[Relation between antioxidation and immunoregulation of bilirubin].
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Adjuvants, Immunologic↗
Biomedical subjects
G Liu
Publications and source records attributed to G Liu.
Predictive value of clinic blood pressure variability for pressure changes during placebo in elderly hypertensives.
OBJECTIVES: Syst-China is the ongoing placebo-controlled double-blind outcome trial in older (aged 60 years or more) Chinese patients with isolated systolic hypertension (systolic blood pressure 160-219 mmHg and diastolic blood pressure < 95 mmHg). This article is based on the data accumulated until 31 August 1992. Its purpose is to investigate the extent to which the variability in the clinic blood pressure readings at baseline could predict the blood pressure changes observed in the placebo arm of the trial. METHODS: From 2379 patients recruited into the trial, 728 [455 men and 273 women, aged 66.7+/-5.5 years (mean +/- SD)] were selected, because their blood pressure readings for the three run-in visits as well as 3, 6 and 12 months after random allocation were available. Overall and between-visit blood pressure variabilities at baseline were estimated from the two readings obtained with the subject seated during the first and second run-in visits. The baseline blood pressure used to calculate the blood pressure changes during follow-up was the average of the two readings during the third run-in visit. RESULTS: The blood pressure variability at baseline was larger for women than it was for men. For all of the subjects combined, the blood pressure had decreased by 4.1+/-14.4 mmHg (P < 0.001) systolic and 0.5+/-6.7 mmHg (P < 0.06) diastolic by the 3-month follow-up visit, by 8.5+/- 15.2 and 1.4+/-7.5 mmHg, respectively, after 6 months and by 10.3+/-15.7 and 1.9+/-7.9 mmHg, respectively, after 1 year (p < 0.001 for all). Stepwise multiple regression analysis showed that sex, age, alcohol intake and the blood pressure at baseline were significant determinants of the long-term (1 year) blood pressure changes. Aftger adjustment for the aforementioned covariates, the between-visit variability was a significant predictor of the changes in the diastolic blood pressure after 1 year of placebo treatment for the men (partial r+/-SEM -0.36+/-0.12, P < 0.01) and for all of the subjects (-0.19+/-0.09, P < 0.05). For men, the partial regression coefficient between the overall variability and the changes in the diastolic blood pressure also attained statistical significance (-0.39+/- 0.14, P < 0.01). CONCLUSION: For older Chinese patients with isolated systolic hypertension, in particular for men, a higher blood pressure variability at baseline was associated with a larger decrease in diastolic blood pressure during 1-year follow-up on placebo, explaining up to 2% of the variance of the observed changes. Similar associations were not observed for systolic blood pressure.
Journal Article↗
[A simple, rapid method to isolate cardiac myocytes from rat and guinea-pig].
A simple, rapid method to isolate cardiac myocytes from rat and guinea-pig was described by using this method. Morphologically intact and calcium tolerant single myocytes were obtained. The myocytes were suited well for various electrophysiological recording especially in patch clamp study.
Animals↗
[The relationship between environmental concentration and exposure concentration in the airborne dust of workplace].
The authors studied the relationship between environmental concentration and exposure concentration in the airborne dust of workplaces, using instantaneous fixed points sampling and personal wear sampling. The results showed that there was a correlation between two kinds of concentrations in the automatic and man-made packing workplaces (r = 0.9914, 0.9977). A relationship between them in the unsteady workplace was found after analysed by one-accumulated generating operation (1-AGO) (r = 0.9945). The samples of environmental and exposure concentrations could be thought from the same normal distribution, that is, the bivariable random sampling in the normal distribution population. Moreover, the exposure concentration could be estimated by environmental one after 1-AGO in the unsteady workplace of airborne dust.
Air Pollutants, Occupational↗
[Research on types of Salmonella in some animals in Jilin province].
Some animals were examined for the presence of Salmonella in Jilin province. The rate of Salmonella detection was 537 strains from 846 snakes samples (63.5%); 136 strains from 648 frog samples (20%); 185 strains from 369 pig and chick samples (50%). All isolated Salmonella comprised of two subgenus (SII and SIIIb). Serologically, groups 04, 07, 08, 09, 01, 03, 19, 03, 10, 016, 035, 043, 048, 050, 058 and 061 were identified and the isolates were classified into 13 groups and 24 serotypes. Two of these isolates SII43:enZ15:1, 6 and SIIIb58:Z52:Z are reported for the first time in China.
Animals↗
[Experimental study on the influence of sodium glutamate on embryonal brain development of mouse].
