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Biomedical subjects

G Lo Russo

Publications and source records attributed to G Lo Russo.

At least 37 records · Page 2Linked to original sources
PubMed1997

[Malignant tumors of the peripheral nerve sheath (MPNST) after irradiation].

A case of relapsed malignant tumor of the brachial plexus and its nervous roots (MPNST) was observed in a patient treated with radiotherapy for Hodgkin's disease 24 years previously. A known risk of radiation therapy is the induction of secondary neoplasms, less commonly malignant peripheral nerve sheath tumor (MPNST). The clinico-pathological features of this rare tumor are presented and the possible relationship between radiotherapy and MPNST is discussed.

Adolescent↗
PubMed1996

[Temporal lobe epilepsy: stereotaxic methods].

We give a description of stereotaxic methodology as originally elaborated by the S.te Anne Hospital School in Paris, and successively modified and utilised in Niguarda Hospital in Milan. Performing a stereotactic arteriography and ventriculography should allow the appreciation of minimal modification of vascular anatomy, identification of sulci and gyri by utilising stereoscopic technique and the proportional grid, based on bicommissural line, evaluation of the morphological abnormalities and their precise reconstruction in the intracranial space. Anatomical information obtained by this kind of examinations are essential for intracerebral stereo-EEG investigation and for planning surgical procedure.

Brain Mapping↗
PubMed1996

[Relationship between anatomic lesions of the temporal lobe and temporal lobe epilepsy].

A structural lesion of the brain is a frequent finding in intractable partial epileptic patients. We analyse anatomo-electro-clinical characteristics of 58 patients in which MR showed a lesion inside the temporal lobe. They are 29 males and 29 females with a mean age at surgery of 23.5 +/- 10.7 years (2.6-45.9). The mean epilepsy duration is of 13.4 +/- 8 years (1.3-35.5), with a mean seizure frequency of 28.7 +/- 43.6 per month, with a great inter-individual variability (from 3 per month to 15 a day). The minimum follow-up is 3.5 years. A video-EEG monitoring was performed in 21 cases, while a stereo-EEG investigation was judged mandatory in 26. On the basis of anatomo-electro-clinical correlations and of the results of presurgical investigations, the epileptogenic area was proved to be temporal in 49 cases, temporal but controlateral to the lesion in 1, and at least bilobar in 8 patients.

Adolescent↗
PubMed1996

[Short account of modern history of surgery in temporal lobe epilepsy].

We make an overview of the most significant historical steps of the temporal lobe epilepsies surgical treatment, from the first description, at the end of 19th century, to recent times. We also describe the history of neuropsichological testing (mainly Wada test), extra- and intra-cranial EEG-recordings, synchronised electro-clinical monitoring, structural and functional neuroimaging. We mainly tried to point out that the selection of candidates to surgical treatment should be based, despite any technological development, on a synoptical anatomo-electroclinical reasoning.

Diagnostic Imaging↗
PubMed1996

[Surgical treatment of temporal lobe epilepsy: reality and prospectives].

This chapter provides a synthetic overview of the topics treated in this issue. Presurgical diagnostic procedures are schematically described and an analysis of surgical results is made in comparison with those obtained from other epilepsy surgery groups. Surgical complications linked both to invasive presurgical diagnostic procedures and therapeutic surgical acts are described. Finally, the creation of new epilepsy surgery centres is suggested on the basis of epidemiological data, which demonstrate the discrepancy among the patients operated on at present and those who could benefit from the surgical treatment.

Decision Making↗
PubMed1994

Stereo-electroencephalography methodology: advantages and limits.

Since January 1990, 70 patients with medically intractable partial epilepsy underwent a stereo-EEG investigation in our center. We first described technical requirements, and gave an overview of the variety of the explored cerebral regions and implantation patterns realized, pointing out the low rate of morbidity (1.4%). The three-dimensional epileptogenic zone thus defined led to a tailored individualized surgical excision in 60 patients, while 9 are waiting for surgery and the remaining 1 has been excluded (1.4%). Conceptual and technical aspects of the stereo-EEG methodology were discussed in order to underline its peculiarities in the field of "depth recordings", and more generally among the broader group of "invasive" procedures.

Adolescent↗
PubMed1993

Intracerebral low frequency electrical stimulation: a new tool for the definition of the "epileptogenic area"?

