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Biomedical subjects

G Lunardi

Publications and source records attributed to G Lunardi.

26 records · Page 2Linked to original sources
PubMed1991

Cholinergic modulation of [3H]dopamine release from dendrosomes of rat substantia nigra.

Dendrosomes prepared from substantia nigra are able to take up and release [3H]dopamine in a CA(2+)-dependent manner. The Vmax values of [3H]dopamine uptake in substantia nigra dendrosomes was about 5 times lower than that in caudate putamen synaptosomes. The pattern of the K(+)-dependency of the [3H]dopamine release in substantia nigra dendrosomes was significantly different from that found in caudate putamen synaptosomes. The release of [3H]dopamine evoked by 15 mmol/l KCl from superfused dendrosomes was increased in a concentration-dependent manner by acetylcholine. The maximal potentiation produced by acetylcholine was about 40%. The potentiation of [3H]dopamine release by 10 mumol/l acetylcholine was insensitive to mecamylamine but antagonized by atropine and by pirenzepine. The effects of acetylcholine on the release of [3H]acetylcholine from substantia nigra nerve endings was also studied. Exogenous acetylcholine added to the superfusion medium decreased in a concentration-dependent manner the release of acetylcholine. This effect was not antagonized by mecamylamine or pirenzepine but fully antagonized by atropine. The data suggest the existence, in the substantia nigra of the rat, of two distinct muscarinic receptor subtypes regulating respectively dopamine release from dopamine dendrites and acetylcholine release from cholinergic nerve terminals.

Acetylcholine↗
PubMedDate not supplied

[Support system for patient care planning and prescription for nursing care].

The use of information technology is reduced in health area. Its introduction as a management tool and decision support can change the actual kinds of planning within health organizations. The purpose of this work is to develop a system in order to enable and process the nursing prescription. The system named DSSPPNC-Decision Support System in Planning and Prescription of Nursing Care-is a computational tool that enables the information access under the form of Nursing Assistance Protocols. The results of the present work will involve sensible changes in the nursing assistential practice, with repercussion in the type of assistance management and to care the individual hospitalized, making opportune and approaching the nurse to the patient, through raising of problems, aiming care planning and accomplishment, results valuation and supervision and control of the staff engaged to in assistance.

Decision Support Techniques↗