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Biomedical subjects

G Lose

Publications and source records attributed to G Lose.

At least 91 records · Page 5Linked to original sources
PubMed1994

[Laparoscopic vaginal hysterectomy].

Laparoscopic assisted vaginal hysterectomy (LAVH) is a rather new operative procedure in Denmark. During the period 1.12.1992-28.02.1993 we performed ten LAVH. The procedure is described. The operations were performed with bipolar coagulation and subsequent cutting with scissors. The average operating time was two hours. The average uterine weight was 130 g and total average hospital stay was two 2.8 days. In one patient laparotomy had to be performed due to arterial bleeding close to the right ureter. One patient developed a postoperative haematoma with temporary stasis of the right ureter. Both patients recovered. Adequate laparoscopic training in humans and animals is mandatory before LAVH is performed. In the learning phase it is advisable that the uterine size does not exceed 200 g.

Adult↗
PubMed1994

Characterization of pressure changes in the lower urinary tract during coughing with special reference to the demands on the pressure recording equipment.

The exact demands on urodynamic equipment for measurement of coughs and cough associated pressure changes in the lower urinary tract have been analyzed from high-speed pressure recordings using a double microtip transducer and a storage oscilloscope. The equipment was tested in vitro by the step-test method. The natural frequency response was 175.6 Hz and the rise-time 2.5 ms, resulting in accurate measurements of frequencies up to about 60 Hz, which is way above the clinically measured frequencies. Four men and 2 women, all of whom were healthy volunteers, were examined in the supine position with an empty bladder. Pressures were measured in the bladder and in the external sphincter zone of the urethra. The spectral power density of the bladder and urethral pressures were calculated by Fourier analysis. The pressure changes in the urethra were in all volunteers equal to or slower than in the bladder. The analysis of the spectral power density showed that 99% of the pressure changes could be recorded with an instrument capable of recording 9 Hz frequencies, i.e., with a sampling rate of 18 Hz or more.

Adult↗
PubMed1994

The effect of pharmacological stimulation and blockade of autonomic receptors and of pudendal blockade on urethral stress relaxation in healthy women.

OBJECTIVE: To examine the influence of autonomic receptor stimulation and blockade (noradrenaline, prazosin, terbutaline, propranolol, carbachol and atropine), and of pudendal nerve blockade on urethral stress relaxation. SUBJECTS AND METHODS: Forty healthy women were evaluated. The stress relaxation parameter was defined as the relative rate of pressure decrease during a fixed period of time following a rapid dilatation of the urethra. The dilatation was performed by water-infusion into a small rubber cylinder placed in the urethra. RESULTS: The drugs did not affect stress relaxation significantly, whereas the pudendal blockade produced a significant change along the length of the urethra characterized by a faster pressure decay following dilatation. CONCLUSION: In women, stress relaxation in the urethra relies significantly on the pudendal nerve-innervated striated muscles.

Adult↗
PubMed1994

The effect of bilateral pudendal blockade on the adjunctive urethral closure forces in healthy females.

The effect of bilateral pudendal blockade on the urethral pressure and power generation during coughing and pelvic floor squeezing was evaluated in 10 healthy women. The measurements were carried out at the bladder neck, in the high pressure zone, and distally in the urethra before and after blockade. Strong adjunctive closure forces were demonstrated all along the urethra. They were significantly reduced by pudendal blockade except at the bladder neck during coughing. The results indicate that the pudendal innervated striated muscles contribute significantly to the adjunctively acting closure forces all along the female urethra, including the bladder neck. Some passive pressure transmission to the bladder neck seems to take place during stress episodes following pudendal blockade, but whether it occurs in healthy females remain uncertain. The findings following pudendal blockade, corroborate with those in stress incontinent women, and thereby support the concept that striated muscle weakness is of pathophysiological significance in stress urinary incontinence.

Adult↗
PubMed1994

Vesicovaginal fistulas: the transperitoneal repair revisited.

The experience in surgical repair of 18 complex vesicovaginal fistulas following abdominal hysterectomy is reviewed. The technique consisted in a transperitoneal approach and bivalving of the bladder. The fistulous tract was excised widely and the vagina closed transversely and the bladder longitudinally. In 10 patients, however, the bladder was closed in a Y-shaped fashion to avoid tension on the suture line. In 4 patients 5 ureters had to be reimplanted. There was one recurrence which was closed in a second attempt. For simple fistulas a simple vaginal approach is recommended. In complex fistulas including recurrences after vaginal repair a transperitoneal approach following the principles outlined will provide a high rate of success.

Adult↗
PubMed1993

The dynamic urethral sphincter function in healthy females assessed by rapid dilatations in the resting state: evaluation of reproducibility.

