Search PubMed⌕ Search

Biomedical subjects

G Levin

Publications and source records attributed to G Levin.

79 records · Page 5Linked to original sources
PubMedDate not supplied

Sympathetic adrenomedullary activity in cluster headache.

It is well known that autonomic phenomena, such as lacrimation, rhinorrhea, and Horner's syndrome, are associated with the pain attacks in episodic cluster headache. In order to elucidate the cause of these symptoms we studied plasma free and sulphoconjugated catecholamines in cluster headache patients during the pain attacks and in the following hours, as well as during the remission period. No change in these amine levels was found. We conclude that dysautonomic symptoms are not reflected in plasma catecholamine modification.

Adrenal Medulla↗
PubMedDate not supplied

Lack of response of proenkephalin A and sympathetic nervous system in chronic pain associated with lung cancer.

Since the discovery of the link between peripheral endogenous opioid peptides and pain regulation, these substances have been studied in relation to certain pain conditions. In order to elucidate the effect of chronic pain on both peripheral opioid system and sympathetic nervous activity, we assayed plasma met-enkephalin (ME), neutrophil met-enkephalin containing peptides (NMECP) and plasma free and conjugated catecholamines (CA) in lung cancer patients with chronic pain related to bone metastases and without pain. No significant difference was found in ME levels when the pain cancer group (0.36 +/- 0.06 pmol/ml) was compared to the pain-free group (0.37 +/- 0.04 pmol/ml); results were similar for NMECP levels (14.1 +/- 1.66 pmol/mg prot and 18.41 +/- 1.93 pmol/mg prot, respectively). CA levels in both groups were also similar. These results differ from those we have reported previously for acute pain, suggesting that a non-permanent painful stimulus may be necessary for peripheral opioid system stimulation.

Aged↗
PubMedDate not supplied

Plasma met-enkephalin and catecholamine changes during the menstrual cycle and pain episode in menstrual migraine.

In order to explore opioid, sympathetic and hormonal parameters, we evaluated plasma met-enkephalin (ME), catecholamines (CA), estradiol (E2) and progesterone (P) in different phases of the menstrual cycle and during menstrual crisis in women suffering from menstrual migraine (MM) and in controls. No differences in P and E2 were found between controls and patients. We observed an increase in plasma ME and a decrease in plasma free norepinephrine (NE) levels on day 22 in MM group and an increase in plasma ME, free NE and total epinephrine (E) during pain. Our data, although obtained in a small number of patients, show clear modifications in plasma ME and in the sympathoadrenal function, not only during pain but also in the mid luteal phase.

Adult↗