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Biomedical subjects

G Lundgren

Publications and source records attributed to G Lundgren.

At least 91 records · Page 5Linked to original sources
PubMed1983

Increased mortality by septicemia, interstitial pneumonitis and pulmonary fibrosis among bone marrow transplant recipients receiving an increased mean dose rate of total irradiation.

Seven bone marrow transplant recipients with acute lymphoblastic leukemia receiving a mean dose rate of 0.07 Gy/min of total body irradiation towards the pelvic midpoint and the lungs had an increased (p less than 0.01) overall death rate of 86 per cent compared with 33 per cent among 27 patients with acute non-lymphoblastic leukemia or acute lymphoblastic leukemia treated with a mean dose rate of 0.04 Gy/min. Among the patients receiving the higher dose rate there was an increased mortality in causes related to radiation toxicity like early septicemia, interstitial pneumonitis and pulmonary fibrosis, compared with all patients receiving the lower dose rate (p less than 0.01) and also with 10 patients from this group with acute lymphoblastic leukemia (p less than 0.02).

Acute Disease↗
PubMed1983

Markedly elevated serum IgE levels following allogeneic and syngeneic bone marrow transplantation.

Serum IgE levels were studied in 25 bone marrow transplant recipients (in 12 patients twice weekly and in 13 patients, at random). A 2-748-fold increase in serum IgE was recorded in 20 of the 25 patients after transplantation, the highest IgE value observed being 8,000 kU/liter. The IgE elevation appeared concomitantly with acute graft-versus-host disease (GVHD) in 14 patients. Both events occurred on day 24 +/- 2 (mean +/- SE). When the acute GVHD was diagnosed, there was a significant increase in serum IgE as compared to the first posttransplantation value. In one patient in whom GVHD recurred, a second IgE peak was seen, and in another patient with flaring GVHD, IgE levels increased on several occasions. In 6 patients without clinical signs of GVHD, a rise in IgE occurred on day 35 +/- 12. One of these patients was grafted with marrow from her identical twin. The rise in IgE did not correlate with an elevated proportion of eosinophil granulocytes. In the majority of the patients, no correspondent increases in serum IgG, IgA, or IgM were seen during the period with increased IgE after transplantation.

Adolescent↗
PubMed1982

Successful outcome of segmental human pancreatic transplantation with enteric exocrine diversion after modifications in technique.

Segmental pancreatic transplantation is now the most widely favoured form of pancreatic transplantation, but the major difficulty with this procedure is the handling of the exocrine secretion. The use of a pancreaticoenteric anastomosis for exocrine diversion has been re-evaluated and several ancillary measures to reduce the risk of fistula and bacterial contamination have been applied. In three consecutive patients there have been no complications related to the exocrine pancreas. The pancreatic and renal grafts of these patients are functioning well 7, 3, and 2 months, respectively, after transplantation.

Adult↗
PubMed1982

Experience with a cooperative bone marrow transplantation program in Stockholm.

Twenty-seven patients (age range from 1 to 55 years) were included in a cooperative bone marrow transplantation program in Stockholm. Of eight patients with severe aplastic anemia (SAA), two died following graft rejection and six (75%) are alive between 3 months and 4 1/2 years after transplantation. Two patients with end stage leukemia died of septicemia and bleeding shortly after transplantation. Thirteen of 17 patients (76%) with acute leukemia in their first or second remission are alive 1 to 16 months after transplantation. Death was caused by septicemia in two patients, interstitial Candida pneumonitis in one and gastrointestinal bleeding in association with graft-versus-host disease in one. Among the leukemic patients all deaths occurred in subjects over 17 years of age and all 10 children are alive. No relapse has yet been seen. Successful bone marrow transplantations were carried out utilizing ordinary hospital resources only. This justifies the practice of performing transplantations in subjects with SAA and acute leukemia in remission even outside specially equipped and designed bone marrow transplantation units.

Acute Disease↗
PubMed1981

Atropine in mouse brain and plasma quantified by mass fragmentography.

A gas chromatography - mass spectrometric method has been developed for the assay of atropine in blood and brain tissue samples of mice. The method is based on the use of deuterium labelled atropine as internal standard and has a sensitivity allowing analyses of small brain structures, e.g. striatum and hippocampus. The method has been used to study the distribution and disposition of atropine in blood and brain of mice. The data obtained in blood can best be fitted by a two compartment open model with the elimination half-life of about 100 min., which was similar to that in brain. The concentration in brain structures with different cholinergic neuronal density was about the same.

Animals↗
PubMed1981

Further experience with antihuman lymphocyte globulin (Behring): no effect on cadaveric renal graft survival.

In 1977 we reported that 1 year cadaveric renal graft survival was improved in patients treated with high dose anti-human lymphocyte globulin (AHLG) (Behring). Such a beneficial effect of this agent was not confirmed in the present study with an enlarged series of patients and with a longer follow-up time. Nor was there any gain in respect of renal function or any steroid sparing effect. The only indication of an immunosuppressive effect is that the rejection episodes possibly occurred later in the patients given the high dose AHLG.