The main component of gourment powder is a typical excitatory amino acid. Its neurotoxic action has been attended extensively. Healthy Kunming strain mice were used in this study. Sodium glutamate was injected into peritoneal cavity from the fourth day of gestation (at dosages of 60, 30 or 10 mg/kg every other day). The embryonal mice were dissected at the eighteenth day of gestation. The brain of embryonal mouse was removed, weighted, and fixed in Carnory's solution. Routine paraffin section was made. HE, Feulgen and Nissl staining methods were used for morphological observation. The ash values of 100 neurons of cerebral cortex of Feulgen and Nissl staining were randomly measured with an automated image analyser. The results showed that there was no morphological change in the experimental and control group. There was no significant differece between experimental groups and control group in the parameters observed (P > 0.05). It was suggested that sodium glutamate was not harmful to embryonal brain development of mouse.
Animals↗
[Some problems in the therapy of hypertension].
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Adrenergic beta-Antagonists↗
[Effect of antihypertensive agents on plasma endothelin, nitric oxide and so on in essential hypertension].
Ninty patients with mild to moderate essential hypertension (EH) were randomly divided into three groups and treated with Enalapril (E), Metoprolol (M) and Nifedipine (N) respectively. After a six-week-treatment, SBP and DBP of each of the three groups decreased significantly (vs. pre-treatment, P < 0.001). Plasma concentration of ET, NO, cGAMP and MDA in group M remained unchanged, and that of MDA in group N, especially of the stage II EH, decreased remarkably (vs. pretreatment, P < 0.05; vs. that of stage I EH, P < 0.05). While that of ET, NO, cGMP, and MDA in group E changed significantly (vs. Pretreatment, P < 0.01) and that of ET and MDA of stage II EH in group E exhibited more remarkable changes (vs. that of stage I, P < 0.05). It is suggested that E, and at some degree N, may protect the vascular endothelium from being damaged in EH, and also may contribute to prevent EH from development.
Adrenergic beta-Antagonists↗
[Analysis of severe fire disaster in five years (1989-1993) in China].
UNLABELLED: The aim of this study was to analyze epidemiological characteristics of burn caused by severe fire disaster. The results of this study showed that a total 21,228 people were burned, 10,428 cases died and RMB 3320 millions yuan were lost in those fire disasters occurring in five years (from 1989 to 1993) in this country. The principal causes of the fire disaster were faults in administration and operations against regulations. CONCLUSION: In order to prevent fire disaster propaganda should be carried out, jurisdiction should be enforced, active "law of fire control" and the program of constructive administration should be implemented. Those who are working in burn care should also participate in work of fire control and devote much attention to the investigation of burn epidemiology.
Burns↗
[Construction of human genomic YAC clones with "terminal modification"].
A human YAC genomic pool with more than 4,000 clones was constructed by means of "terminal modification" of YAC vector and genomic inserts, as well as optimization of relevant experimental parameters. The transformation rate is approximately 400-500 transformants per microgram DNA. Preliminary characterization of randomly sampled clones demonstrates that YAC-specific inserts, in the average size of 450 kb and ranging 150-750 kb, were detected from 80% of the clones. The vector ligation experiment indicates the efficient reduction of "coligation" by terminal modification.
Chromosomes, Artificial, Yeast↗
[The frequencies of the vitamin D receptor gene alleles in adults of Han nationality in Beijing area].
Vitamin D receptor (VDR) gene is considered as one of candidate genes related to the genetic basis of bone and mineral metabolism. In order to determine VDR genotypes, we analysed the polymorphisms, or genotypes of Bsm I, Apa I, and Taq I restriction enzymes, by PCR technique in 223 unrelated healthy adults of Han nationality in Beijing area. Some of the VDR genotypes were also confirmed by Southern blotting analysis. We discovered that Chinese had high frequencies of b, a, T alleles, as high as 95%, 75%, and 95% respectively, which were different from those in Caucasians and Japanese, but similar to those in Koreans (P > 0.05). This difference gave us further insight into the different pathogeny of osteoporosis in various ethnics.
Adult↗
[The association between vitamin D receptor gene polymorphisms, bone mineral density and osteocalcin in Chinese women].
OBJECTIVE: To investigate the correlations between vitamin D receptor (VDR) gene polymorphisms, and bone mineral density (BMD) as well as osteocalcin. METHODS: We used PCR-RFLP and Southern hybridization analysis to determine VDR genotypes in 202 Chinese women. BMD was measured by dual-energy X-ray absorptiometry (DEXA) and serum osteocalcin level was determined by radioimmunoassay. Analysis of covariance was used to test differences in mean BMDs across genotypes. RESULTS: We realized that VDR genotype frequencies in Chinese women were apparently different from those of Caucasians. In group of postmenopausal women, "bb" or "aa" genotype was related to lower BMD in Femoral Neck and Trochanter. No association was found between VDR genotypes and the serum osteocalcin level. CONCLUSION: There was some association between VDR genotypes and BMD in Chinese women. Its function in predicting osteoporosis still requires further study.
