Biomedical subjects

G Loas

Publications and source records attributed to G Loas.

79 records · Page 5Linked to original sources

PubMedDate not supplied

[A four-dimensional model of chronic schizophrenia based on the factorial structure of the Positive and Negative Syndrome Scale (PANSS). A study of a group of 153 chronic schizophrenic patients and comparison with the factorial structure of the BPRS].

The aim of the study is to explore the latent dimensions in chronic schizophrenia using factorial analysis methods. 153 subjects (89 males, 64 females) with a mean age of 38.83 years (sd = 10.15) meet the RDC criteria for chronic schizophrenia and were included in the study. They were 127 inpatients and 26 outpatients and the mean duration of the illness since the first psychotic episode was 14.69 years (sd = 9.64). The majority of the schizophrenics received antipsychotic treatment with a mean dose (in chlorpromazine-equivalent) of 401.86 mg (sd = 368.13). The schizophrenics were rated using the French versions of the Positive and Negative Syndrome Scale (PANSS) and the Brief Psychiatric Rating Scale (BPRS). Two successive principal components analyses (PCA) were carried out on the correlation matrix of the 30 PANSS and 18 BPRS items. The numbers of factors were limited using several guidelines : eigenvalues higher than 1, screen test and the parallel analysis of Horn. Then an orthogonal equamax rotation was made and the saturation value was chosen using and ad-hoc paradigm. The results have shown a four-factors solution for the PANSS with the following factors : negative, positive-hostility, disorganization-impulsivity, depressive-anxious. The composition of the four preceding factors was respectively : negative [N1, N2, N3, N4, N6, N7, G7, P4 (-)]; positive-hostility (P1, P2, P3, P5, P6, P7, G8, G9, G12, G15, G16); disorganization-impulsivity (G5, G10, G11, G13, G14, N5); depressive-anxious (G1, G2, G3, G4, G6). The ACP of the BPRS have shown a three factors solution (positive-disorganization, negative, depressive-anxious). The factorial structure of the PANSS was discussed with the different studies. Our results confirm the division of the productive symptomatology into two components, delusions-hallucinations and cognitive (disorganization). Moreover depressive and negative symptomatology constitute two separate dimensions. Contrary to the others studies we did not find an excited component, the corresponding items were found in the positive and disorganization factors. The inclusion of solely chronic schizophrenics could explain the lack of the excited component. Our data in chronic schizophrenia allow us to propose a four-dimensional model explaining the symptomatology of this disease.

Adult↗

PubMedDate not supplied

[Capacity to experience pleasure and displeasure by Cloninger and von Knorring in type I and II alcoholism].

The aim of the present study is to test the hypothesis that Cloninger and von Knorring's type II alcoholics are more hedonic and experience less displeasure than type I alcoholics. 55 inpatients filled out the DSM III-R criteria for abuse or alcoholic dependence. The alcoholics were dichotomized into type I or type II using the onset of their alcoholism (type II < 25 years, type I > or = 25 years). In the few days of their hospitalization, the subjects filled out the Fawcett Clark Pleasure Capacity Scale-Physical Pleasure (FCPCS-PP), the Hardy Displeasure Capacity Scale-Physical Displeasure (HDCS-PD) and the abridged form of the Beck Depression inventory (BDI). The sociodemographic characteristics, the proportions of "abusers" and "dependents" and the scales scores were compared between the two groups. The sex-ratio and the educative level were not different between the two groups; the values of the chi 2 were respectively 1.36 (df = 1), p = 0.24 and 1.03 (df = 2), p = 0.59. The ratio "abusers" /"dependents" was not different (chi 2 = 1.115, p = 0.291). The mean age of the type I alcoholics was higher (m = 46.7, sd = 11.2) than that of the type II (m = 38.9, sd = 7.9) (U = 218.5, p = 0.013). Using covariance analyses (ANCOVA) to control the age, the results have shown that the FCPCS-PP and HDCS-PD scores of the type II alcoholics were not different than these of the type I alcoholics [respectively F (1.52) = 1.5, p = 0.23 and F (1.52) = 0.14, p = 0.7]. In conclusion, we failed to confirm the hypothesis that type II alcoholics would experience more pleasure and less displeasure than type I alcoholics. These negative results were discussed and the potential factors that could explain them are detailed.

Adult↗

PubMedDate not supplied

[French translation of the Frankfurt Complaint Questionnaire (Frankfurter Beschwerde-Fragebogen, FBF, Süllwold, 1986)].

Observable behaviors play the predominant role in the clinical assessment of schizophrenia, while only secondary emphasis is placed on exclusively subjective complaints. Huber employed the phenomenological approach to obtain subjective symptoms that he named "basic symptoms". Subjective symptoms constitute an important component of the schizophrenic symptomatology. They may play a predominant role during the prodromal or early phases of the disease, they may be useful in elucidating cognitive and perceptual disturbances in schizophrenia. In the last decade, the assessment of patients' subjective experiences has acquired significance with the development of several instruments for their specific evaluation. The Frankfurt Complaint Questionnaire (FCQ, Süllwold, 1986) is the instrument most widely used in Europe for assessing subjective experiences. It covers a wide range of complaints of cognitive deficits that Süllwold compiled from the complaints of schizophrenic patients. We present the French translation of the FCQ. The availability of the FCQ in French could be an important step in promoting the study of subjective experiences in research and clinical activities.

