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Biomedical subjects

G Lemperle

Publications and source records attributed to G Lemperle.

At least 37 records · Page 2Linked to original sources
PubMed1992

Efficacy, tolerability and pharmacokinetics of teicoplanin in patients undergoing breast surgery.

In a prospective open trial, 21 female patients undergoing breast surgery received a single intravenous bolus injection of teicoplanin, 400 mg, 30 minutes before the operation. During surgery, (1 hour after teicoplanin administration), samples of breast and fat tissue and serum were collected; 24 hours and 48 hours after dosing, samples of wound exudate were taken. Teicoplanin concentrations were determined using the RASA method. Teicoplanin levels were lowest in fat tissue. Teicoplanin levels in wound exudate were found to be satisfactorily high. However, teicoplanin levels in fat and breast tissue and in wound exudate exceeded the MIC90 for various staphylococcus strains, such as S. aureus and S. epidermidis. No local or systemic adverse reactions were observed during the trial. Teicoplanin was well tolerated. Preliminary results from this trial, therefore, indicate that teicoplanin may be a suitable antibiotic for use in the prophylaxis of infection in breast surgery.

Adult↗
PubMed1992

[Progress in the use of tissue expanders for defect closure of the body surface--experimental principles].

The principle of soft tissue expansion has been applied in widespread techniques in the field of plastic and reconstructive surgery since Radovan (1976) presented a method in which silicone expanders were subcutaneously implanted. Many experimental and clinical reports have been published since then, dealing particularly with the histomorphology, vascularization, and pathophysiology of expanded skin as well as with surgical techniques. Our own study intends to identify the effects of tissue expanders on the biomechanical, biochemical, and morphological qualities of expanded skin, and to determine the influence of pharmacological therapy during expansion.

Animals↗
PubMed1992

[Siliconoma and rheumatic symptoms--a familial and a questionable complication of silicone implantation].

Ruptured silicone-gel filled implants after breast augmentation or reconstruction may cause siliconomas. These lesions frequently develop years later and should be surgically excised. Since the use of modern double lumen implants they do not occur anymore. The possibility of a correlation between silicone implants and the incidence of rheumatologic disorders is critically evaluated by case reports from the world literature. Up to now, no statistically significant cumulation of these disorders in women with silicone implants can be observed.

Breast↗
PubMed1991

PMMA microspheres for intradermal implantation: Part I. Animal research.

In search of a biocompatible implant for the correction of small deficiencies within the dermal corium as in wrinkles and acne scars, polymethylmethacrylate (PMMA) microspheres, 10 to 63 microns in diameter, were dispersed in Tween 80 medium and injected intradermally and subdermally into the abdominal skin of rats. Histological examination of specimens for up to 7 months revealed a modest tissue reaction, forming a delicate fibrous capsule around each individual microsphere within 4 months. Foreign body giant cells were seen rarely (in up to 1.5% of all cells). No break-down, corrosion, or phagocytosis of the spheres was observed at 7 months. The Tween 80 dispersion medium did not produce any histologically detectable reaction. Because PMMA products (Paladon, Palacos) have been used in medicine for almost 50 years without causing biological degradation or cancer, the material may be applied safely in the form of microspheres (Arteplast) in corium and subcutis of human patients with wrinkles or acne scars.

Animals↗
PubMed1991

[Surgical treatment of male baldness using Juri's crescent flap].

This is a report on thirty six patients with male pattern baldness, surgically treated with one or two parieto-occipital flaps according to Juri. In six patients with isolated occipital baldness, specially designed flaps were used. Since male baldness usually is genetically determined and hairroots of the temporo-occipital scalp remain active throughout life, one can expect that they continue growing within the transposed flaps. There are three indications for parieto-occipital flaps: 1. psychological burden of the patient, 2. genetic background in the family of young patients, and 3. prior punch hair grafts whose roots have atrophied.

Adult↗
PubMed1989

[Sonographic findings in silicone-induced granulomas and lymphadenopathy following mammaplastic surgery].

Ultrasound examination of the breast and its lymphatic drainage was undertaken in 78 patients who--after mammoplasty with silicone implants--had palpable lymph nodes, pain and sensation of tension in the area surrounding the implant. Five patients had space-occupying echo-dense inner structures and dense echos from structures dorsal to the space-occupying ones. In this way silicone granuloma could be demonstrated even preoperatively in tissues, musculature or lymph nodes, although the changes were palpable in only two of the five patients. Ultrasonography can thus be of great importance not only in the diagnosis but also in the preoperative localization of silicone-induced granulomas.

