[Scintigraphy with thallium-201 in the evaluation of vasoactive treatment in subjects with obliterative arteriopathies of the lower limbs].
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Biomedical subjects
Publications and source records attributed to G Licata.
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The antihypertensive effects and haemodynamic changes after administration of 30 mg/die of muzolimine for 30 days in a group of patients with mild or moderate essential hypertension have been evaluated. Our findings showed a significant reduction of body weight, arterial blood pressure, systemic vascular resistance, plasma volume and small but significant increase of left ventricular ejection fraction. No relevant side effect have been observed.
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The authors studied total and free circulating thyroid hormones, rT3, TBG and TSH behaviour on chronic liver disease in 11 subjects with cirrhosis of the liver with ascites(C.E.) and in 6 subjects with chronic active hepatitis (E.C.A.) in comparison with 15 healthy and euthyroid controls. Serum T3,FT3,T4 and FT4 levels were decreased significantly and serum rT3 values increased significantly both in the subjects with C.E. and in patients with E.C.A. Moreover no significantly changes of TSH and TBG levels has been found in 3 groups studied. These data suggest that the alteration of circulating thyroid hormones in chronic liver disease, may represent a compensatory way of reducing the patient's metabolic requirements.
In order to know thyroid function during physical activity, just studied by several authors without univocal findings, we have submitted 10 young subjects, non athletes, aged 22-25 years (mean age 23, 6 +/- 1, 43) to a biologically maximal exercise on a bicycle ergometer. We have also examined the change of TSH serum levels during exercise. Our data show an evident increase of T4 (18, 60% at 10'), p less than 0.025, an increment of FT4 (28, 49 soon after the strain), and no relevant change of T3 and rT3 serum levels. Moreover TSH values show a reduction at 30' (-26, 15%) in comparison with the basal level. Our findings confirm the known increment of T4 and FT4 serum level after physical activity. It can be due, more than an hemoconcentration supported by others, to a real rise of thyroid incretion as in our opinion TSH levels reduction suggests. Concluding we think that the increase of T4 and decrease of TSH could be due to a direct influence of the physical activity on the system interested in their production.
After a rapid review of the reciprocal effects of hGH and testosterone in somatic development during puberty, the behaviour of the growth hormone after appropriate stimulation was examined in prepuberal subjects with underdeveloped gonads. These subjects revealed defective secretion of the hormone which may be explained by a reduction in the efficiency of the diencephalohypophyseal factors controlling puberty and sexual function.
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In 45 type 2 diabetics it was unable to be found a relation between the plasma lipids and the fasting blood glucose (G), HbA1c, reverse T3 (rT3), rT3/T3 ratio, and relative body weight (R.B.W.). The conclusion was reached that the alteration of the lipoprotein metabolism and the thyroid hormones in type 2 diabetics could be primitive and independent from the availability of the insulin.
In 21 type 1 diabetics a significative positive correlation was found between plasma triglycerides (TG) and fasting blood glucose (G), HbA1c, reverse T3 (rT3), rT3/T3 ratio and relative body weight (R.B.W.); total cholesterol (C) and HDL-cholesterol (HDL-C) were not correlated. If you consider the R.B.W. during the correlation between TG and the other laboratory tests, the only correlation that remains significant is that between TG and HbA1c. Plasma hyperTG found in type 1 diabetics appears to depend upon poor diabetic control and overweight; HDL-C is within normal limits because the removal of TG was slightly involved.
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