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Biomedical subjects

G Lorenz

Publications and source records attributed to G Lorenz.

At least 19 recordsLinked to original sources
PubMed1990

[Histotopographic studies of the intramural coronary arteries in the Trabecula septomarginalis of the right cardiac ventricle in swine (Sus scrofa domesticus) and dwarf goats (Capra aegagrus f. domestica)].

In the Trabecula septomarginalis (Moderator band) of pig and pygmy goat regularly till to 6 arteries are found, which traverse from the interventricular septum to the M. papillarius magnus. These intramural coronary arteries (diameter 50-300 microns)--without any exception-musculoelastic intimal thickenings are recognizable, which often marked extensive and formed in the whole vessel length. It is concluded that coronary arteries enlarge in response to increasing intimal thickening and that such enlargement can prevent narrowing of the lumen. The importance of the specificities in the wall structure of the arteries in the Trabecula septomarginalis are discussed as an adaptational reaction of the vascular wall to the extraordinary stress of these small vessels.

Animals↗
PubMed1990

[Histotopographic and morphometric studies of the intramural coronary arteries in the trabecula septomarginalis of swine and pigmy goats].

Up to six arteries traverse from the interventricular septum to the M. papillaris magnus in the trabecula septomarginalis (moderator band) of swine and pygmy goat. Musculo-elastic intimal thickenings, many of them quite extensive, are recordable from along the entire length of all these intramural coronary arteries which are between 50 microns and 300 microns in diameter. The conclusion may be drawn from the results of morphometric analysis that coronary arteries undergo enlargement in response to increased intimal thickening and that such enlargement does not lead to narrowing of the lumen. Peculiarities in wall structure of the arteries in the trabecula septomarginalis are interpreted as adaptive processes of the vascular wall to the extraordinary stress on those vessels.

Animals↗
PubMed1990

[Fibrous hamartoma in the infant].

Fibrous hamartoma is a rare example of juvenile fibromatoses. We report a case of an 11 month old infancy with presenting of clinical picture, morphological findings and therapy. Biological behaviour, differential diagnosis and pathogenetic connections to other fibromatoses were discussed.

Adipose Tissue↗
PubMed1990

Interaction of bacterial glucose-6-phosphate dehydrogenase with triazine dyes: a study by means of affinity partitioning and kinetic analysis.

The interaction of glucose-6-phosphate dehydrogenase (EC 1.1.1.49) from Pseudomonas W6 with 33 triazine dyes bound to poly(ethylene glycol) has been screened by means of affinity partition in an aqueous two-phase system composed of poly-(ethylene glycol) and dextran. Regarding the strength of interaction expressed by the affinity partitioning effect three groups of dyes can be distinguished showing high, medium or low interaction to the enzyme. The different influence of the structurally related dyes Cibacronblue F3G-A, Procion Blue MX-3G and Procion Blue MX-R on the partitioning of glucose-6-phosphate dehydrogenase is discussed. Both coenzymes of this glucose-6-phosphate dehydrogenase, NADP+ and NAD+, are able to diminish the dye-enzyme interactions but to a different extent. In the case of Procion Red HE-3B less than 0.2 mM of NADP+ abolished completely the dye-protein interaction indicating that the dye binding site might be closely related to the nucleotide binding site. This does not hold for a series of other dyes revealing strong interactions to the enzyme. In these cases higher NADP(+)-concentrations are necessary to weaken the dye-enzyme interactions. Only small influences on the interaction between the dye and glucose-6-phosphate dehydrogenase were found with 1 mM NAD+. The different effects of the two coenzymes are discussed with respect to separate binding sites for them and to different conformational states induced. The competition of Procion Red HE-3B with NADP+ and NAD+ for the binding site of glucose-6-phosphate dehydrogenase was also demonstrated by inhibition studies. The Ki-values of Procion Red HE-3B with NAD+ and NADP+, respectively, were calculated.

Bacterial Proteins↗
PubMed1989

[Correlative morphological studies of the heart of guinea pigs].

Investigations were conducted to record the following morphological parameters from hearts of guinea pigs (alb/Jena, inbred strain): absolute and relative heart weight as well as weights of left and right ventricles and of the interventricular septum. Correlations are described and discussed between the values recorded as well as between those values and body weight and changes in the course of ageing. The point is made that investigations of this kind are helpful in describing heart development in its totality and may provide better prerequisites for appraisal of pathological conditions.

Aging↗
PubMed1989

[Quantitative morphology of the intramural coronary arteries of the trabecula septomarginalis of pigmy goats and swine].