Adult↗
PubMed1989

[Primary excision of third degree burns].

Fresh third-degree burns with a diameter up to that of a hand should be excised primarily and the wound edges closed under tension. Fasciocutaneous flaps can be designed for wound closure especially on the extremitites. This treatment requires half the time of skin grafting. Since patients with huge burn areas often react with hypertrophic scarring for years, a simple reduction of the areas by wide excision and closure under tension appears to be the method of first choice. In contrast to scar tissue healthy skin has a natural ability to stretch when wound margins are closed under maximal tension. The efficacy of possibilities is proven by the many favourable results.

Burns↗
PubMed1989

[Serial excision of large surface burn scars].

Serial excisions of large defined burn scars often improve the aesthetic appearance as well as reduce subjective complaints such as itching and sensory disturbance. The natural elasticity of undamaged skin allows stepwise excision of areas up to the size of a hand. Ideally, a linear scar the length of the original scar area results. Shrinkage, contour and pigment deficiencies, often seen after skin grafting, are not a problem.

Burns↗
PubMed1989

[Plastic correction of thoracic wall burns with reference to the female breast].

Neck and shoulder contractures, large scars of the thoracic wall and breast defects require plastic surgery. If possible, local flaps are the best solution for contractures, eventually enlarged by skin expanders. Full thickness skin grafts, Z-plasties and simple excisions with primary wound closure are alternative methods. For breast reconstruction early skin grafts or secondary local flaps are used. Myocutaneous flaps from the latissimus dorsi or rectus abdominis are seldom indicated.

Burns↗
PubMed1988

[Plastic surgery reconstruction following irradiation].

Radiation damage after combined tumor therapy may involve skin, subcutaneous tissue, nerves, bones and viscera. Ulceration and subsequent infection can result in life-threatening conditions. Early reconstructive procedures restore function, prevent further damage and alleviate pain. Plastic surgery has developed special fasciocutaneous and musculocutaneous flaps for each region.

Extremities↗
PubMed1987

[Primary management of fresh bite injuries of the face].

The danger of dog bites is often exaggerated. The reason for this is a gram negative bacterium Pasteurella multocida, which causes a serious infection within 12 h. Among 143 dog bites we saw only two of these infections. The bacterial swabs from the mouths of 20 dogs revealed E. coli in 43%, Streptococci in 33%, Proteus in 30%, Staph. epidermidis in 27% and Enterococci in 25%. Since the blood supply of the face is much more superior to that for instance of the legs, infections are rare and primary closure of wounds of dog and human bites is recommended. Additional drainage, hospitalisation and local and systemic antibiotics are possible. Open wound therapy in the face can be called obsolete.

Animals↗
PubMed1987

[Surgical therapeutic possibilities in extensive chest wall and rib metastases].

87 extensive tumors of the chest wall were resected in an 8 year period. The defects including subtotal sternectomies and segment resections up to 7 ribs were reconstructed with musculocutaneous flaps without any osteoplasty or implants. The latissimus dorsi flap closes pleural defects safely. The innervated muscle stabilizes the chest wall. The rectus abdominis flap fits defects of greater volume but the blood supply is less reliable. The use of pectoralis major or free microsurgical tissue transfer may be indicated in absence of any other possibility.

Bone Neoplasms↗
PubMed1987

[Retrograde or orthograde anatomic perfusion of the free forearm flap?].

The free forearm flap is ideal for vascularized tissue transfer because of its large vessels and multiple nerve supply. In the case presented a distally based forearm flap on a long vascular pedicle was employed relying on a reversed blood flow. Unfortunately the reversed venous flow did not develop and therefore in order to provide a venous drainage an autologous vein graft was used.

Adult↗
PubMed1987

[Buruli ulcer--necrotizing infection of the hand of a plastic surgeon].

The Buruli ulcer is caused by mycobacterium ulcerans. The clinical features of this atypical mycobacteriosis are similar to tuberculosis. Differentiation is only possible by microbiological investigation. In cases of chronic soft tissue infections mycobacteriosis must be taken into consideration. Since microbiological differentiation needs 8-12 weeks and chemotherapy is not effective, early and wide surgical excision is the treatment of choice.

Hand Dermatoses↗