Recording the pressure response to rapid dilatations enables one to assess urethral sphincter function. The rapid dilatations of the urethra experimentally simulate the ingression of urine. A method that enables standardized dilatations of 2-mm long urethral segments was urine (USED).A method that enables standardized dilatations of 2-mm long urethral segments was used, and the subsequent pressure response was measured. The reproducibility of the urethral pressure response to rapid and standardized dilatations was evaluated by repeating the measurements after 1 week in 10 healthy females. The pressure response showed an acceptable reproducibility. The urethral pressure increase as a response to dilatation is considered to rely on stretching of intra- and periurethral fibers. Calculations of strain (change in length divided by the original length) of circularly arranged fibers when the urethra is dilated indicate that the tension (and pressure) bearing layers must be located outside a circular zone with a radius of 4 mm perpendicular to the longitudinal axis of the urethra.

Adult↗
PubMed1993

The influence of beta-adrenoceptor and muscarinic receptor agonists and antagonists on the static urethral closure function in healthy females.

The effects of terbutaline, propranolol, carbachol, and atropine on the static urethral closure function were investigated in 20 healthy women. Terbutaline caused a statistically reduction of the urethral pressure in the high pressure zone, but not at the bladder neck or in the distal urethra. The other drugs caused no significant pressure changes. None of the drugs used produced significant changes in the static viscoelastic properties, elastance, and hysteresis of the resting urethra. It is suggested that terbutaline partly reduces intraurethral pressure by reducing muscular tone in the rhabdosphincter and pelvic floor.

Adrenergic beta-Agonists↗
PubMed1993

The effect of pharmacological stimulation and blockade of autonomic receptors on the urethral pressure and power generation during coughing and squeezing of the pelvic floor in healthy females.

The effect of autonomic receptor agonists and antagonists on the urethral pressure and power generation during coughing and squeezing of the pelvic floor has been evaluated in 30 healthy females. The measurements were carried out at the bladder neck, in the high pressure zone, and distally in the urethra. The used drugs (noradrenaline, prazosin, terbutaline, propranolol, carbachol and atropine) caused no significant change in the pressure and power generation. The clinically relevant influence of drugs on the urethral closure function should be re-appraised when based on profilometry in the resting state. The results support that the effect of the autonomic nervous system on the urethral closure function is insignificant in healthy women. They furthermore indicate that investigations on the ability to secure continence cannot be based solely on resting pressure profilometry, but should be accomplished by measurements during stress episodes.

Adult↗
PubMed1993

Epidural anesthesia during labor and stress incontinence after delivery.

OBJECTIVE: To test the hypothesis that epidural anesthesia during labor prevents the development of stress incontinence after vaginal birth. METHODS: We interviewed 208 primiparas about stress incontinence 3 months postpartum. The women who developed stress incontinence after delivery were interviewed again 1 year postpartum. RESULTS: Twelve of 45 women (27%) who had epidural anesthesia developed stress incontinence de novo after vaginal delivery, versus 21 of 163 (13%) who did not receive epidural anesthesia, a marginally significant difference (P = .05). Those who had epidural anesthesia also had a significantly longer first stage of labor. One year after delivery, three of 42 (7%) in the epidural anesthesia group had stress incontinence, compared with five of 163 (3%) in the control group. CONCLUSION: Our results do not support the hypothesis that epidural anesthesia protects against the development of stress incontinence after vaginal delivery.

Adolescent↗
PubMed1992

[Hysteroscopically guided endometrial destruction in the treatment of menorrhagia].

Until recently, hysterectomy has been the alternative method of treatment in cases of premenopausal menorrhagia where it has not proved possible to obtain satisfactory regulation of the haemorrhage by medical means. Within recent years, a series of hysteroscopic methods have been developed for selective destruction of the endometrium by means of neodymium-laser, electroresection and coagulation. Compared with hysterectomy, hysteroscopic destruction of the endometrium appears to be a much more rapid, simpler and cheaper form of treatment of menorrhagia and appears to be associated with considerably fewer complications. The duration of hospitalization and the period of convalescence can be reduced considerably but, primarily, a large group of women can avoid hysterectomy. As yet, no controlled investigations of selective destruction of the endometrium as compared with conventional hysterectomy are available. There are no comparative investigations of the different methods nor of the long-term sequelae after destruction of the endometrium. This method of treatment has hitherto only been employed to a limited extent in Denmark. Coordination of the activities in this field in connection with establishing this form of treatment in Denmark should be encouraged.

Dilatation and Curettage↗
PubMed1992

Urethral pressure--which one?