There are musculo-elastic intimal thickenings in the intramural coronary arteries of the Trabecula septomarginalis, which results in a stenosing grade of 69% in average in 6 month old pigs, of 43% in 1-6 months old pygmy goats and of 35% in average in 4-7 years old pygmy goats. The degree of intimal thickenings is related to the arterial diameter (r = -0.60); the strongest of which are found in small vessels of 100-200 microns. With increasing arterial diameter during ageing the stenoses decrease. The role of the intramural coronaries of the Trabecula septomarginalis is discussed.

Animals↗
PubMed1989

[Clinico-pathology of salivary gland tumors of the head in children and adolescents].

Tumours of salivary glands are rare in childhood and adolescence. Our material consists of 10 observations. The principles of classification of these tumours and the differences to the adults are reviewed. Nonepithelial tumours are diagnosed in a higher percentage in the first two decades of life. Epithelial neoplasms are often connected with doubtful or malignant behaviour.

Adolescent↗
PubMed1989

[Light microscopic studies of the intramural coronary arteries in the trabecula septomarginalis of the right heart ventricle of cattle, swine and dwarf goats].

In the Trabecula septomarginalis (moderator band) of cattle, pig and pygmy goat regularly till to 6 arteries are found, which traverse from the interventricular septum to the M. papillaris magnus. At these intramural coronary arteries (diameter 100-800 microns)--without any exception--musculoelastic intimal thickenings are recognizable, which often may result in concentric luminal narrowings of a high degree. The genesis and importance of the specificities in the wall structure of the moderator band arteries are discussed in relation to the intramural coronary arteries of the ventricular wall and papillary muscle as an adaptational reaction of the vascular wall to the extraordinary stress of these small vessels.

Animals↗
PubMed1988

[The Schloffer tumor. Morphology and clinical aspects of 3 cases].

Three cases of the so-called Schloffer tumour are presented. It is a rare inflammatory pseudotumour of the abdominal wall with aggressive connective tissue proliferation which frequently infiltrates neighbouring abdominal organs. Usually this tumour occurs several years after abdominal surgery or trauma, thus posing substantial problems in the interpretation of the clinical and morphological findings. In one of our male patients for instance, a sarcoma of the abdominal wall was suspected pre- and intraoperatively. A female patient was falsely considered to have a carcinoma of the urinary bladder. The lesion belongs to the reactive tumour-like fibromatoses and has to be distinguished from genuine soft tissue tumours, especially the abdominal desmoid.

Abdominal Muscles↗
PubMed1988

[Histological grading of neuroblastomas. 25 cases].

Histological studies were conducted into 25 cases of neuroblastoma selected from consecutive biopsy material. They were 4 grade I, 5 grade II and 16 grade III tumours, according to the classification of Hughes et al. Two of the grade I neuroblastomas exhibited diffuse growth patterns. The other two were diagnosed as composite types. The histological signs of differentiation and their prognostic value are discussed.

Child↗
PubMed1988

[Ileus of the small intestine caused by intestinal anisakiasis (herring worm disease)].

Two cases of anisaciasis caused by eating of improperly prepared herrings which were infested with larval nematodes are reported. The acute type with a stenosing process in the small intestinal wall existed in both cases which resulted in an ileus. Therapy was resection of the affected intestinal part with end-to-end-anastomosis. The morphological proof of larval nematodes, which penetrate from lumen into the eosinophilic granulomata, pseudotumours and eosinophilic microabscesses are important histological findings. It should be considered the possibility of a herring worm disease in the case of an acute abdomen caused by an inflammatory small bowel stenosis.

Adult↗
PubMed1988

[Intrathoracic gastric duplication with intrapulmonary abscesses and perforation into the bronchial system--pathologico-anatomic peculiarities and diagnostic problems].

Gastric and enteric cysts represent genuine duplications. With regard to their genesis opinions are divided. These duplications may perforate into the lung parenchyma and/or the bronchial system, giving rise to specific symptoms. The only possible therapy is complete extirpation. The intrapulmonary metastases are drained and aspirated and can be cured without loss of lung tissue. A report is given on a thoracic cystic gastric duplication with haemorrhagic inflammation of the mucous membrane associated with erosions in a 8-week old boy. Clinically, the duplication was reflected by poor general health, dyspnea and tachypnea. The perforation into the bronchial system caused respiratory insufficiency. Using antibiotic therapy, immune substitution and surgery in combination, the boy was cured. The morphological findings, causative embryological factors, and diagnostic possibilities and problems are discussed.

Bronchi↗