was paid to definition of normal values in age matched controls. The glomerular filtration rate was greater than normal, and correlated with duration of disease, but not with albumin excretion or blood pressure. Daytime albumin excretion correlated with duration of disease and glycosylated haemoglobin, but not with age, glomerular filtration rate, or blood pressure. Night-time albumin excretion was significantly raised and correlated with duration of disease, glycosylated haemoglobin, mean blood sugar concentration, and M value but not with age, glomerular filtration rate, or blood pressure. Diastolic blood pressure was significantly raised but was not correlated with any other measured variable. We have confirmed abnormalities of renal function in a children's diabetic clinic. The measurement of overnight albumin excretion rates may provide a sensitive early indicator of renal damage.

Adolescent↗

PubMed1985

Albumin analysis in serum of haemodialysis patients: discrepancies between bromocresol purple, bromocresol green and electroimmunoassay.

The analysis of serum albumin by bromocresol purple (BCP), by bromocresol green (BCG), and by electroimmunoassay (EIA) has been compared in a mixed group of 100 hospital patients. Good agreement between the immunochemical and BCP methods, but a positive bias with the BCG method led to routine use of the BCP method. In a group of 19 paediatric patients on chronic haemodialysis the mean BCP-albumin was found to be lower than the true albumin, as determined by EIA, whereas the positive bias using the BCG method remained. The difference between BCP-albumin and EIA-albumin in the haemodialysis group varied from 0 to -13 g/L (mean -7.1 g/L) but was effectively constant for most patients over a 3-month period. Possible mechanisms and necessary further investigations are discussed.

Adolescent↗

PubMed1985

Interference in a two-site immunoradiometric assay for thyrotropin in a child.

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Antibody Specificity↗

PubMed1984

Fragments of myelin basic protein derived from human brain are not mitogenic in cultures of human amniotic fluid cells and other cells.

The possible mitogenic effects of a number of preparations of the myelin basic protein (MBP) of human brain have been investigated in various cell types in culture, including human amniotic fluid cells. Intact human MBP, as well as fragments derived by BNPS-skatole and cathepsin D treatment, and isoelectric focusing fractions of human MBP, showed no mitogenic activity. These results are consistent with recent findings that the fibroblast growth factor (FGF) activity of bovine brain does not originate from MBP.

Amniotic Fluid↗

PubMed1983

Zinc supplementation and its effect on taste acuity in children with chronic renal failure.

Diminished taste acuity (hypogeusia) and zinc deficiency have been reported in children on maintenance haemodialysis and with varying degrees of chronic renal failure. We have studied the effect of 6 weeks' zinc supplementation in 20 children with chronic renal impairment using a double-blind crossover trial. Although we achieved significant increases in serum zinc levels no significant improvement in taste acuity could be demonstrated. These studies provide no support for the belief that routine zine supplements are necessary in children with chronic renal failure.

Adolescent↗

PubMed1980