Urethral pressure was investigated by a method which allowed simultaneous measurement of the cross-sectional area. In healthy women a pressure range of 25-140 cm H2O was recorded at one urethral site as a response to the circumstances under which the measurement was performed. The pressures obtained were related to the degree of urethral distension and to the time after the change in distension. Measuring urethral pressure at one specific degree of distension results in one specific pressure value according to the dimensions of the measuring probe. However, this specific pressure value cannot be considered to supply more information on urethral sphincter function than any other pressures included in a range which can be obtained by changing the circumstances under which the measurement are carried out. More provocative methods of pressure measurement which simulate some of the physiological conditions of the urethra may provide more information on sphincter efficiency.

Adult↗
PubMed1992

Pressure response to rapid dilation of resting urethra in healthy women.

Rapid urethral dilations were performed by a balloon mounted on a double-tip transducer catheter for simultaneous measurement of pressure in urethra and bladder. The cross sectional area of the urethra was measured according to the field gradient principle. Pressure and cross sectional area were recorded synchronously. The response of the female urethra to rapid dilation is a typical stress relaxation effect with a pressure peak followed by a pressure decay over a few seconds. The peak pressure response represents the bladder pressure required in producing a corresponding urethral dilation by the ingression of urine. The increase in pressure response was statistically significant by increasing rate as well as size of dilation. The method enables experimental simulation of stress urinary incontinence in vivo which may bring further insight into the physiology of the urethral closure function and the pathophysiology of stress incontinence. For comparative studies rapid dilation should be performed under standardized circumstances.

Adult↗
PubMed1992

Urethral stress relaxation phenomenon in healthy and stress incontinent women.

Urethral stress relaxation was induced by sudden forced dilatation. The stress relaxation parameter, Pt0.5, was defined as the relative pressure decrease 0.5 s after dilatation, where the pressures at 0.1 s and at the new equilibrium were set to 100% and 0% respectively. Pt0.5 was calculated in 28 healthy and 30 women with genuine stress incontinence. Measurements were performed at the bladder neck, in the high pressure zone and in the distal urethra. The measurements showed that all along the urethra, Pt0.5 was statistically significantly greater in the healthy women than in the incontinent women, the greatest difference being found at the bladder neck. Although there was a slight overlap in values between the 2 groups, this parameter seems useful in differentiating between competent and incompetent urethral sphincters.

Adult↗
PubMed1992

Initial urethral pressure increase during stress episodes in genuine stress incontinent women.

The urethral and bladder pressure increments registered during a cough were investigated in 30 woman with genuine stress incontinence (GSI) and compared with those from 30 previously investigated healthy women. The pressures were measured by means of a double microtip transducer catheter with the bladder sensor uncovered and the urethral sensor covered with a water-filled rubber cylinder and placed at the bladder neck, midurethrally, or distally in the urethra. In GSI women the pressure increment preceding the pressure spike produced by coughing was significantly higher in the bladder compared with the urethra, and the pressure increment seemed to be initiated in the bladder and all along the urethra simultaneously. In healthy women the pressure increment preceding a pressure spike was significantly higher in the midurethra compared with the bladder and it seemed to be initiated in the midurethra. These findings seem to reflect a defective active closure mechanism in GSI which may be a contributing factor in its pathogenesis.

Adult↗
PubMed1992

The effect of alpha-adrenoceptor stimulation and blockade on the static urethral sphincter function in healthy females.

The influence of noradrenaline and prazosin on the urethral closure function was evaluated in 10 healthy female volunteers. Measurements of pressure at varying cross sectional areas were carried out at the bladder neck, in the high pressure zone, and in the distal urethra. Prazosin reduced the static pressure, predominantly in the midportion of the urethra, whereas noradrenaline caused no significant pressure change. The urethral resistance to dilatation and the hysteresis were unaffected by the two agents. It is suggested that the response to prazosin is related to decreased activity of the urethral smooth as well as of the striated muscles, the latter as a result of a reduced somatomotor output from the central nervous system.

Adult↗
PubMed1992

The effect of bilateral pudendal blockade on the static urethral closure function in healthy females.

OBJECTIVE: To evaluate the effect of bilateral pudendal blockade on the urethral closure function in the resting state in healthy women. METHODS: Synchronous measurements of pressure and cross-sectional area were recorded at the bladder neck, in the high-pressure zone, and in the distal urethra before and after the pudendal blockade in ten women. RESULTS: The blockade reduced the resting pressure significantly (P < .01) all along the urethra. The viscoelastic indices of elastance (reciprocal of compliance) and hysteresis (difference in pressure at a given degree of urethral dilation when this is increased and decreased stepwise) were significantly (P < .05) reduced. CONCLUSIONS: The striated muscles innervated by the pudendal nerve are of paramount importance for the closure function in the resting state all along the urethra. Urethral elastance and hysteresis seem to depend on activity in the surrounding striated muscle fibers.

Adult↗