Low Frequency (1 Hz) Electrical Stimulation (LFES) has been systematically utilized, during stereo-EEG investigations, in 24 consecutive young adult patients considered for surgical treatment of severe drug-resistant partial epilepsy. Ninety seizures (1-14/patient) identical to the spontaneous ones previously recorded were thus obtained in 19 patients (79%). LFES is less effective for induction of seizures than high frequency (50 Hz) stimulation (5.9% vs 22.9%), and it also provokes less "false positive" responses (1% vs 17%). The main "sensitive" structures to LFES are the hippocampus, the amygdala, and the hippocampal gyrus. However, seizures were also induced by stimulating the temporal lobe white matter, the temporal pole, and the temporal neocortex, as well as the orbito-frontal cortex (in the only patient with fronto-temporal epilepsy). The more frequently observed electrical pattern is a gradual increase of spikes and spikes and waves frequency, with or without occurrence of low voltage fast activity. The high percentage of early "subjective" manifestations similar to the spontaneous ones, the lack of major electrical artifact, and the good visualization of the spatial evolution of the induced-discharge, strongly suggest that LFES is of great help for defining the "epileptogenic area".

Adult↗
PubMed1993

[Electroclinical manifestations elicited by intracerebral electric stimulation "shocks" in temporal lobe epilepsy].

In patients with severe drug-resistant partial epilepsy, undergoing Stereo-EEG investigations, spatial definition of the "epileptogenic area" is mainly based on spontaneous seizures recordings, but also on seizures induced by intracerebral electrical stimulation (ES). Only "trains" ES (TES, 50 pps) are currently used with this aim; "shocks" ES (SES, 1 pps) are principally applied to localize motor pathways. We have shown, during a prospective study concerning 10 temporal lobe epileptic patients, that SES could frequently induce seizures, especially when stimulation is applied in the anterior part of the Ammon's horn. Even if its efficacy seems lower than by TES, this kind of stimulation, in the majority of the cases, does reproduce isolated ictal subjective symptomatology, allowing the visualization of the progressive organisation of ictal electrical discharges, and avoids "unexpected" ("false positive"?) clinical responses.

Adolescent↗
PubMed1992

Stereotactic approach to intracranial lesions.

The diagnostic and therapeutic approach to intracranial lesions must be different considering the different possibilities offered by the various methods. The diagnostic reliability and safety of stereotactic biopsy are often indispensable in order to optimize the subsequent therapy. The results obtained in selected pathologies allow us to propose the stereotactic approach to treat: -various kind of cysts by aspiration and/or Beta endocavitary radiation therapy; -blood or abscessual collections that can be aspirated in a similar way; -arterio venous malformations or tumours by radiosurgery; -tumours by brachicurietherapy or by computer assisted stereotactic surgery. We present some cases treated at the C.H.S.A. of Paris and at the C.H.R.U. of Grenoble utilizing Talairach methodology.

Adolescent↗
PubMed1981

The radiologic "Target sign" of septic pulmonary embolism in a case of acute myelogenous leukemia.

The authors report the appearance of septic pulmonary embolism in a case of acute myelogenous leukemia. The pulmonary lesions are characterized radiographically by the uncommon appearance of central densities suspended within thin-walled pseudocystic air spaces. A possible pathogenic mechanism explaining these radiographic findings is discussed. Such images must be distinguished from those of a fungus ball or tuberculous cavities.

Adolescent↗
PubMed1980

[Controlled hypotension with nitroglycerin in neurosurgery (author's transl)].

Controlled hypotension with nitroglycerin has been used n 30 neurosurgical procedures for aneurysms clipping, artero-veinous malformations, cerebral vascularised tumours and in some cases in the course of serial carotido-cerebral angiography. Farmacodynamic aspects of this drug and its effects on intracranial pressure are compared with sodium nitroprusside. Controlled hypotension was induced with prepared solution of nitroglycerin via an infusion pump in order to achieve a mean arterial blood pressure from 70 to 40 torr. All patients during hypotension were monitored by continuous blood pressure, pulse rate and intracranial pressure records. First results of our clinical evaluation indicate that this drug produce a rapid fall in blood pressure without harmful effect and does not significantly modify intracranial pressure. Its potential benefit in spasm of intracranial arteries associated with subarachnoid bleeding is investigated.

Adult↗