Adaptation, Psychological↗

PubMedDate not supplied

[Validation of the French version of the Snaith-Hamilton Pleasure Scale (SHAPS, Snaith et al. 1995). Determination of the statistical parameters in 208 normal subjects and 103 hospitalized patients presenting with depression or schizophrenia].

The aim of the study is to explore the validity and the reliability of the French version of the SHAPS in two groups of subjects. 208 healthy students and 103 inpatients meeting the RDC criteria for schizophrenia or depression filled out the French versions of the SHAPS and the revised Physical Anhedonia Scale of Chapman and Chapman. The internal consistency of the SHAPS was measured in each group using first the Kuder Richardson coefficient (point biserial) between the items and the total score. The concurrent validity was studied using the Pearson correlation coefficient between the SHAPS and the PAS in each group. The predictive validity was determined by the comparison of the SHAPS score between the two groups. The reliability was studied using a test-retest in a sub-group (n = 32) extracted of the control group. The values of the KR 20 in the healthy and psychiatric groups were respectively 0.47 and 0.80. The mean of the correlations between the items and the total score were respectively 0.35 and 0.52. The values of the correlations between the SHAPS and the PAS were respectively in the normal and psychiatric groups 0.39 (p < 0.001) and 0.34 (p < 0.001). Psychiatric subjects had a higher score (m = 2.33, sd = 2.68) on the SHAPS than the normals (m = 0.89, sd = 1.18) [F (1,303) = 12.26, p = 0.0005]. The test-retest showed a correlation of 0.56 (p < 0.01) between the two passations of the SHAPS. The metrological parameters of the SHAPS were discussed as well as the utility of that scale compared to the PAS.

Adult↗

PubMedDate not supplied

[Validation of the French version of the revised Personal Style Inventory (revised Personal Style Inventory, PSI-II, Robins et al., 1994)].

The aim of the present study is to determine the validity and reliability of the French version of the PSI-II. The PSI-II is a self-rating scale divided into two subscales containing each 24 items and rating sociotropy and autonomy. 202 university students (170 females, 32 males) with a mean age of 21.54 years (sd = 4.16) were included. They filled out the PSI-II and the Interpersonal Dependency Inventory (IDI). The construct validity was explored using an exploratory principal components analysis followed by an orthogonal varimax rotation. The results had shown a three-factor solution with a "sociotropy" factor and two "autonomy" factors. The Cronbach alpha coefficients were respectively 0.83 and 0.72 for the sociotropy and autonomy subscales. The Pearson correlations between the PSI-II and IDI subscales showed significant correlation first between the sociotropy subscale and the two subscales of the IDI rating dependency, the values were respectively 0.67 (p < 0.001) and 0.44 (p < 0.001), and secondly between the autonomy subscales of the PSI-II and IDI, the value was 0.39 (p < 0.001). The sociotropy subscale items correlated significantly with the total score of the subscale with a mean of 0.46. 23 items of the autonomy subscale correlated with the total score with a mean of 0.36. The sociotropy and autonomy scores were respectively 93.98 (sd = 14.22) and 84.55 (sd = 11.69). The French version of the PSI-II had satisfactory metrological parameters and allows to study sociotropy and autonomy in French population.

Adolescent↗

PubMedDate not supplied

[Subjective Experience of Deficits Scale in schizophrenic patients].

The aim of the study is to present the French version of the scale for the assessment of subjective experiences of deficits in schizophrenia (SEDS, Liddle and Barnes, 1988). The metrological parameters of the French version of the SEDS were studied in 50 RDC chronic schizophrenics. The interraters reliability was determined using the Kappa and Kendall coefficients of concordance. Among the 50 schizophrenics 30 filled out once again one month later the French version of the SEDS and the temporal stability of each scale's item was calculated using frequency (%). The construct validity was determined using first the Cronbach alpha coefficient and secondly by calculating the Pearson correlation coefficient between each item and the total score. The Kappa coefficients were higher than 0.4 for 15 items out of 22. The Cronbach value was 0.87 19 items out of 22 had a temporal stability from 64.2% to 100%. Thus the French version of the SEDS seems to be reliable and could allow to study subjective experiences of deficits in schizophrenia.

Adult↗

PubMedDate not supplied

[Polydipsia: review of the literature].

Polydipsia, unrelated to organic polyuria is present in 20% of the patients hospitalised in psychiatry on a long term basis. It seems that about a third of them have presented at some point an episode of water intoxication. Most patients with psychogenic polydipsia excrete all the water they absorb. In a subgroup of them, at risk for water intoxication, the capacity to excrete water is deficient. This is usually due to an inappropriate secretion of antidiuretic hormone. The first two steps in the treatment of patients with psychogenic polydipsia consist in making the diagnosis and in evaluating the risk of water intoxication. To do this, one must monitor throughout the day their weight and the serum sodium plasma level if necessary, then reduce the risk factors and prescribe water restriction during the high risk periods. Behavioural therapy is sometimes used; prospects for chemotherapy are being studied. It is probable that there is not a single type of patient with psychogenic polydipsia but several subtypes, the etiology being multifactorial.

Drinking↗