Adult↗
[Study of PEFV curves in 520 normal middle-aged and old humans].
Partial expiratory flow-volume(PEEV) curves and other pulmonary functions were performed for 520 (20-86 yr) normal midde-aged and old humans. The regression equations of V at FRC (VFRC, volume corrected VFRC (VFRC/FVC), flows at various lung volumes (V75, V50, V25) and specific time constants (S tau 75, S tau 50, S tau 25) were built with multiple stepwise regression analysis. VFRC decreased with increase of age, but after correction with FVC, the correlation of VFRC/FVC with age decreased. The regressions were tested with substitution of parameters with normal persons and proved to be correct. This study suggests that PEFV curve with convenient method has theoretical and practical significance.
Adult↗
[Cloning and endonuclease digestion of lon gene from Streptomyces ansochromogenes].
Streptomyces ansochromogenes is a nikkomycin producer which has typical life cycle of Streptomyces differentiation on glucose asparagine medium. The lon gene product is an ATP-dependent serine proteinase. The lon gene might have some connection with physiological differentiation and also with the morphological differentiation in S. coelicolor. The lon-like gene of S. ansochromogenes was identified by hybridization and the lon-like gene in 4.6 kb PstI fragment was cloned. The physical map of this fragment and the localization of the target gene were preliminarily studied.
Cloning, Molecular↗
[Myocardial cells action potential and contractive function in hemorrhagic shock in rabbits].
Anesthetized rabbits were subjected to a moderate degree of hemorrhagic shock. Lowering their mean arterial pressure to 5.3 KPa for 3 h, we measured the mean arterial pressure (MBP), left ventricular systolic pressure (LVSP), left ventricular maximum velocities of contraction (dp/dtmax), and myocardial electrical activity. The results of this study demonstrated that LVSP declined in parallel with MBP; that dp/dtmax dropped acutely on the instant of hemorrhagic shock; dp/dtmax went up by 48% on 15 min after shock; then dp/dtmax fell gradually, and by 3 h after shock the dp/dtmax values dropped to 20% of the baseline values; that intracellular sodium and potassium contents increased significantly in the hemorrhagic shocked rabbits; that myocardial resting potential (RP) and action potential amplitude (APH) diminished; and that action potential duration(APD), action potential repolarized 50% duration (APD 50), and repolarized 90% duration (APD 90) were markedly prolonged in the hemorrhagic shock, compared with control. The results suggested that in hemorrhagic shock myocardial cells fast sodium channel was closed while slow sodium and slow calcium channels, were opened; thus sodium and calcium infused and potassium exuded.
Action Potentials↗
Chinese dietary composition and intakes of elements and radionuclides by ingestion.
As update and complement of Chinese Total Diet Study in 1990, a renewing study was conducted during 1992-1993 according to regulated procedure. Contents of 32 elements, including 19 newly determined, in 12 categories of food from 12 provinces were analyzed by NAA or AAS technique and the daily intakes of Chinese adult man were estimated and hygienically evaluated. Meanwhile, a typical survey on dietary composition and intake for difference among 4 age groups and between Spring and Autumn was surveyed too. The results provide important basis for decision for further improvement of Chinese diet from hygienic view point and compilation of physiological characteristics of Chinese Reference Man. At the end of this article, the estimated nationwide average intakes for adult man are compared with those for current ICRP Reference Man.
Adolescent↗
Percutaneous reduction and stabilization of complex tibial plateau fractures.
Mechanical traction and percutaneous reduction by leverage and fixation by a bilateral groove external fixator were performed on 23 patients with complex tibial plateau fractures involving a depressed and split fragments. The fixator is composed of two long groove frames, three to five nuts, hooked bolts and Steinmanns pins. All fractures united in good position in three months with no incision (only pinpricks), little operative trauma and no significant complications but pintract infection, and the flexion-extension range of knee movement was excellent in all patients, so that this technique is particularly advisable for complex tibial plateau fractures.
External Fixators↗
[Thermoregulation under simulated weightlessness].
The effect of simulated weightlessness on thermoregulation was studied in 5 subjects. The experiment consisted of 3d baseline measurements, 7d head-down bed rest and 2d recovery. Circadian rhythm was assessed by continuous measurements of rectal temperature and skin temperature with 2h intervals. Heat Stress Protein 70 (HSP70) was measured by Western-blot Dot method and the facial surface temperature distribution was measured by HR-2 infrared thermography. The results showed that rectal temperature keeps the wake-sleep variation, but the circadian rhythm changed during bed rest, and the change of rectum temperature rhythm appeared mainly in the early-days of bed rest; HSP70 and facial surface temperature increased during bed rest.
Bed Rest↗