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Biomedical subjects

G Lin

Publications and source records attributed to G Lin.

At least 199 records · Page 11Linked to original sources
PubMed1984

Postmortem examination of the blood supply and vascular pattern of small liver metastases in man.

Thirteen human cadavers with liver metastases were examined. Microfil was injected into the portal vein and hepatic artery. The liver metastases were examined under dissecting microscope, and their vascular supply and patterns were registered. It was found that most metastases had both arterial and portal supply even if the arterial supply dominated. Extensive filling of tumor vessels was observed in both lobes in one liver in which the portal vein of one lobe and the hepatic artery of the other was injected (i.e., the same kind of metastases could be filled from either the hepatic artery or the portal vein). It is suggested that the findings could be of great importance in planning treatment of patients with liver metastases.

Adult↗
PubMed1983

Partial ablation of the kidney by intraarterial ethanol in domestic swine.

Partial renal ablation was produced in 15/17 swine kidneys after segmental intraarterial injection of 1-2 ml of 95% ethanol. Complications were seen in 3 kidneys, including reflux of ethanol into nontarget vessels with subsequent total infarction of 2 kidneys, and the development of hydronephrosis in 1 kidney. Strictly selective catheterization and a very slow injection of ethanol are essential to avoid complications. This technique may find clinical application and the possible indications are discussed.

Animals↗
PubMed1983

Experimental evaluation of a new instrument for transcatheter electrocoagulation.

A new coaxial electrode catheter design has been tested in 19 renal arteries of pigs with excellent results, i.e. 100 per cent thrombosis. One vessel ruptured. The electrode (anode) is situated on a thin inner catheter and after electrolysis it is pulled back into a shielding outer catheter. This should reduce downstream embolization. Usual currents have been 8 to 10 mA at 10 V and doses of 16 to 36 C have been used depending on the size of the artery. In the single case of rupture of the vessel a current of 20 mA was used. The method appears to be ready for clinical testing.

Animals↗
PubMed1983

Lateral displacement of the right kidney by the ascending colon.

A case of lateral displacement of the lower pole of the right kidney caused by an interposing ascending colon is presented. An interposition of this kind is rare and does not cause any gastrointestinal symptoms but is of differential diagnostic importance. In this case computed tomography was a simple noninvasive procedure for correct diagnosis.

Aged↗
PubMed1981

In vitro chemotherapeutic testing of urologic tumors.

We studied 20 transitional cell tumors of the bladder and 25 adenocarcinomas of the kidney in vitro to determine their chemotherapeutic sensitivity. The different sensitivity patterns among the individual tumors were demonstrated. Identical drug sensitivity patterns could be identified in the primary and metastatic sites, and in tumor tissue removed from the primary and metastatic deposits in the same patient. Human renal adenocarcinoma maintained in the athymic mouse demonstrated identical chemotherapeutic sensitivity patterns in vitro and in vivo. Our data would support that these in vitro chemotherapy studies may assist in the selection of agents to use in human tumor-bearing hosts.

Adenocarcinoma↗
PubMed1978

Studies on adrenocorticotropic hormone receptor using isolated rat adrenocortical cells.

To clarify the function of ACTH receptors, the actions of ACTH on cyclic AMP formation, Ca2+-influx across cell membrane, and corticoidogenesis were examined using dispersed adrenocortical cells prepared from the rat adrenal gland. 1) There are two types of ACTH receptors from Scatchard analysis of 125I-ACTH1-24 binding to the cell, the one receptor is of high affinity and low capacity (dissociation constant (Kd1) = 2.6 x 10(-19) M and 7,350 sites per cell), and the other one is of low affinity and high capacity (dissociation constant (Kd2) = 7.1 x 10(-9)M and 57,400 sites per cell). 2) Both apparent dissociation constants derived from the effects of ACTH on corticoidogenesis and Ca2+ influx well correspond with Kd1 of the high affinity receptor, 3) Apparent dissociation constant obtained from the effect of ACTH on cyclic AMP formation is in good agreement with Kd2 of the low affinity receptor. Thus it could be deduced from these data that the high affinity receptor is concerned with an increased Ca2+-influx to regulate corticoidogenesis at physiological levels of ACTH, whereas the low affinity receptor is coupled to adenylate cyclase at supraphysiological concentrations of ACTH.

Adrenal Cortex↗
PubMed1976

The effect of ethanol ingestion on the aldehyde dehydrogenases of rat liver.

The effect of ethanol ingestion on aldehyde dehydrogenase activity in the subcellular fractions of livers from 14 pair-fed male Sprague-Dawley rats was tested. Enzymatic assays were performed at two different concentrations of propionaldehyde (0.068 and 13.6 mM) sufficient to saturate enzymes with high and low affinities for propionaldehyde, respectively. The effect of alcohol ingestion varied depending on the subcellular fraction tested and the propionaldehyde concentration used in the assay. There was a 60% increase in the activity of aldehyde dehydrogenase with high affinity for propionaldehyde in the mitochondrial membranes. Conversely there was a 50% decrease in the activity of aldehyde dehydrogenases with high affinity for propionaldehyde in the microsomal fraction. There was also a 58% decrease in the activity of enzymes from the mitochondrial matrix with low affinity for propionaldehyde. The results suggest that differences in the assay systems employed may account for the conflicting results obtained by previous investigators of the effect of ethanol feeding.

Aldehyde Oxidoreductases↗