Antilymphocyte Serum↗
PubMed1981

The influence of HLA-D matching on the outcome of intrafamilial kidney transplantation with special emphasis on the predictive value of the relative response in MLC.

One hundred and three recipients of kidney transplants from living related donors were analyzed for the influence of HLA-D matching on graft survival. Sixty-two donors were parents and 41 brothers or sisters. Twenty-two of the siblings were HLA-A, B identical. The degree of HLA-D compatibility was measured in a mixed lymphocyte culture reaction. Whereas nonresponsiveness was found with HLA-A, B identical sibling donors, the haploidentical donors were found to initiate varying degrees of stimulation. The stimulation was, calculated as the relative response (RR) to the donor in relation to an unrelated individual or to lymphocytes pooled from a number of individuals. It was found that RR values above 55% predicted a graft survival that was significantly inferior to the group with values less than 20% (p less than 0.01) and also to the group with RR values between 20% and 55% (p less than 0.05).

Actuarial Analysis↗
PubMed1981

Reduced steroid doses in cadaveric renal transplantation.

Commencing 1978, we reduced the initial dose of prednisolone to 40 mg/day against a former 120-200 mg/day for cadaver kidney recipients aged 60 years and above. The patient and graft survivals at 1 year which earlier had been 59 and 47% is 69 and 46% after the change (NS). From August 1980, we reduced the initial prednisolone dose to 30 mg/day for all recipients of cadaver kidneys. From the same time, all patients were given 5 units of leukocyte poor blood prior to the transplantation, and in addition, RATG (Stanford) was given during 2 weeks immediately following the transplantation. Preceding the reduction the patient and graft survivals at 6 months were 91 and 62% while they were 88 and 88% after the reduction (NS). The intravenous dose of methylprednisolone, which is used for the treatment of acute rejection, was reduced twice in this period, first from 6 to 3 g, and then to 1.75 g total dose. The proportion of rejections, successfully treated, had remained unchanged. Our preliminary results support the notion that it is possible to use lower steroid doses than previously in conjunction with cadaveric kidney transplantations. However, we have introduced other alterations of the routines which could have influenced the results.

Animals↗
PubMed1981

Use of rabbit anti-human thymocyte globulin in cadaver kidney transplantation. Preliminary experiences.

Rabbit anti-human thymocyte globulin was given as an adjunctive immunosuppressive agent to 23 recipients of cadaver kidneys in the immediate 14 day post-transplantation period. A drastic reduction in the number of T-lymphocytes in the peripheral blood was recorded and there was a very low frequency (13%) of early, acute rejection episodes. Two to 8 months after transplantation 13 of 14 patients (93%) below 55 years of age survive with a functioning graft. Among 9 older recipients, the patient and graft survival was 56 and 33% and 4 of the patients died with septic complications. It is concluded that the elderly patients were over-immunosuppressed and we will no longer use RATG in this patient category.

Anaphylaxis↗
PubMed1981

A controlled trial with AHLG Behring: lack of effect on cadaveric renal graft survival.

To assess the effect of Pressimmune (AHLG-Behring), in high doses, (30 mg/kg/bdw for 21 days) as an adjuvant immunosuppressive drug a prospective, randomized controlled trial was carried out in 60 recipients of first time cadaveric renal allografts. There was no improvement in graft survival in the treatment group, and there was no steroid sparing. In the patients receiving Pressimmune, the T-lymphocyte count fell to about half pretransplant levels, and the first rejection episode occurred later than in the control patients, but eventually equally many kidneys were lost from rejection.

Adolescent↗
PubMed1981

Immunosuppression by Cyclosporin A in human renal transplant recipients.

Nine renal transplant recipients were treated with Cyclosporin A (CyA). Seven of them were high risk patients (diabetics or above 55 years of age) receiving cadaveric grafts. Two were recipients of related grafts and azathioprine had been shown to give them severe GI symptoms. Secondary anuria developed presumably due to nephrotoxicity caused by CyA in 2 of the recipients of cadaveric kidneys. The patients were converted to conventional immunosuppressive drugs and after 2-3 weeks, renal function had recovered in both patients. Seven patients have been maintained on a combination of CyA and oral prednisolone. Four of these patients experienced one or more rejection episodes, all were reversible on treatment with methylprednisolone. Two patients had episodes of increased serum creatinine due to nephrotoxicity by CyA. Recovery occurred when the dose was reduced. Other side effects observed were: Hirsutism (3 patients), gingival hyperplasia (1), tremor (2) and leukopenia (1). Four patients had infectious complications and one died of cytomegalovirus pneumonia. Six patients are well having serum creatinine levels ranging from 89-181 mumol/1, 1 to 11 months after transplantation.

Adolescent↗