[Influence of sex hormones on the response intensity of the adrenal-hypothalamo-hypophyseal system to an emotional agression in rats].
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Biomedical subjects
Publications and source records attributed to G Lescoat.
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Brain, hypothalamic and pituitary monoamines were measured in 90-day-old male rats after postnatal exposition to electromagnetic microwaves. The treatment decreased brain serotonin, increased brain 5-hydroxyindoleacetic acid and hypothalamo-pituitary catecholamines. The modifications observed in the levels of the monoamines were correlated with the variation of the gonadotrophin secretion described in a previous work. The mechanism by which microwaves could modify brain and hypothalamo-pituitary monoamines is discussed.
Pituitary gonadotropins and prolactin were measured from day 1 (G1) to day 4 (G4) of gestation in control or chlorpromazine injected rats (Img/100 g body weight every 8 hours during 72 hours). Chlorpromazine induced a modification of pituitary gonadotropins and prolactin (decrease in LH from G1 to G4; decrease in FSH from G1 to G3; increase in PRL from G1 to G4). Differed implantation by chlorpromazine seemed to be due to a decrease in pituitary gonadotropins and an increase in pituitary prolactin.
Plasma corticosterone, gonadotropins and prolactin are measured from day 1 (G1) to day 4 (G4) of gestation in normal or chlorpromazine injected rats. Chlorpromazine induces a modification of plasma corticosterone, gonadotropins and prolactin (increase in corticosterone and prolactin at G1, p less than 0,001 or P less than 0,01; decrease in LH at G2, p less than 0,01; no modification of FSH). Differed implantations by chlorpromazine seems to be due to an increase in plasma corticosterone and prolactin at G1 and a decrease in plasma LH at G2.
1. The authors studied, in adult male and female rats the effect of one or repeated injections of chlorpromazine on adrenal secretion of corticosterone and pituitary secretion of prolactin. 2. Injections of chlorpromazine increased plasma corticosterone, plasma and pituitary prolactin. 3. The discussion of the results was correlated to the brain catecholamines postulated to be neurotransmitters involved in the control of corticotropin and prolactin pituitary secretion.