Biomedical subjects
Publications and source records attributed to G Leonardi.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
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A brief review of the old and new proposed antirabies vaccines was treated. A better immunogenicity, safety and acceptability of the vaccines obtained from nonneural tissues was demonstrated. Some considerations about the human rabies pathogenesis and immunity were also briefly discussed.
After having submitted for review the legislation on the subject of vaccinations in infancy in Common Market Countries, the Author notes that the divergiences revealed on the matter, and others that may still possibly be revealed by a more profound valuation of the various standards, justify the conclusion that harmonization of the various arrangements is not only desirable but necessary. The Author adds that, as far as compulsory vaccinations is concerned, it is possible to find a way to overcome the situation by intensifying and extending in a more detailed manner the work of health education since, in the present social context, a sound vaccination policy ought to be based more on public collaboration than on coercive interference. In awaiting the issue of a community regulation the Author concludes proposing the adoption of an individual health card and vaccination calendar for persons within the Community.
It is compared the true cholinesterase inhibition exerced in vitro either by the tetanus toxin and by "parathion". Rabbit's brain homogenates are used as source of the ChE. 4000 MLD of tetanus toxin show the same inhibitory effect than mg 1 of "parathion", during 30 min of incubation at 37 degrees C.
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In rabbits injected i.m. with 1 MLD of tetanus toxin, the levels of the serum cholinesterase and of the erythrocytic cholinesterase were determined twice every day, during the course of the intoxication, until the death of the animals. The levels of the serum cholinesterase were decreasing day by day, while these of the erythrocytic cholinesterase did not show any significant variation. These results are strictly comparable to those one may observe in organophosphorus poisoning.
As tetanus toxin results inactivated when mixed with mammals brain homogenate (Wassermann-Takaki phenomenon), the same may be observed for the organophosphorus compounds. When the brain homogenates are mixed before with one of both poisons and subsequently, after incubation, with the other, this one keeps its typical toxic activity. This behavior seems to be interpreted as the result from the linkage between the true cholinesterase and one toxic (Wassermann-Takaki phenomenon both for the tetanus toxin and the "parathion"), with the following interference for the second toxic, when added, at the enzymatic level, so that the second toxic remains free.